Effect of Emergency Department Care Bundle on Elderly Patients With Acute Heart Failure

Liu, Kan

doi:10.1001/jama.2020.27291

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2023

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“…Even in patients with onset of hypertension <40 years, the median duration of hypertension at the time of diagnosis of PA was 10.5 years (3.5-18 years) (Alam et al 2021). It is therefore not surprising that less than 0.1% of 1.1 million Canadian adults with hypertension (Liu 2021) and less than 0.1% of an Australian primary care hypertensive population received a diagnosis of PA (Yang et al 2018).…”

Section: Introductionmentioning

confidence: 99%

Mineralocorticoid receptor signalling in primary aldosteronism

Yang

Young

Cole

et al. 2023

Journal of Endocrinology

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Primary Aldosteronism, or Conn Syndrome, is the most common endocrine cause of hypertension. It is associated with a higher risk of cardiovascular, metabolic and renal diseases, as well as a lower quality of life than for hypertension due to other causes. The multi-systemic effects of primary aldosteronism can be attributed to aldosterone-mediated activation of the mineralocorticoid receptor in a range of tissues. In this review, we explore the signalling pathways of the mineralocorticoid receptor, with a shift from the traditional focus on the regulation of renal sodium-potassium exchange to a broader understanding of its role in the modulation of tissue inflammation, fibrosis and remodelling. The appreciation of primary aldosteronism as a multi-system disease with tissue-specific pathophysiology may lead to more vigilant testing and earlier institution of targeted interventions.

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Section: Introductionmentioning

confidence: 99%