Effect of empiric intravenous intralipid therapy on pregnancy outcome in women with unexplained recurrent implantation failure undergoing intracytoplasmic sperm injection-embryo transfer cycle: a randomized controlled trial

Al-Zebeidi, Jawharah; Agdi, Mohammed; Lary, Sahar; Al-Obaid, Solaiman; Salim, Gamar; Al‐Jaroudi, Dania

doi:10.1080/09513590.2019.1631280

Cited by 27 publications

(37 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We included a total of five trials in our meta-analysis (n = 843 women). 20,21,[24][25][26] Two trials were from Egypt and one was from each of the United Kingdom, India, and Saudi Arabia. All trials used 20% IVI solution at the time of embryo transfer but there were variations in the volume given and the duration of the protocol.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…While all trials used 20% IVI solutions, there were variations in the used doses, frequency of IVI administration, and in the ART protocols which could increase the performance bias. For example, three trials used a diluted form of IVI in normal saline 20,24,25 while the other two used a concentrated form of IVI prior to its use. 23,27 Due to the small number of included studies, we were unable to explore this further using a meta-regression.…”

Section: Strength and Limitationsmentioning

confidence: 99%

See 1 more Smart Citation

Intralipid infusion at time of embryo transfer in women with history of recurrent implantation failure: A systematic review and meta‐analysis

Rimmer

Black

Keay

et al. 2021

J of Obstet and Gynaecol

View full text Add to dashboard Cite

Aim: Recurrent implantation failure (RIF) affects 10% of couples undergoing assisted conception, often due to poor endometrial receptivity. We conducted a systematic review and meta-analysis to evaluate the effectiveness of Intra-venous intralipid (IVI) in improving pregnancy rates in women with history of RIF using. Methods: We searched MEDLINE, EMBASE, and CENTRAL for any randomized trials evaluating the use of IVI at the time of embryo transfer in women undergoing assisted conception until September 2020. We extracted data in duplicate and assessed risk of bias using the Cochrane Risk of Bias tools. We metaanalyzed data using a random effect model. Results: We included five randomized trials reporting on 843 women with an overall moderate risk of bias. All trials used 20% IVI solution at the time of embryo transfer compared to normal saline infusion or no intervention (routine care). The IVI group had a higher chance of clinical pregnancy (172 vs 119, risk ratio [RR] 1.55, 95% confidence interval [CI] 1.16-2.07, I 2 44.2%) and live birth (132 vs 73, RR 1.83, 95% CI 1.42-2.35, I 2 0%) post treatment compared to no intervention. Our findings are limited by the small sample size and the variations in treatment protocols and population characteristics. Conclusion:There is limited evidence to support the use of IVI at the time of embryo transfer in women with the history of RIF. More research is needed before adopting it in clinical practice.

show abstract

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Section: Strength and Limitationsmentioning

confidence: 99%

Intralipid infusion at time of embryo transfer in women with history of recurrent implantation failure: A systematic review and meta‐analysis

Rimmer

Black

Keay

et al. 2021

J of Obstet and Gynaecol

View full text Add to dashboard Cite

show abstract

“…After a full review, we excluded 19 systematic reviews or meta-analysis 2,5,22,23,37,[46][47][48][49][50][51][52][53][54][55][56][57][58][59] , 8 case reports [60][61][62][63][64][65][66][67] , 4 letters to the editor [68][69][70][71] and 81 original studies [references and reasons for exclusion are reported in Table 1]. Data on the efficacy of therapies and interventions for RIF were extracted from the remaining 42 articles 8,12,13,18,20,21,24,27,28,31,75, . Included studies investigated uterine interventions, laboratory and procedural technologies and interventions and immunomodulatory therapies.…”

Section: Resultsmentioning

confidence: 99%

Efficacy of therapies and interventions for repeated embryo implantation failure: a systematic review and meta-analysis

