Effect of Elevated Intra-Abdominal Pressure and Hyperoxia on Portal Vein Blood Flow, Hepatocyte Proliferation and Apoptosis in a Rat Model

Bitterman, Haim; Hayari, Lili; Brod, Vera; Coran, Arnold G.; Shaoul, Ron; Lurie, M.; Eldar, Samuel; Sukhotnik, Igor

doi:10.1055/s-2008-1038920

Cited by 18 publications

(15 citation statements)

References 19 publications

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“…In line with this, according to some authors [36], IAH leads to visceral apoptosis. In combination with hypovolemia, however, it increased lung and liver apoptosis.…”

Section: Impact Of Hypovolemia On the Liver Kidneys And Lungssupporting

confidence: 59%

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Early impact of abdominal compartment syndrome on liver, kidney and lung damage in a rodent model

Lima¹,

Silva²,

Capelozzi³

et al. 2017

Anaesthesiol Intensive Ther

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Background: Abdominal compartment syndrome (ACS) sometimes occurs in critically ill patients following damage control surgery. The purpose of the present study was to develop a model of ACS and to evaluate its pathologic impact on liver, kidney, and lung morphology. Methods: Twenty Wistar rats (mass 300-350 g) were randomly divided into four groups: 1) intra-abdominal hypertension (IAH): a laparotomy was performed and the abdomen packed with cotton until an intra-abdominal pressure (IAP) of 15 mm Hg was reached; 2) hypovolemia (HYPO): blood was withdrawn until a mean arterial pressure ~60 mm Hg was reached; 3) IAH + HYPO (to resemble clinical ACS); and 4) sham surgery. After 3 hours of protective mechanical ventilation, the animals were euthanized and the liver, kidney and lungs removed to examine the degree of tissue damage. Results: IAH resulted in the following: oedema and neutrophil infiltration in the kidney; necrosis, congestion, and microsteatosis in the liver; and alveolar collapse, haemorrhage, interstitial oedema, and neutrophil infiltration in the lungs. Furthermore, IAH was associated with greater cell apoptosis in the kidney, liver and lungs compared to sham surgery. HYPO led to oedema and neutrophil infiltration in the kidney. The combination of IAH and HYPO resulted in all the aforementioned changes in lung, kidney and liver tissue, as well as exacerbation of the inflammatory process in the kidney and liver and kidney cell necrosis and apoptosis. Conclusions: Intra-abdominal hypertension by itself is associated with kidney, liver and lung damage; when combined with hypovolemia, it leads to further impairment and organ damage.

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“…In line with this, according to some authors [36], IAH leads to visceral apoptosis. In combination with hypovolemia, however, it increased lung and liver apoptosis.…”

Section: Impact Of Hypovolemia On the Liver Kidneys And Lungssupporting

confidence: 59%

“…Conversely, Mogilner et al [36] found only mild liver histological alterations with an IAP of 60 mm Hg for 2 hours. These differences may be attributed to the timing of analysis (2 vs. 3 hours), as well as the method used to induce IAH (CO 2 insufflation vs. abdominal packing).…”

Section: Impact Of Hypovolemia On the Liver Kidneys And Lungsmentioning

confidence: 93%

Early impact of abdominal compartment syndrome on liver, kidney and lung damage in a rodent model

Lima¹,

Silva²,

Capelozzi³

et al. 2017

Anaesthesiol Intensive Ther

View full text Add to dashboard Cite

show abstract

“…Such an effect is most pronounced in the liver due to its size. Animal studies have shown that even with intraabdominal pressure of only 10 mmHg, portal venous blood flow is reduced considerably, and that at 20 mmHg, the portal venous flow and hepatic arterial flow are reduced by 35 and 55%, respectively [43]. a b Fig.…”

Section: (Recommendation 1b)mentioning

confidence: 99%

Acute Mesenteric Ischemia

Bala¹,

Kashuk²

2016

Acute Care Surgery Handbook

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“…Specifically, the presence of IAH is known to reduce the blood flow in both the hepatic artery (HA) and the portal vein (PV), thus compromising the liver's physiological capacity to regulate its blood flow (9,18). Furthermore, along with these hemodynamic alterations, IAH has also been shown to result in varying degrees of hepatocyte necrosis, as well as impaired hepatic energy metabolism (19)(20)(21). Interestingly, however, the effects of progressively worsening IAH on liver hemodynamics and the hepatic parenchyma have not been well studied.…”

Section: Abstract Background: While Reduction Of Portal Venous (Pv) mentioning

confidence: 99%

Effect of Increased Intra-abdominal Pressure on Liver Histology and Hemodynamics: An Experimental Study

Antoniou

Kairi

Margonis

et al. 2018

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Effect of Elevated Intra-Abdominal Pressure and Hyperoxia on Portal Vein Blood Flow, Hepatocyte Proliferation and Apoptosis in a Rat Model

Cited by 18 publications

References 19 publications

Early impact of abdominal compartment syndrome on liver, kidney and lung damage in a rodent model

Early impact of abdominal compartment syndrome on liver, kidney and lung damage in a rodent model

Acute Mesenteric Ischemia

Effect of Increased Intra-abdominal Pressure on Liver Histology and Hemodynamics: An Experimental Study

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