Effect of Eriobotrya japonica on Adipogenesis and Body Weight

Oh, Jeongseog; Min, Oh-Jin; Kim, Hyeon-A; Kim, Yong Jae; Baek, Hum Young; Rhyu, Dong Young

doi:10.3839/jksabc.2011.060

Cited by 9 publications

(4 citation statements)

References 25 publications

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“…Its leaves are used as the ingredient of tasty teas called as “Biwa cha” in Japanese. It has been reported that the extracts of the leaves from E. japonica exerted an antiobesity effect through regulation of plasma lipid and adiponectin levels in mice and adipogenic transcription factors PPARγ and C/EBPα in 3T3-L1 adipocytes . Also, the leaves of E. japonica were reported to have a potent inhibitory effect on the inflammatory mediator via the attenuation of NF-κB translocation to the nucleus …”

Section: Introductionmentioning

confidence: 99%

“…It has been reported that the extracts of the leaves from E. japonica exerted an antiobesity effect through regulation of plasma lipid and adiponectin levels in mice and adipogenic transcription factors PPARγ and C/ EBPα in 3T3-L1 adipocytes. 1 Also, the leaves of E. japonica were reported to have a potent inhibitory effect on the inflammatory mediator via the attenuation of NF-κB translocation to the nucleus. 2 E. japonica significantly delayed carcinogenesis induced by peroxynitrite (initiator) and TPA (promoter), and its potency was comparable to that of a green tea polyphenol, (−)-epigallocatechin 3-O-gallate, in the same assay.…”

Section: ■ Introductionmentioning

confidence: 99%

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Inhibitory Effects of the Leaves of Loquat (Eriobotrya japonica) on Bone Mineral Density Loss in Ovariectomized Mice and Osteoclast Differentiation

Tao

Furuta

Nagata

et al. 2014

J. Agric. Food Chem.

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The loquat, Eriobotrya japonica Lindl. (Rosaceae), is a small tree native to Japan and China that is widely cultivated for its succulent fruit. Its leaves are used as an ingredient of a tasty tea called "Biwa cha" in Japanese. The anti-osteoporosis effects of the leaves of loquat in vitro and in vivo have been investigated. After 15 days of feeding normal diet or diet supplemented with 5% loquat leaves, the body weight, viscera weights, and bone mineral density (BMD) of both groups of eight ovariectomized (OVX) mice were compared. The result showed that the loss of BMD in loquat-fed mice was significantly prevented in three parts of the body, especially in the trabecular bone of the head (P < 0.05), abdomen (P < 0.01), and lumbar (P < 0.05) compared to the control group. No hypertrophy in the uterus by the loquat leaves diet was observed. The effect of the extract (447.25 g) prepared from the dried leaves of loquat (2.36 kg) was further studied on RANKL-induced osteoclast differentiation and cell viability. The extract suppressed the differentiation of osteoclasts under 50, 125, 250, and 500 μg/mL. Through bioactivity-guided fractionation, ursolic acid (1) was isolated and inhibited osteoclast differentiation under 4 and 10 μg/mL. It was concluded that loquat leaves possess the potential to suppress ovariectomy-induced bone mineral density deterioration.

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Section: Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Inhibitory Effects of the Leaves of Loquat (Eriobotrya japonica) on Bone Mineral Density Loss in Ovariectomized Mice and Osteoclast Differentiation

Tao

Furuta

Nagata

et al. 2014

J. Agric. Food Chem.

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“…A fruit tree known as Eriobotrya japonica has been employed in traditional medicine for its therapeutic effects [146]. Using animals fed a high-fat diet, EJ extracts have been shown to control adipogenesis and body weight gain [147], reduce hyperglycemia in type II diabetic rats and mice [148], and improve hyperlipidemia and insulin resistance. Furthermore, the ameliorative ability of EJ seed extract (70% ethanol) against experimentally produced NASH was examined.…”

Section: Loquat (Eriobotrya Japonica)mentioning

confidence: 99%

Natural Products for the Treatment of Non-Alcoholic Fatty Liver Disease: A Comprehensive Review

Nucera,

Bulotta,

Ruga

et al. 2023

Sci. Pharm.

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Plants are an untapped natural resource; their secondary metabolites take part in a variety of pharmacological activities, making them an essential ingredient in the synthesis of novel medications and the source of reserve resources in this process. Hepatitis and liver cancer are two conditions that can result from non-alcoholic fatty liver disease (NAFLD). NAFLD is a condition that now affects a significant section of the global population. There is a need for preventative action on predisposing factors. Due to their effectiveness and few side effects, herbal medications are frequently utilized for the prevention and treatment of NAFLD. This review discusses the pathogenetic processes of NAFLD and the evidence brought to support the potential of botanical species and their derivatives in limiting the causes that predispose to the onset of NAFLD.

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“…Eriobotrya japonica (EJ; family: Rosaceae) is a fruiting tree whose leaves have been used in traditional Kampo and Chinese medicinal system [ 107 ]. Extracts of EJ have been shown to improve hyperlipidemia and insulin resistance, regulate adipogenesis and body weight gain in high fat diet-fed mice [ 110 ], and reduce hyperglycemia in type II diabetic rats and mice [ 111 ]. Also, the EJ seed extract (70% ethanol) has been put to scrutiny to assess its ameliorative property against experimentally induced NASH.…”

Section: Natural Products For the Treatment Of Nashmentioning

confidence: 99%

Herbal Medicines for the Treatment of Nonalcoholic Steatohepatitis: Current Scenario and Future Prospects

Jadeja

Devkar

Nammi

2014

Evidence-Based Complementary and Alternative Medicine

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Nonalcoholic steatohepatitis (NASH) is a multifactorial disease and has close correlations with other metabolic disorders. This makes its treatment difficult using a single pharmacological drug. Use of plant extract/decoction or polyherbal formulation to treat various liver diseases is very well mentioned in various traditional systems of medicine (Ayurveda, Japanese or traditional Chinese Medicine, and Kampo medicine). Medicinal herbs are known for their multifaceted implications and thus can form an effective treatment schedule against NASH. Till date, several plant extracts, polyherbal formulations, and phytochemicals have been evaluated for their possible therapeutic potential in preventing onset and progression of NASH in experimental models, but clinical studies using the same are sparse. Herbal extracts with antioxidants, antidiabetic, and antihyperlipidemic properties have been shown to ameliorate symptoms of NASH. This review article is a meticulous compilation of our current knowledge on the role of natural products in alleviating NASH and possible lacunae in research that needs to be addressed.

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Effect of Eriobotrya japonica on Adipogenesis and Body Weight

Cited by 9 publications

References 25 publications

Inhibitory Effects of the Leaves of Loquat (Eriobotrya japonica) on Bone Mineral Density Loss in Ovariectomized Mice and Osteoclast Differentiation

Inhibitory Effects of the Leaves of Loquat (Eriobotrya japonica) on Bone Mineral Density Loss in Ovariectomized Mice and Osteoclast Differentiation

Natural Products for the Treatment of Non-Alcoholic Fatty Liver Disease: A Comprehensive Review

Herbal Medicines for the Treatment of Nonalcoholic Steatohepatitis: Current Scenario and Future Prospects

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