2000
DOI: 10.1097/00003643-200001000-00010
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Effect of epidural and intravenous clonidine on the neuro-endocrine and immune stress response in patients undergoing lung surgery

Abstract: increased in all groups at the end of surgery, but the increase was least in the epidural clonidine group. The effects of intravenous and epidural clonidine, The number of lymphocytes was reduced at the end 4 g kg −1 , combined with epidural morphine, of surgery in the epidural and intravenous group, 40 g kg −1 , on the neuro-endocrine and immune stress compared with the control group in which the number responses to thoracic surgery are reported. A control of lymphocytes did not change. The effects are more g… Show more

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Cited by 10 publications
(3 citation statements)
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“… 21 , 22 In addition to the choice of anaesthetic, different regional techniques (epidural, paravertebral anaesthesia) also influence perioperative inflammation depending on the anaesthetics used. 23 , 24 …”
Section: Pathophysiology Of Metastasismentioning
confidence: 99%
See 1 more Smart Citation
“… 21 , 22 In addition to the choice of anaesthetic, different regional techniques (epidural, paravertebral anaesthesia) also influence perioperative inflammation depending on the anaesthetics used. 23 , 24 …”
Section: Pathophysiology Of Metastasismentioning
confidence: 99%
“…21,22 In addition to the choice of anaesthetic, different regional techniques (epidural, paravertebral anaesthesia) also influence perioperative inflammation depending on the anaesthetics used. 23,24 Transfusion of blood derivatives reduces the number of T-cytotoxic leukocytes, TNF production and macrophage chemotaxis. 25 Finally, the central nervous system also has an effect on perioperative stress and the immune response, which is the subject of psychoneuroimmunology.…”
Section: The Effect Of Anaesthetics and Anaesthetic Technique On Infl...mentioning
confidence: 99%
“…On the other hand, prolonged or intense stimulation of these systems can be the cause of chronic or neuropathic pain ( 1 ). Immune response was reduced (decreased number of leucocytes, segmental neutrophils and lymphocytes) when clonidine was used as additive to epidural mixture lung surgery ( 8 ).…”
Section: Pain and Immune Response To Surgical Stressmentioning
confidence: 99%