Effect of epidermal growth factor on small intestinal sodium/glucose cotransporter–1 expression in a rabbit model of intrauterine growth retardation

Cellini, Christina; Jian, Xu; Buchmiller-Crair, Terry L.

doi:10.1016/j.jpedsurg.2005.08.049

Cited by 7 publications

(5 citation statements)

References 31 publications

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“…Thus, these results support our hypothesis that it is possible to induce a progressive model of fetal growth restriction. It could be argued that fetal position in the uterine horn, which is a 'natural model' of fetal growth restriction [10][11][12][13][14][15][16] , could influence these results. However, we have found that in our model, mortality rate and biometries of growth-restricted fetuses is not influenced by uterine position (results not shown).…”

Section: Discussionmentioning

confidence: 99%

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An Experimental Model of Fetal Growth Restriction Based on Selective Ligature of Uteroplacental Vessels in the Pregnant Rabbit

et al. 2009

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Introduction: To describe an animal model of growth restriction based on selective ligature of uteroplacental vessels in the pregnant rabbit. Material and Methods: Two experimental protocols (+21 and +25 days of gestation) with three groups were defined: controls, mild (20–30%) and severe (40–50%) uteroplacental vessel ligature. Fetuses were delivered 120 h after the procedure by cesarean section. Biometrical measurements were carried out. Brains were obtained and glial response and cell proliferation were studied by S100β and Ki-67 immunohistochemistry. Results: Mortality rate and biometrical restriction increased across experimental groups according to the time and severity of the procedure. S100β expression was significantly higher in the severe reduction group at 25 days. Ki-67 expression was significantly higher in the mild reduction group at 21 days and in the severe reduction group at 25 days. Discussion: Selective ligature of uteroplacental vessels in the pregnant rabbit results in a gradual model of growth restriction in terms of mortality, biometrical restriction and histological brain changes.

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Section: Discussionmentioning

confidence: 99%

“…The rabbit provides a natural model of IUGR based on fetal position within the uterus, but with an uncontrollable and mild effect on birth weight [10][11][12][13][14][15][16] . Food restriction models do not decrease fetal oxygen supply, which may be a critical factor in the pathogenesis of brain injury [17] .…”

Section: Introductionmentioning

confidence: 99%

An Experimental Model of Fetal Growth Restriction Based on Selective Ligature of Uteroplacental Vessels in the Pregnant Rabbit

et al. 2009

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“…However, the intestinal epithelium homeostasis of animals is usually affected by bacterial infection, endotoxin challenge, weaning stress, and oxidative stress, which can lead to intestinal damage and intestinal barrier function dysfunction (73)(74)(75)(76). EGF has been established as a trophic factor for epithelial cell homeostasis (17,18) and nutrient transport in the small intestine (22,58,66,77,78). Previous researches have demonstrated that EGF was able to attenuate the intestinal mucosal epithelial cells injury as well as promotes the repair of damaged mucosa epithelium (18,(79)(80)(81)(82).…”

Section: Egf Promotes Active Transport Of Pi Under Intestinal Injury Conditionmentioning

confidence: 99%

Mechanisms of Epidermal Growth Factor Effect on Animal Intestinal Phosphate Absorption: A Review

Tang

Liu

2021

Front. Vet. Sci.

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Phosphorus is one of the essential mineral elements of animals that plays an important role in animal growth and development, bone formation, energy metabolism, nucleic acid synthesis, cell signal transduction, and blood acid–base balance. It has been established that the Type IIb sodium-dependent phosphate cotransporters (NaPi-IIb) protein is the major sodium-dependent phosphate (Pi) transporter, which plays an important role in Pi uptake across the apical membrane of epithelial cells in the small intestine. Previous studies have demonstrated that epidermal growth factor (EGF) is involved in regulating intestinal Pi absorption. Here we summarize the effects of EGF on active Pi transport of NaPi-IIb under different conditions. Under normal conditions, EGF inhibits the active transport of Pi by inhibiting the expression of NaPi-IIb, while, under intestinal injury condition, EGF promotes the active absorption of Pi through upregulating the expression of NaPi-IIb. This review provides a reference for information about EGF-regulatory functions in Pi absorption in the animal intestine.

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“…The gene expressions of SGLT1 and GLUT2 and active glucose transport of the jejunum increased in the IUGR piglets injected with GLP-2 [13]. Epidermal growth factor infusion significantly increased the small intestinal SGLT-1 protein expression in IUGR fetuses vs. controls but did not affect the SGLT-1 mRNA expression [25]. H⁺-coupled transporter, peptide transporter 1 (PEPT1) is responsible for the uptake of dietary dipeptides and tripeptides in the intestines; in addition, peptide transport in the small intestines is important during the first week of suckling [26].…”

Section: Pglp-2 Microspheres Improve the Pancreatic Secretion Functiomentioning

confidence: 99%

Catch-up Growth in Intrauterine Growth-restricted Piglets Associated with the Return of Pancreatic and Intestinal Functions via Porcine Glucagon-like peptide-2 Microspheres

Zhou

et al. 2020

Preprint

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Background Intrauterine growth restriction (IUGR) results in abnormal morphology and gastrointestinal function. As a gastrointestinal growth factor, the manner by which the porcine glucagon-like peptide-2 (pGLP-2) microsphere administration catches up with the growth of IUGR piglets was investigated. Methods Fourteen newborn IUGR piglets were assigned into the IUGR and pGLP-2 microsphere groups. The piglets in the pGLP-2 microsphere group were intraperitoneally administered with 100 mg of pGLP-2 microspheres on day 1 of birth. Results From days 15 to 26 of trial, the body weight of the IUGR piglets treated with pGLP-2 microspheres was significantly higher than that in the control group. Importantly, the weaning weight in the pGLP-2 group catches up with the body weight of normal birth weight piglets. IUGR piglets treated with pGLP-2 microspheres significantly showed increased pancreas weight, serum insulin content, and activities of digestive enzymes (lipase, trypsin, chymotrypsin, and amylase). Injection of pGLP-2 microspheres returned the intestinal absorptive capacity by significantly increasing the mRNA expression of sodium-glucose cotransporter 1 in the jejunum, glucose transporter type 2 in the duodenum and jejunum, H + -coupled transporter, and peptide transporter 1 in the jejunum and ileum. It also returned the redox balance by increasing the catalase mRNA expression and decreasing the heat shock protein 70 mRNA expression. In addition, this improvement was associated with the significant increase in gut diameter, length, and weight induced by pGLP-2. Conclusions Injection of pGLP-2 microspheres was a suitable therapeutic strategy for compensatory growth in low birth weight IUGR piglet.

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Effect of epidermal growth factor on small intestinal sodium/glucose cotransporter–1 expression in a rabbit model of intrauterine growth retardation

Cited by 7 publications

References 31 publications

An Experimental Model of Fetal Growth Restriction Based on Selective Ligature of Uteroplacental Vessels in the Pregnant Rabbit

An Experimental Model of Fetal Growth Restriction Based on Selective Ligature of Uteroplacental Vessels in the Pregnant Rabbit

Mechanisms of Epidermal Growth Factor Effect on Animal Intestinal Phosphate Absorption: A Review

Catch-up Growth in Intrauterine Growth-restricted Piglets Associated with the Return of Pancreatic and Intestinal Functions via Porcine Glucagon-like peptide-2 Microspheres

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