Effect of endocrine disrupting chemicals on the transcription of genes related to the innate immune system in the early developmental stage of zebrafish (Danio rerio)

Jin, Yuanxiang; Chen, Rujia; Liu, Weiping; Fu, Zhengwei

doi:10.1016/j.fsi.2010.02.009

Cited by 172 publications

(80 citation statements)

References 63 publications

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“…Also, arsenic in low doses (10-100 ppb) has been shown to affect expression of genes associated with immune response (Mattingly et al, 2009). Scoring biomarkers of the innate immune system, several endocrine disruptors including 17b-estradiol, 17a-ethynyestradiol, permethrin, atrazine, and nonylphenol have been found to induce immunotoxicity (Jin et al, 2010). Moreover, genes (such as bcl2, ucp2, and iNOS) associated with reactive oxygen species and nitrogen reactive free radical production were also influenced by the endocrine disruptors, suggesting that heavy oxidative stress and the balance of nitric oxide production might cause the death of immune cells (Jin et al, 2010) (Table 11).…”

Section: Developmental Immunotoxicitymentioning

confidence: 99%

Developmental toxicity screening in zebrafish

McCollum

Ducharme

Bondesson

et al. 2011

Birth Defects Research Part C: Embryo Today: Reviews

139

101

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Given the ever-increasing toxic exposure ubiquitously present in our environment as well as emerging evidence that these exposures are hazardous to human health, the current rodent-based regulations are proving inadequate. In the process of overhauling risk assessment methodology, a nonrodent test organism, the zebrafish, is emerging as tractable for medium- and high-throughput assessments, which may help to accelerate the restructuring of standards. Zebrafish have high developmental similarity to mammals in most aspects of embryo development, including early embryonic processes, and on cardiovascular, somite, muscular, skeletal, and neuronal systems. Here, we briefly describe the development of these systems and then chronicle the toxic impacts assessed following chemical exposure. We also compare the available data in zebrafish toxicity assays with two databases containing mammalian toxicity data. Finally, we identify gaps in our collective knowledge that are ripe for future studies.

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Section: Developmental Immunotoxicitymentioning

confidence: 99%

Developmental toxicity screening in zebrafish

McCollum

Ducharme

Bondesson

et al. 2011

Birth Defects Research Part C: Embryo Today: Reviews

139

101

View full text Add to dashboard Cite

show abstract

“…One of the ill effects of insecticides' arrival into surface waters may be an induction of chromosomal damage in eggs and larvae of fishes in different stages of development. Some insecticides that behave as endocrine active compounds can change the expression of vital genes resulting in unusual concentrations of plasma steroid hormones and reproductive dysfunction or immuosuppression (Jin et al, 2010).…”

Section: Genotoxicitymentioning

confidence: 99%

Adverse Effect of Insecticides on Various Aspects of Fish’s Biology and Physiology

Banaee¹

2012

Insecticides - Basic and Other Applications

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“…The previous reports showed that permethrin (PM) was a highly toxic synthetic pyrethroid pesticide widely used in agriculture aquatic organisms and vector control programs (Vadhana et al, 2010;Fojut and Young, 2011;Srivastava et al, 2006). Reproductive toxic (Zhang et al, 2008), immunotoxic (Jin et al, 2010), neurotoxic (De Micco et al, 2010) and cardiotoxic (Vadhana et al, 2010) effects of PM were reported. PM was also shown to induce DNA damage on rat heart cells (Vadhana et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Olive (Olea europaea L.) leaf extract counteracts genotoxicity and oxidative stress of permethrin in human lymphocytes

Türkez

Toğar

2011

J. Toxicol. Sci.

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-The aim of this study was to investigate the protective effects of olive leaf extract (OLE) on genotoxicity and oxidative damage in cultured human blood cells treated with permethrin (PM) in the presence of a rat liver S9 mix containing cytochrome P 450 enzymes. Anti-genotoxic activities of OLE were studied using sister chromatid exchange (SCE) and chromosome aberration (CA) tests and furthermore total antioxidant capacity (TAC) and total oxidative status (TOS) were examined to determine the oxidative damage. Our results clearly revealed that treatment with PM (200 mg/l) alone increased SCE and CA rates and TOS level, decreased TAC level in cultured human blood cells. The OLE alone at the all tested doses did not induce any significant changes in the genotoxicity endpoint. However OLE leads to increases of plasma TAC level in vitro. OLE starts showing this positive effect at 100 mg/l. The combined treatment showed significant improvements in cytogenetic and biochemical parameters tested. Moreover, this improvement was more pronounced in the group received the high dose of the OLE. It could be concluded that the ethanol extract of OLE induced its genoprotective effect via the increase in the antioxidant capacity, inhibition of oxidative stress and scavenging of free radicals.

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Effect of endocrine disrupting chemicals on the transcription of genes related to the innate immune system in the early developmental stage of zebrafish (Danio rerio)

Cited by 172 publications

References 63 publications

Developmental toxicity screening in zebrafish

Developmental toxicity screening in zebrafish

Adverse Effect of Insecticides on Various Aspects of Fish’s Biology and Physiology

Olive (Olea europaea L.) leaf extract counteracts genotoxicity and oxidative stress of permethrin in human lymphocytes

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