Effect of Epinephrine Delivered Endotracheally in a Surfactant Based Aerosol via Metered Dose Inhaler (MDI) Compared to Instillation in Normal and Shock Rabbit Models • 373

Caballes-Ponce, Marie Grace; Davidson, Melissa; Skurnick, Joan; Mautone, Alan J.

doi:10.1203/00006450-199804001-00394

Cited by 4 publications

(4 citation statements)

References 18 publications

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“…3 A synthetic surfactant aerosol prepared in a meter dose inhaler has been demonstrated to be effective in reducing surface tension and restoring lung function in an acute lung injury model. [16][17][18][19] A much higher concentration of dry aerosolized surfactant can be delivered per metered dose than with a nebulizer delivery system. The physicochemical characteristics of aerosolized metered dose surfactant strongly indicate that it can act as an ideal preparation to spread rapidly over the mucosal surface of the ET, thereby lowering its lining layer surface tension.…”

Section: Objectivementioning

confidence: 99%

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Dosage Regimens of Intranasal Aerosolized Surfactant on Otitis Media with Effusion in an Animal Model

Venkatayan

Connelly

Mautone

et al. 2001

Otolaryngol.--head neck surg.

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Section: Objectivementioning

confidence: 99%

“…A synthetic surfactant aerosol prepared in a meter dose inhaler has been demonstrated to be effective in reducing surface tension and restoring lung function in an acute lung injury model 16–19 …”

mentioning

confidence: 99%

Dosage Regimens of Intranasal Aerosolized Surfactant on Otitis Media with Effusion in an Animal Model

Venkatayan

Connelly

Mautone

et al. 2001

Otolaryngol.--head neck surg.

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“… 20 A more concentrated amount of medication can be delivered per metered dose when it is not suspended in an aqueous medium. 21 Aerosolized spray form delivers 3.5 to 4 mg of the 25 mg DPPC and 0.125 mg CP mixture per actuated spray with greater than 90% efficiency; nebulized solution of 35 mg/ml delivers at only 8% efficiency per spray. The synthetic surfactant used for the current experiments has the added advantage of not originating in animal lung and therefore avoiding the cost and potential health concerns associated with that formulation.…”

Section: Introductionmentioning

confidence: 99%

Otitis Media: Treatment With Intranasal Aerosolized Surfactant

Chandrasekhar

Mautone

2004

The Laryngoscope

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“… 6–9 In an acute lung injury model, surfactant, the common form of lecithin, delivered via metered dose inhaler (MDI) 10 is effective in reducing lung surface tension and restoring function. 11–13 Surfactant functions as an ideal preparation, as it spreads rapidly over the eustachian tube mucosal surface to lower its lining layer surface tension, thereby allowing the tube to open more easily. Its effect is based on Laplace's law 14 [pressure = 2(surface tension/radius)] which defines the forces needed to open the eustachian tube and prevent collapse.…”

Section: Introductionmentioning

confidence: 99%

Intranasal Surfactant Aerosol Therapy for Otitis Media With Effusion

et al. 2000

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Objective: To determine the effect of surfactant alone and with other medications delivered intranasally as a metered dose inhaler (MDI) aerosol on the resolution of experimentally induced otitis media with effusion (OME). Background: Eustachian tube dysfunction is a primary factor in the pathogenesis of OME. Intranasal surfactant via MDI has been shown in this laboratory to reduce passive opening pressure of the eustachian tube in normal gerbils and mice. Study Design: OME was developed in 35 gerbils by transtympanic injection of 10 g lipopolysaccharide from Klebsiella pneumoniae. Pretreatment otomicroscopy and tympanometry were performed to exclude pre-existing middle ear disease, and postinfection evaluations were performed on alternate days for a period of 30 days. Five animals received no treatment (control group); four were treated with propellant only (placebo); seven received surfactant alone; eight received surfactant and betamethasone; and six received surfactant with phenylephrine. All medications were sprayed intranasally as an aerosolized MDI and administered daily from postinfection day 2 onward. Results: OME resolved after 16.0 ؎ 0.44 days (mean ؎ SD) in controls. There was no difference seen in the placebo or the surfactant with phenylephrine groups. Treatment with surfactant yielded resolution in 10.57 ؎ 0.37 days; this was reduced to 8.57 ؎ 0.37 days with surfactant plus betamethasone. These differences are statistically significant. There was no recurrence of OME in any group. Conclusion: This study demonstrates that using an aerosolized MDI surfactant with and without betamethasone decreases the duration of OME in this in vivo gerbil model. Key Words: Surfactant, otitis media with effusion, gerbil, aerosolized metered dose inhaler, eustachian tube dysfunction.

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Effect of Epinephrine Delivered Endotracheally in a Surfactant Based Aerosol via Metered Dose Inhaler (MDI) Compared to Instillation in Normal and Shock Rabbit Models • 373

Cited by 4 publications

References 18 publications

Dosage Regimens of Intranasal Aerosolized Surfactant on Otitis Media with Effusion in an Animal Model

Dosage Regimens of Intranasal Aerosolized Surfactant on Otitis Media with Effusion in an Animal Model

Otitis Media: Treatment With Intranasal Aerosolized Surfactant

Intranasal Surfactant Aerosol Therapy for Otitis Media With Effusion

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