Busnelli

Somigliana

Cirillo

et al. 2021

Sci Rep

View full text Add to dashboard Cite

The aim of the present systematic review and meta-analysis was to assess the effect of the different therapeutic options for repeated embryo implantation failure (RIF) on a subsequent IVF cycle outcome. Twenty-two RCTs and nineteen observational studies were included. Pooling of results showed a beneficial effect of intrauterine PBMC infusion on both CPR (RR 2.18; 95% CI 1.58–3.00; p < 0.00001; OR 2.03; 95% CI 1.22–3.36; p = 0.006) and LBR (RR 2.41; 95% CI 1.40–4.16; p = 0.002; OR 3.73; 95% CI 1.13–12.29; p = 0.03), of subcutaneous G-CSF administration on CPR (RR 2.29; 95% CI 1.58–3.31; p < 0.0001) and of intrauterine PRP infusion on CPR (RR 2.45; 95% CI 1.55–3.86; p = 0.0001). Observational studies also demonstrated a positive effect of IVIG and intrauterine hCG infusion on both CPR and LBR and of atosiban on CPR. Studies investigating intrauterine G-CSF infusion, LMWH, intravenous intralipid, hysteroscopy, blastocyst-stage ET, ZIFT, PGT-A and AH failed to observe an impact on IVF outcome. The quality of the evidence that emerged from RCTs focused on intrauterine PBMC infusion and subcutaneous G-CSF administration was moderate. For all other therapies/interventions it varied from low to very low. In conclusion, intrauterine PBMC infusion and subcutaneous G-CSF administration are the most promising therapeutic options for RIF. However, further well conducted RCTs are necessary before their introduction into clinical practice.

show abstract

“…Evidence from both animal 20 and human 3,4,18,21‐23 studies suggests that intralipid administered intravenously may enhance implantation and maintenance of pregnancy. However, not all human studies have shown an improvement in pregnancy outcome after treatment with intralipid 24‐30 . The results of these studies are summarized in Table 1.…”

Section: Success Rates Of Intralipid Therapymentioning

confidence: 99%

“…Chemical pregnancy was recorded for 84 (58.3%) of 144 women in the intralipid group and 76 (50%) of 152 in the control group ( P = .129) 24 . Among the studies that selected patients for treatment based on reproductive history alone, 26‐30 all reported no enhancement after intralipid treatment except one 25 . In one study 21 showing the benefit of treatment with intralipid, 27 of 68 women (40%) with a history of recurrent implantation failure became pregnant after in vitro fertilization and embryo transfer.…”

Section: Success Rates Of Intralipid Therapymentioning

confidence: 99%

Intralipid treatment for women with reproductive failures

Coulam

2020

American J Rep Immunol

View full text Add to dashboard Cite

Does intravenous intralipid treatment for reproductive failure enhance live births? The answer to this question is yes, BUT only in patients that have a diagnosis of recurrent implantation failure (RIF) or recurrent pregnancy loss (RPL) loss AND demonstrate elevated NK (natural killer) cell density in their endometrial biopsy. Live birth rates have been reported between 33% and 42% among women displaying elevated NK activity with a diagnosis of RIF and 75% and 91% among women experiencing RPL after intralipid infusion. When the pregnancy outcomes of women with a history of reproductive failure and elevated NK cells treated with intralipid were evaluated, the overall live birth rate per cycle of treatment was 61%. The results of published studies suggest that intralipid can be used successfully as a therapeutic option to modulate abnormal NK activity in women with reproductive problems.

show abstract

Effect of empiric intravenous intralipid therapy on pregnancy outcome in women with unexplained recurrent implantation failure undergoing intracytoplasmic sperm injection-embryo transfer cycle: a randomized controlled trial

Cited by 27 publications

References 15 publications

Intralipid infusion at time of embryo transfer in women with history of recurrent implantation failure: A systematic review and meta‐analysis

Intralipid infusion at time of embryo transfer in women with history of recurrent implantation failure: A systematic review and meta‐analysis

Efficacy of therapies and interventions for repeated embryo implantation failure: a systematic review and meta-analysis

Intralipid treatment for women with reproductive failures

Contact Info

Product

Resources

About