Effect of emergency contraception with levonorgestrel or mifepristone on ovarian function

Marions, Lena; Cekan, S.Z.; Bygdeman, M.; Gemzell‐Danielsson, Kristina

doi:10.1016/j.contraception.2003.11.018

Cited by 89 publications

(66 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The mechanisms of LNG include actions affecting follicular development, ovulation, corpus luteum formation, sperm motility, fertilization, blastocyst implantation and endometrial function [7,20,22]. The activity of the substance varies with species, the dose given and the route of administration.…”

Section: Introductionmentioning

confidence: 99%

Effects of Levonorgestrel on Reproductive Hormone Levels and Their Receptor Expression in Mongolian Gerbils (Meriones unguiculatus)

Shi

2011

Exp. Anim.

View full text Add to dashboard Cite

Abstract:The effects of levonorgestrel (LNG) on serum levels of reproductive hormones and their receptor mRNA expression in the ovary and uterus of Mongolian gerbils were examined. The results show that serum follicle-stimulating hormone (FSH) and luteinizing hormone (LH) increased, whereas serum estradiol (E2) and progesterone (P4) decreased profoundly after LNG treatment. LNG down-regulated the mRNA expression of folliclestimulating hormone receptor (FSHR), luteinizing hormone receptor (LHR), estrogen receptor (ER) β and progesterone receptor (PR) in the ovary, and ERα and PR in the uterus of Mongolian gerbils. The down-regulated effects were time-dependent and dose-dependent. LNG had no obvious effects on ERα mRNA expression in the ovary. The findings suggest that LNG impairs reproductive hormone receptor expression at the molecular level in Mongolian gerbils. Also, the two ER subtypes may play different roles in the ovary, and ERβ may not be the predominant ER subtype in the uterus of Mongolian gerbils. The ovary and uterus may be the important sites of action of LNG through its direct progesterone-like effects in Mongolian gerbils.

show abstract

Section: Introductionmentioning

confidence: 99%

Effects of Levonorgestrel on Reproductive Hormone Levels and Their Receptor Expression in Mongolian Gerbils (Meriones unguiculatus)

Shi

2011

Exp. Anim.

View full text Add to dashboard Cite

show abstract

“…De estos 22 artículos, publicados entre 1995 y el 2010, diez estuvieron diseñados para medir el efecto sobre la ovulación (8)(9)(10)(11)(12)(13)(14)(15)(16)(17) , doce el efecto sobre el endometrio (9,12,13,(18)(19)(20)(21)(22)(23)(24)(25)(26) y tres el efecto sobre los espermatozoides (27)(28)(29) . De estos estudios, nueve correspondían a ensayos clínicos (8,9,14,15,18,19,23,24,27) , ocho a estudios cuasi-experimentales (10)(11)(12)(13)16,25,26,29) , tres a estudios observacionales (17,22,28) y dos a estudios in vitro (20,21) .…”

Section: Artículos Seleccionados Para El Análisisunclassified

“…De estos estudios, nueve correspondían a ensayos clínicos (8,9,14,15,18,19,23,24,27) , ocho a estudios cuasi-experimentales (10)(11)(12)(13)16,25,26,29) , tres a estudios observacionales (17,22,28) y dos a estudios in vitro (20,21) . Tres estudios fueron hechos en animales (los tres correspondientes a diseños cuasiexperimentales (13,16,25) ) y el resto en humanos.…”

Section: Artículos Seleccionados Para El Análisisunclassified

“…Cuando es administrado antes de la ovulación logra reducir la probabilidad de embarazos (14) . Su mecanismo de acción esta relacionado con la reducción de los niveles séricos de LH y fSH antes de la ovulación causando una ausencia de ovulación o su postergación (9)(10)(11)(12)15,17) . La efectividad en evitar la ruptura folicular también esta relacionada con el tamaño del folículo (8) .…”

Section: Efectos Sobre La Ovulaciónunclassified

See 1 more Smart Citation

Efecto del levonorgestrel como anticonceptivo oral de emergencia en la ovulación, el endometrio y los espermatozoides

