Effect of Energy Balance on Plasma Glucose and Ketone Bodies in Blood and Milk and Influence of Hyperketonaemia on Milk Production of Postparturient Dairy Cows³

Abstract

Summary The relationship between energy balance, plasma glucose and ketone bodies in blood and milk was investigated during the first eight weeks after calving in 41 clinically healthy Swedish Red and White cows. Ketone bodies in blood and milk and plasma glucose were measured once a week. The mean daily energy intake, milk yield and energy balance during a week were evaluated in relation to ketone bodies and plasma glucose. The least‐squares mean for milk yield reached its peak value in the fourth week of lactation. The energy balance was negative in the first week of lactation and then positive. The energy balance during a week was significantly correlated to plasma glucose and milk acetone plus acetoacetate on the last day of the week. Blood acetone plus acetoacetate, plasma β‐hydroxybutyrate and milk acetone on the first day of a week were significantly correlated to the milk yield during the succeeding week. It is concluded that plasma glucose and milk acetone plus acetoacetate monitor the energy status during the post partum period of dairy cows. It is also suggested that increased concentrations of ketone bodies may cause decreased milk yield in clinically healthy cows. Zusammenfassung Auswirkungen der Energiebilanz auf Plasmaglukose und Ketonkörper in Blut und Milch und Einfluß der Hyperketonämie auf die Milchleistung von postpartalen Milchkühen Während der ersten 8 Wochen post partum wurde bei 41 klinisch gesunden Schwedischen Rotbunten Kühen der Einfluß der Energiebilanz auf die Plasmaglukose und die Ketonkörper in Blut und Milch untersucht. Die Ketonkörper wurden wöchentlich einmal bestimmt. Die durchschnittliche tägliche Energieaufnahme, die Milchleistung und die Energiebilanz während einer Woche wurden beurteilt in Beziehung zu den Ketonkörpern und der Plasmaglukose. Die least‐square Mittelwerte für die Milchleistung erreichten die Gipfelwerte in der vierten Laktationswoche. Die Energiebilanz war in der ersten Laktationswoche negativ und nachher positiv. Die Energiebilanz im Verlaufe einer Woche korrelierte signifikant mit der Plasmaglukose sowie dem Gehalt an Aceton und Acetoacetat in der Milch am letzten Tag der Woche. Die Konzentrationen von Blutaceton und ‐acetoacetat, Plasma‐β‐hydroxybutyrat und Milchaceton am ersten Tag einer Woche korrelierten signifikant mit der Milchleistung während der folgenden Woche. Es wird geschlossen, daß Plasmaglukose und Aceton plus Acetoacetat in der Milch die Energieversorgung der postpartalen Milchkuh widerspiegeln. Es wird ferner angenommen, daß erhöhte Ketonkörperkonzentrationen zu einer Abnahme der Milchleistung bei klinisch gesunden Kühen führen können. Résumé Effet du bilan énergétique sur le glucose du plasma et les corps cétoniques dans le sang et le lait, et influence de l'hypercétonémie sur la production lactée des vaches laitières aprés le vêlage L'influence du bilan énergétique sur le glucose du plasma et les corps cétoniques dans le sang et le lait a été examinée chez 41 vaches tachetées rouges suédoises, cliniquement saines, durant les huit premières ...

Genetic and nongenetic profiling of milk β-hydroxybutyrate and acetone and their associations with ketosis in Holstein cows

“…Inferred associations reflect the physiological processes. In the stage of a negative energy balance and especially for cows with a KET diagnosis, fatty acid oxidation from body fat depots and ongoing ketone production in the liver implies an accumulation of ketone bodies in blood and in milk (Andersson and Lundström, 1984). Results from Table 3 clearly indicate that FTIR milk ketones are useful indicators for the detection of clinical KET in early lactation.…”

Oxidative stress indices in the erythrocytes from lactating cows after treatment for subclinical ketosis with antioxidant incorporated in the therapeutic regime

“…The disease is caused by negative energy balance and manifested by gradual decrease in milk production, inappetance and loss of body weight. The presence of excess ketone bodies in blood and urine without apparent clinical signs is the characteristic of the problem and thus, differs from the clinical ones (Andersson and Lundstrom 1984). Recent studies have shown a close relationship between high body mass index, body weight loss and oxidative stress in human population (Ozata et al 2002;Higdon and Frei 2003;Keaney et al 2003) and a possible relationship between oxidative stress and incidence of metabolic disease has been suggested (Higdon and Frei 2003;Morrow 2003).…”

Evaluation of Diagnostic Methods for Subclinical Ketosis in Dairy Cows

“…Клиникалық белгілерінің байқалмай, денеде кетон денелерінің көп мөлшерде болуы, жасырын немесе субклиникалық кетоз деп есептелінеді. Клиникалық және жасырын кетоздың себептері сиырлардың теріс энергия балансымен байланысты болады [1].…”