Effect of endogenous and exogenous hormones on testicular cancer: the epidemiological evidence

Giannandrea, Fabrizio; Paoli, Donatella; Figà–Talamanca, Irene; Lombardo, Francesco; Lenzi, Andrea; Gandini, L.

doi:10.1387/ijdb.130015fg

Cited by 66 publications

(59 citation statements)

References 77 publications

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“…The PubMed search identified 104 articles, of which only two included information on association between baldness and testicular cancer. The references of a review on hormonal exposure and testicular cancer (Giannandrea et al, 2013) and references of the identified papers were scrutinized, but we did not find additional relevant articles.…”

Section: Systematic Reviewmentioning

confidence: 99%

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Baldness and testicular cancer: the EPSAM case–control study

et al. 2016

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SUMMARYThe etiology of testicular cancer is largely unexplained. Research has mainly focused on prenatal exposures, especially to sex hormones, while less attention has been paid to exposures that may act also postnatally. As baldness has been previously associated with testicular cancer risk we focused on baldness and body hairiness, which are both associated with androgen activity. We used data of the Postnatal Exposures and Male Health (EPSAM) study, a case-control study on testicular cancer conducted in the Province of Turin, Italy, involving cases diagnosed between 1997 and 2008. Information was collected using mailed questionnaires. Analyses included 255 cases and 459 controls. We calculated ORs and 95% CIs to estimate testicular cancer risk among those who developed baldness and among those with body hairiness. We found an inverse association between testicular cancer and baldness (OR: 0.67, 95% CI: 0.46-0.98) and body hairiness (OR: 0.78, 95% CI: 0.53-1.16), although the latter had wider CIs. The inverse association between baldness and testicular cancer is consistent with the results from previous studies. These results suggest that androgens activity may influence testicular cancer risk.

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Section: Systematic Reviewmentioning

confidence: 99%

“…As differentiation of germ cells is under hormonal control (Rajpert-De Meyts & Hoei-Hansen, 2007;Sonne et al, 2009), exposures that affect the endocrinological framework during these periods have been deeply studied (Giannandrea et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Baldness and testicular cancer: the EPSAM case–control study

et al. 2016

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“…Indeed, diethylstilboestrol represents the paradigm of transplacental carcinogesis due to xenoestrog-ens. An increased level of endogen estrogen and xenoe-strogens is related with cancers of reproductive system in mammals such as (DES), fat diet (which may be at least partly related to increased exposure to bioaccumulating lipophilic xenoestrogens), dairy products which contain cow's estrogen, and internal body burden polychlorinated biphenyls etc [51]. The transplacental exposure to environ-mentally relevant doses of Bisphenol A may cause persistent alterations in mammary gland morphogenesis in female mice, such as increased terminal end bud density at puberty as well as an increased number and lateral branching of terminal ends in adults, which are the sites at which cancer arises in humans and rodents [52]; effects included enhanced sensitivity to estradiol, decreased apoptosis as well as increased number of progesterone receptor-positive epithelial cells at puberty.…”

Section: Transplacental Exposure To Xenoestrogens and Cancer Riskmentioning

confidence: 99%

“…In utero exposure to xenoestrogens has been implicated as contributing factor in the testicular dysgenesis syndrome, characterized by in utero abnormal and deficient masculini-zation of the male reproductive tract, leading to an increased risk of infertility and testicular germ cell tumours in young adults. Although cryptorchidism and family history of testicular cancer are important risk factors for this disease, transplacental and early life exposure to increased levels of endogenous estrogen or xenoestrogens or antiandrogenic factors [51] surely play a role. Indeed, rather than simply "low androgen", the shift of estradiol-testostorene balance seems pivotal for abnormal male programming [55].…”

Section: Transplacental Exposure To Xenoestrogens and Cancer Riskmentioning

confidence: 99%

Gender and Age Related Modulation of Xenoestrogen-Induced Tumorigenesis

Fučić¹,

Mantovani²

2016

Open Biot. J.

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Susceptibility to environmental stressors, same as cancer incidence is both age and gender related. Understanding the complexity of responses to living environment has been impaired due to research based on reductionisms and lack of methods, models and sophisticated softwares which enable analysis of complex pathways which may be disturbed by xenobotics. Impact of estrogen on development, maturation and homeostasis of organism in both genders is now well recognised and environmental investigations are currently making major efforts to understand how xenoestrogens affect organisms at very low doses. Additionally, it is of great interest to learn possible synergistic or antagonistic effects of xenoestrogen mixtures on adult organism and during development. The aim of this paper is to review the findings on the association between cancer risk and the endocrine disrupters which directly or indirectly mimic estrogen action.

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“…An increased level of endogen estrogen and xenoestrogens is related with cancers of reproductive system in mammals such as diethystilbestrol, fat diet (which may be at least partly related to increased exposure to bioaccumulating lipophilic xenoestrogens), dairy products which contain cow's estrogen, and internal body burden polychlorinated biphenyls etc [51] . The transplacental exposure to environmentally relevant doses of Bisphenol A may cause persistent alterations in mammary gland morphogenesis in female mice, such as increased terminal end bud density at puberty as well as an increased number and lateral branching of terminal ends in adults, which are the sites at which cancer arises in humans and rodents [52]; effects included enhanced sensitivity to estradiol, decreased apoptosis as well as increased number of progesterone receptor-positive epithelial cells at puberty.…”

Section: Transplacental Exposure To Xenoestrogens and Cancer Riskmentioning

confidence: 99%

Gender and Age Related Modulation of Xenoestrogen-Induced Tumorigenesis

Fučić¹,

Mantovani²

2015

TOBIOTJ

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Susceptibility to environmental stressors, same as cancer incidence is both age and gender related. Understanding the complexity of responses to living environment has been impaireddue to research based on reductionisms and lack of methods, models and sophisticated softwares which enable analysis of complex pathways which may be disturbed by xenobotics. Impact of estrogen on development, maturation and homeostasis of organism in both genders is now well recognised and environmental investigations are currently making major efforts to understand how xenoestrogens affect organisms at very low doses.Additionally, it is of great interest to learn possible synergistic or antagonistic effects of xenoestrogen mixtures on adult organism and during development. The aim of this paper is to review the findings on the association between cancer risk and the endocrine disrupters which directly or indirectly mimic estrogen action.

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Effect of endogenous and exogenous hormones on testicular cancer: the epidemiological evidence

Cited by 66 publications

References 77 publications

Baldness and testicular cancer: the EPSAM case–control study

Baldness and testicular cancer: the EPSAM case–control study

Gender and Age Related Modulation of Xenoestrogen-Induced Tumorigenesis

Gender and Age Related Modulation of Xenoestrogen-Induced Tumorigenesis

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