Effect of endometriosis on implantation rates when compared to tubal factor in fresh non donor in vitro fertilization cycles

Abstract

OBJECTIVE:The objective of the following study is to compare the outcome of in vitro fertilization and embryo transfer (IVF-ET) in women with endometriosis and tubal-factor infertility.DESIGN:Retrospective study.SETTING:Tertiary referral hospital, assisted reproductive technologies unit.MATERIALS AND METHOD:The study group consisted of 78 women diagnosed with advanced stage endometriosis. The control group included 100 women with tubal-factor infertility. These groups were retrospectively analyzed regarding stimulation, fertilization, embryo development, implantation and pregnancy outcome.INTERVENTION (S):Controlled ovarian hyperstimulation and IVF-ET.RESULTS:Lower oocyte yield with lower fertilization rate were found in women with endometriosis compared with tubal-factor control subjects. However, no differences were found in cleavage, implantation and clinical pregnancy rates between the endometriosis and tubal-factor groups.CONCLUSIONS:Our results showed that women with endometriosis have a lower oocyte yield and lower fertilization rate compared with women with tubal-factor infertility. However, once the oocyte is fertilized, it seems that the embryo has a normal chance of implantation, leading to similar pregnancy rates and adequately treated women with endometriosis have equal chances of conception as seen with tubal-factor infertility.

Relationship between resistin and IL-23 levels in follicular fluid in infertile patients with endometriosis undergoing IVF-ET

“…18 In a meta-analysis, Barnhart et al found that the implantation and clinical pregnancy rates were lower in the EM group than in the control group. 1 Similar to these findings, we found that 20 The number of oocytes retrieved and the fertilization rate were significantly lower in the EM group than in the tubal group, but there was no significant difference in the percentage of metaphase II (M2) oocytes, cleavage rate, and percentage of grade 1 embryos formed between the 2 groups. Moreover, the mean number of embryos transferred did not differ between the 2 groups.…”

The sensitivity of the DNA damage checkpoint prevents oocyte maturation in endometriosis

“…Additionally, evidence that reduced fertility in endometriosis is exerted through the oocyte, and not other factors is accumulating4. For instance, implantation and pregnancy rate are not significantly different in patients with endometriosis compared to controls when undergoing IVF and embryo transfer56. Further evidence comes from oocyte donor studies: control donor oocytes were equally likely to implant in patients with endometriosis as without78, whilst oocytes from women with endometriosis were less likely to implant than those without9.…”

Diagnostic and treatment of endometriosis - recommendations for clinical practice

“…U SAD se stopa živorođenosti posle IVF/ET postupaka kod pacijentkinja sa endometriozom kreće oko 39,1%. To je u suprotnosti sa metaanalizama koje pokazuju manju sto-pu trudnoća posle IVF kod pacijentkinja sa infertilitetom uzrokovanim endometriozom nego kod onih sa tubarnim faktorom [7,27]. Osim toga, stopa trudnoća je manja kod onih sa težim formama endometrioze nego kod onih sa minimalnom i blagom endometriozom [7].…”