Effect of EPOC on Serum MicroRNA Expression in Patients with Hypertension

Abstract

In order to analyze the effect of EPOC on serum microRNA expression in patients with hypertension, we have carried out an experimental evaluation and presented a dedicated method to improve its effectiveness. For this purpose, 60 patients with hypertension treated in our hospital from January to December 2020 were selected and randomly divided into the EPOC group (30 cases) and the control group (30 cases). Patients in both groups received conventional hypertension medication according to the treatment guidelines, and education and guidance were strengthened to ensure patients’ drug compliance. The EPOC group received EPOC training in addition to conventional medication. After the intervention, 6MWD, LVEF, and LVEDD in the control group and the EPOC group were significantly improved compared with that before treatment ( P < 0.05). The improvement of cardiac function in the EPOC group was significantly better than that in the control group ( P < 0.05). Physiological function, physiological characteristics, body pain, and general health of the control group and the EPOC group were significantly improved compared with that before treatment ( P < 0.05). The improvement of quality of life in the EPOC group was significantly better than that in the control group ( P < 0.05). The indexes of heart rate, oxygen pulse, minute ventilation, oxygen uptake in kg, and anaerobic threshold in the EPOC group were significantly better than those in the control group before and after treatment ( P < 0.05). Full-sample real-time PCR verification of the 8 miRNAs with the highest expression differentiation showed that, compared with the control group, the expression levels of miR-20a-5p, miR-93-5p, and miR-1287-5p in the serum of the EPOC group were significantly increased, while the expression levels of miR-7706, miR-28-5p, and miR-125b-5p were significantly decreased. The expression of miR-20a-5p was the highest, while the expression of miR-125b-5p was the lowest, suggesting that miR-20a-5p and miR-125b-5p might be involved in the process of HIIT to improve hypertension. After EPOC rehabilitation treatment, patients’ heart function indexes, lung function indexes, and quality of life have been significantly improved. EPOC rehabilitation can improve exercise tolerance, enhance cardiopulmonary function, and improve the prognosis of patients.

Genetic and Epigenetic Mechanisms Regulating Blood Pressure and Kidney Dysfunction

“…153 Human patients with hypertension subjected to postexercise oxygen intake showed increased expression of miR-200-5p with decreased BP. 154 Genetic data suggest that polymorphisms in certain LncRNAs, including rs133049, rs10757274, rs2383207, and rs10757278, were found to increase the risk of hypertension. 155 Similarly, the expression of the LncRNA NR-104 181 is associated with a high burden of hypertension in human patients.…”

“… 153 Human patients with hypertension subjected to postexercise oxygen intake showed increased expression of miR-200-5p with decreased BP. 154 …”

Exercise Training-Induced MicroRNA Alterations with Protective Effects in Cardiovascular Diseases

“…A clinical study has shown that EPOC training can upregulate the expression of miR-20a-5p and downregulate the expression of miR-125b-5p. miR-20a-5p and miR-125b-5p have been found to be involved in the improvement of hypertension using high-intensity interval training [ 118 ]. miR-132-3p can be used as a therapeutic target for HF as demonstrated by a preclinical trial using an antimiR-132-3p treatment regimen, which shows a high clinical potential with excellent pharmacokinetics, safety, tolerability, and dose-dependent pharmacokinetics/pharmacodynamics (PK/PD) relationship [ 97 ].…”

Retracted: Effect of EPOC on Serum MicroRNA Expression in Patients with Hypertension

“…Journal of Healthcare Engineering has retracted the article titled “Effect of EPOC on Serum MicroRNA Expression in Patients with Hypertension” [ 1 ] due to concerns that the peer review process has been compromised.…”

“…Journal of Healthcare Engineering has retracted the article titled "Efect of EPOC on Serum MicroRNA Expression in Patients with Hypertension" [1] due to concerns that the peer review process has been compromised. Following an investigation conducted by the Hindawi Research Integrity team [2], signifcant concerns were identifed with the peer reviewers assigned to this article; the investigation has concluded that the peer review process was compromised.…”