Effect of end group polarity upon the lower critical solution temperature of poly(2-isopropyl-2-oxazoline)

Huber, Stephan; Hutter, Naima A.; Jordan, Rainer

doi:10.1007/s00396-008-1942-7

Cited by 123 publications

(111 citation statements)

References 55 publications

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“…[51] A distinct difference in the degrees of hydration suggests that longer poly(2-oxazoline) head groups can take up more water than oligo(-ethylene oxide) head groups possessing much fewer conformational degrees of freedom. [10,52] …”

Section: Discussionmentioning

confidence: 98%

Modulation of Substrate–Membrane Interactions by Linear Poly(2‐methyl‐2‐oxazoline) Spacers Revealed by X‐ray Reflectivity and Ellipsometry

et al. 2009

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Hydrated polymer interlayers between planar lipid membranes and solid substrates provide a water reservoir and thus maintain a finite membrane-substrate distance. Linear polymer spacers attached to lipid head groups (lipopolymer tethers) can be used as a defined model of oligo- and polysaccharides covalently anchored on cell surfaces (glycocalyx). They can offer a unique advantage over membranes physisorbed on polymer films (called polymer-cushioned membranes), owing to their ability to control both the length and density of polymer chains. In this study, a lipopolymer tether composed of a stable ether lipid moiety and a hydrophilic poly(2-methyl-2-oxazoline) spacer with a length of 60 monomer units is used to fabricate supported membranes by the successive deposition of proximal (lower) and distal (upper) leaflets. Using specular X-ray reflectivity and ellipsometry, we systematically investigate how the lateral density of polymer chains influences the membrane-substrate interactions. The combination of two types of reflectivity techniques under various conditions enables the calculation of quantitative force-distance relationships. Such artificial membrane systems can be considered as a half-model of cell-cell contacts mediated via the glycocalyx, which reveals the influence of polymer chain density on the interplay of interfacial forces at biological interfaces.

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Section: Discussionmentioning

confidence: 98%

Modulation of Substrate–Membrane Interactions by Linear Poly(2‐methyl‐2‐oxazoline) Spacers Revealed by X‐ray Reflectivity and Ellipsometry

et al. 2009

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“…Yan and co-workers showed a crystalline inclusion complex formation using γ-cyclodextrin, but none with α-or β-cyclodextrin due to a geometric hindrance of the methyl side-groups of pMeOx that, according to molecular modeling, were too voluminous for α-or β-cyclodextrin. In order to fine-tune the LCST of p i PrOx, not only the initiator and/or termination method by various reactants but also the sequential block copolymerization with MeOx was investigated by Jordan et al [40]. Telechelic groups like methyl, n-nonyl, piperidine, piperazine, oligo(ethylene glycol) and oligoMeOx were used.…”

Section: Advanced Organic Initiatorsmentioning

confidence: 99%

Design Strategies for Functionalized Poly(2-oxazoline)s and Derived Materials

2013

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Abstract:The polymer class of poly(2-oxazoline)s currently is under intensive investigation due to the versatile properties that can be tailor-made by the variation and manipulation of the functional groups they bear. In particular their utilization in the biomedic(in)al field is the subject of numerous studies. Given the mechanism of the cationic ring-opening polymerization, a plethora of synthetic strategies exists for the preparation of poly(2-oxazoline)s with dedicated functionality patterns, comprising among others the functionalization by telechelic end-groups, the incorporation of substituted monomers into (co)poly(2-oxazoline)s, and polymeranalogous reactions. This review summarizes the current state-of-the-art of poly(2-oxazoline) preparation and showcases prominent examples of poly(2-oxazoline)-based materials, which are retraced to the desktop-planned synthetic strategy and the variability of their properties for dedicated applications.

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“…[52,57,59] On the other hand, 2-isopropyl-2-oxazoline is slightly less reactive than n-alkyl monomers, consequently forming gradient copolymers. [55,63] A quasi-block copolyoxazoline was obtained from the copolymerization of 2-ethyl-2-oxazoline and 2-phenyl-2-oxazoline under microwave irradiation. [58] This way, by choosing the proper comonomer system, it is possible to design copolymers with adjusted bulk properties (glass transition temperature, surface properties, morphology) [64] or thermo-sensitivity (cloud point).…”

Section: Macromolecular Engineeringmentioning

confidence: 99%

Poly(2‐oxazoline)s as Smart Bioinspired Polymers

Schlaad

Diehl

Greß

et al. 2010

Macromol. Rapid Commun.

288

204

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Poly(2-alkyl-2-oxazoline)s can be regarded as pseudo-peptides or bioinspired polymers, which are available through living/controlled cationic polymerization and polymer ("click") modification procedures. Materials and solution properties may be adjusted via the nature of the side chain (hydrophilic-hydrophobic, chiral, bio-functional, etc.), opening the way to stimulus-responsive materials and complex colloidal structures in aqueous environments. Herein, we give an overview over the macromolecular engineering of polyoxazolines, including the synthesis of biohybrids, and the "smart"/bioinspired aggregation behavior in solution.

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Effect of end group polarity upon the lower critical solution temperature of poly(2-isopropyl-2-oxazoline)

Cited by 123 publications

References 55 publications

Modulation of Substrate–Membrane Interactions by Linear Poly(2‐methyl‐2‐oxazoline) Spacers Revealed by X‐ray Reflectivity and Ellipsometry

Modulation of Substrate–Membrane Interactions by Linear Poly(2‐methyl‐2‐oxazoline) Spacers Revealed by X‐ray Reflectivity and Ellipsometry

Design Strategies for Functionalized Poly(2-oxazoline)s and Derived Materials

Poly(2‐oxazoline)s as Smart Bioinspired Polymers

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