Effect of enterally administered n-3 polyunsaturated fatty acids in acute pancreatitis?a prospective randomized clinical trial

Fatty Acid Composition of Plasma Lipid Classes in Chronic Alcoholic Pancreatitis

“…In our previous study on patients with AP, we randomly assigned participants to receive either fish oil enterally in a dose of 3.3 g/day for 5–7 days, or placebo [5]. Supplementation of fish oil resulted in a significant increase in the ratio of n–3 to n–6 LCPUFA in plasma PL, STE and TG lipids and, more importantly from the clinical point of view, in significant reduction both in the length of hospital stay and that of jejunal feeding [5].…”

“…In AP the first differences if fatty acid status between patients and controls had been outlined [4], thereafter some clinical benefits of enteral [5] as well as parenteral [6,7] administration n–3 LCPUFA were demonstrated in randomized controlled trials. However, the role of an enhanced supply of n–3 LCPUFAs in the treatment of AP remains to be controversial.…”

Nutrition Assessment and Therapy in Acute Pancreatitis

“…Lasztity evaluated whether provision of -3 polyunsaturated fatty acids (-3 PUFA) or fish oil could alter the course of disease in AP through modulation of eicosanoid synthesis. Supplementation of EN with 3.3 g/d of -3 PUFA for 7 days in the treatment group resulted in a significant decrease in hospital LOS (p<0.05) and duration of nutrition therapy (Lasztity N, 2005 …”

“…More recent clinical trials have suggested that EN in comparison to PN may maintain gut integrity, reduce intestinal permeability, and down regulate the systemic immune response syndrome (SIRS), thereby favorably affecting clinical outcome (Jabbar A et al, 2003). Further evidence suggests that not only is the route of feeding a factor in outcome, but specific agents in EN or PN (immune-modulating agents) such as probiotics or -3 fish oil may influence hospital length of stay (LOS) and rate of complications Lasztity N, 2005).…”

Nutritional Support of Dogs and Cats after Surgery or Illness

“…Omega-3 fatty acids decrease muscle loss in dogs with chronic heart failure and improve appetite [70]. Omega-3 fatty acids also are beneficial in animals with atopic dermatitis, [71] osteoarthritis, [72] [73] cancer, [74] errors in lipid metabolism, [75] cardiac disease, [76] [77] kidney disease, [78] and ulcerative colitis [79]. The therapeutic use of long-chain omega-3 fatty acids and fish oils has recently been reviewed [80].…”