Effect of enkephalin and cimetidine on the onset and course of duodenal ulcers in rats

Assessment of the Impact of Some Inhibitors of Angiotensin-converting Ferment, Omeprazole and Their Combinations on the Frequency of Erosive Ulcerous Disorders of Gastric Mucosa When Administered with Indometacin

“…That suggests that sulfhydryls protect mucosal membrane of stomach and that endogen sulfhydryl compounds may mediate gastric cytoprotection induced by prostaglandins (PG). Sulfhydryl groups are necessary for synthesis of prostanoids and activation of PG receptors and may be directly responsible for protection of mucosal membrane affecting permeability of membranes, cellular adhesion and free radicals or they may bind receptors and prevent the release or acting of injury mediators of mucosal membrane [24,25].…”