2020
DOI: 10.1177/2320206820958239
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Effect of Endodontic Treatment on Serum Glutathione (GSH) Levels in Patients with Chronic Apical Periodontitis: A Clinical Pilot Study

Abstract: Aim: To assess the before- and after-treatment levels of glutathione (GSH) in the serum of patients with chronic apical periodontitis. Materials and Methods: The study involved 20 systemically healthy patients with radiographic evidence of chronic apical periodontitis in at least one tooth, of which 11 were finally assessed. 10 mL of the patient’s venous blood was obtained before commencing the endodontic treatment to assess the pre-operative serum GSH levels (T0). The canals cleaned and shaped, and irrigated … Show more

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“…Research shows that, in addition to periodontitis, oxidative stress in the oral cavity is also associated with other local factors and diseases, such as oral lichen planus, oral 2 of 11 cancer, leukoplakia, recurrent aphthous stomatitis, caries, and periapical lesions [9][10][11][12][13][14][15]. The extant literature further suggests that different treatment protocols, such as nonsurgical periodontal therapy, laser and photoactivation therapy, endodontic treatment, and tooth extraction, impact the value of oxidative stress markers [13,[16][17][18].…”
Section: Introductionmentioning
confidence: 99%
“…Research shows that, in addition to periodontitis, oxidative stress in the oral cavity is also associated with other local factors and diseases, such as oral lichen planus, oral 2 of 11 cancer, leukoplakia, recurrent aphthous stomatitis, caries, and periapical lesions [9][10][11][12][13][14][15]. The extant literature further suggests that different treatment protocols, such as nonsurgical periodontal therapy, laser and photoactivation therapy, endodontic treatment, and tooth extraction, impact the value of oxidative stress markers [13,[16][17][18].…”
Section: Introductionmentioning
confidence: 99%