Effect of enteral feeding with ginger extract in acute respiratory distress syndrome

Ginger ( Zingiber officinale ) prevents severe damage to the lungs due to hyperoxia and inflammation

“…In pathologic specimens, a reduced lamellar body expression pattern indicates severe lung injury that demonstrates decreased type II cells (33,41). In the current study, increased RAC and decreased thickness of the alveolar septa with remarkably reduced fibrosis and decreased SMA immunostaining, as well as better density of the lamellar body protein staining pattern, were present in the ginger-treated group (9)(10)(11)(12)(13)(14)(15)(16)(17)42). Additionally, during the BPD process, increased apoptosis in lung tissue cells has been demonstrated (43).…”

“…Pups in the control group (21% O 2 for 14 days + placebo) and hyperoxia + LPS group (95% O 2 for 14 days + placebo) were administered oral saline (2 mL/kg), but pups in the hyperoxia + LPS + ginger group (95% O 2 for 14 days + ginger) were treated once a day from the first day of the study to the end of the study. In the present experiment, we used whole ginger since many different compounds in ginger have been determined to act in a synergic manner that suggests the importance of using whole ginger (8)(9)(10)(11)(12)(13)(14)(15)(16)(17).…”

Effect of β-glucan on serum level of IL-12, hs-CRP and clinical outcomes in Multiple trauma patients: a prospective randomized study

“…Each patient was evaluated for cardiovascular failure (systolic blood pressure ≤ 90 mmHg or requiring vasopressor support), CNS failure (Glasgow coma score ≤12), coagulation failure, hepatic failure (bilirubin ≥2 mg/dL), and renal failure (serum creatinine ≥2 mg/ dL or 25% increase from the baseline). [24]…”

Ginger extracts influence the expression of IL-27 and IL-33 in the central nervous system in experimental autoimmune encephalomyelitis and ameliorates the clinical symptoms of disease

“…Ginger extract or its pungent constituents, including gingerol and shogaol, are also reported to have antiinflammatory activities in experimental animal models (Lee et al, 2012). The anti-inflammatory effects of ginger and its components have been reported in patients with type 2 diabetes (Priya Rani et al, 2011), osteoarthritis (Drozdov et al, 2012), rheumatoid arthritis (Ramadan and El-Menshawy, 2013), acute respiratory distress syndrome (Vahdat Shariatpanahi et al, 2013), primary dysmenorrheal (Rahnama et al, 2012) and also in experimental models of airway inflammation (Kuo et al, 2011), ulcerative colitis (El-Abhar et al, 2008, neuroinflammation (Ha et al, 2012) and gastric ulcers (Wang et al, 2011).…”