Suárez¹,

Zavala²,

Ureta³

et al. 2010

Rev Peru Med Exp Salud Publica

View full text Add to dashboard Cite

RESUMENExiste amplia controversia acerca del mecanismo de acción del levonorgestrel como anticonceptivo oral de emergencia; numerosas organizaciones, tanto científicas como de la sociedad civil, muestran su disconformidad con su uso, debido a su posible acción como inductor de aborto. Con el objetivo de evaluar la evidencia científica disponible sobre los mecanismos de acción del levonorgestrel utilizado como anticonceptivo oral de emergencia (AOE), se realizó una revisión sistemática en las bases de datos Medline y Cochrane Library donde se encontró 444 artículos; después de revisar los resúmenes, se seleccionó 22 artículos, los cuales fueron evaluados a texto completo. Se encontró que el principal mecanismo de acción del levonorgestrel, a las dosis recomendadas como AOE, es la inhibición o retraso de la ovulación; no afecta a los espermatozoides en su capacidad de migración ni de penetración al óvulo. No se ha demostrado alteraciones morfológicas ni moleculares en el endometrio que puedan interferir con la implantación del huevo fecundado. No existe evidencia científica actual disponible que sustente que el uso de levonorgestrel como AOE sea abortivo.Palabras clave: Anticoncepción postcoital; Levonorgestrel; Endometrio; Ovulación; Espermatozoides (fuente: DeCS BIREME). EFFECT OF LEVONORGESTREL IN THE OVULATION, ENDOMETRIUM, AND SPERMATOZOA FOR EMERGENCY ORAL CONTRACEPTION ABSTRACTThere is wide controversy about the mechanism of action of the levonorgestrel used for emergency oral contraception, and many organizations, both scientific as well as from the civil society, show their discrepancy with its use, due to its possible action as an abortion-inducer. In order to evaluate the scientific evidence available on the mechanisms of action of the levonorgestrel used for emergency oral contraception (EOC), a systematic revision was performed in the Medline and Cochrane library databases. We found 444 articles. After reviewing the abstracts, we selected 22 articles, whose complete texts were evaluated. We found that the main mechanism of action of the levonorgestrel, given at the doses recommended for EOC, is the inhibition or retardation of the ovulation, it doesn't affect the spermatozoa in their migration or egg-penetration capacities. No morphological or molecular alterations in the endometrium that could interfere with the implantation of the fertilized egg have been demonstrated. There is no actual scientific evidence available supporting that the use of levonorgestrel for EOC is abortive.

show abstract

“…9 Mechanism of action of ECP was to inhibit or delay ovulation. [10][11][12] Additional possible mechanisms of action include interference with corpus luteum function; thickening of the cervical mucus resulting in trapping of sperm; alterations in the tubal transport of sperm, egg or embryo and direct inhibition of fertilization. [13][14] There are two common types of hormonal ECPs: First, combined ECPs containing both estrogen and progestin (Yuzpe regimen) and second, progestin-only ECP.…”

Section: Introductionmentioning

confidence: 99%

Knowledge, attitude and practice regarding emergency contraceptive pills among female health workers of a tertiary care hospital in Karachi

Ahmed

Naz

Iqbal

et al. 2016

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

Effect of emergency contraception with levonorgestrel or mifepristone on ovarian function

Cited by 89 publications

References 17 publications

Effects of Levonorgestrel on Reproductive Hormone Levels and Their Receptor Expression in Mongolian Gerbils (Meriones unguiculatus)

Effects of Levonorgestrel on Reproductive Hormone Levels and Their Receptor Expression in Mongolian Gerbils (Meriones unguiculatus)

Efecto del levonorgestrel como anticonceptivo oral de emergencia en la ovulación, el endometrio y los espermatozoides

Knowledge, attitude and practice regarding emergency contraceptive pills among female health workers of a tertiary care hospital in Karachi

Contact Info

Product

Resources

About