Effect of Erythropoietin on Postresuscitation Renal Function in a Swine Model of Ventricular Fibrillation

Pantazopoulos, Charalampos; Iacovidou, Nicoletta; Kouskouni, Evangelia; Pliatsika, Paraskevi; Papalois, Αpostolos; Kaparos, George; Barouxis, Dimitrios; Vasileiou, Panagiotis; Lelovas, Pavlos; Kotsilianou, Olympia; Pantazopoulos, Ioannis; Gkiokas, Georgios; Garosa, Clara; Faa, Gavino; Xanthos, Theodoros

doi:10.1155/2016/3567275

Cited by 3 publications

(2 citation statements)

References 49 publications

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“…EPO is a potent angiogenic factor which is important in diabetes and some cancers (including breast cancer (9)). When activated in specific conditions, its angiogenic activity prevents tissue ischemia damages (12)(13)(14)(15)(16)(17)(18)(19)(20)(21). Over-expression of At the first step we investigated the frequencies of different genotypes (including GG (normal), GT (heterozygote) and TT (mutant)) between controls (150 healthy individuals without diabetes and with no family history for the disease) and patients (150 with diabetes) groups.…”

Section: Discussionmentioning

confidence: 99%

Investigating the Association of rs1617640 Polymorphism in Patients with Diabetes Type II and Its Complications

et al. 2017

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: The prevalence of diabetes – especially diabetes type II- is increasing steadily; according to WHO reports it will increase to 366 million people by the year 2030. Microvascular complications including Proliferative diabetic retinopathy (PDR) and end stage renal disease (ESRD) are increased in patients with diabetes mellitus. Case-control association studies have demonstrated that rs1617640 SNP in the promoter of erythropoietin (EPO) gene is significantly associated with PDR and ESRD. In the mentioned SNP, TT genotype is considered as risk genotype which means that EPO concentration in human vitreous body in these people shall be higher. People with TT genotype are much more at risk of retinopathies. In this study we investigated the existence of rs1617640 EPO gene polymorphism among 150 healthy subjects and 150 subjects with diabetes type II who referred to Yazd central laboratory. Then the association of rs1617640 SNP with complications among diabetic patients were examined by ARMS-PCR method. The results were analyzed using GraphPad software (version 5.00). Prevalence of genotype GG was 8% in patients and 1.3% in the control group. GT was 51.3% in patients, and 86.7% in the control group, and finally TT was observed in 40.7% in patients, and 12% of control group. The TT genotype was 37.6% in patients with retinopathy and 42.6% in non-retinopathy patients. Our study demonstrates that the prevalence of rs1617640 SNP has significant difference between diabetic patients and control group; whereas there was not any significant relationship between this polymorphism and the complications of diabetes in patients. Together our study reveals that rs1617640 SNP may be associated with susceptibility to diabetes type II; however it seems that this polymorphism is not significantly related to the diabetic complications in Yazd.

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Section: Discussionmentioning

confidence: 99%

Investigating the Association of rs1617640 Polymorphism in Patients with Diabetes Type II and Its Complications

et al. 2017

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“…Electrical induction via two subcutaneous needles 50 ± 0 53.3 ± 6.0 46.9 ± 14.9 *One study was not included as it has 1,003 mA and 603 Hz which may be due to publication error [14] . Ten studies uses 9-V battery for electrical induction [15][16][17][18][19][20][21][22][23][24][25][26] . SD: standard deviation.…”

Section: Author Contributionsmentioning

confidence: 99%

Systematic review of swine models for ventricular fibrillation induction in evaluating cardiopulmonary resuscitation methods

Low,

Azahar,

Samson

et al. 2024

Cardiology Plus

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Background and purpose: Ventricular fibrillation (VF) has been studied using a variety of swine models, historically balloon occlusion of the coronary artery and asphyxiation, and more recently, percutaneous electrical induction. These methods differ in face and construct validity, as well as requirement for expertise, cost, and duration. This study aimed to provide a systematic review these methods and their selection in research. Methods: Electronic searches were conducted in PubMed, Scopus, and Google Scholar. The Utstein-Style Guidelines for Uniform Reporting of Laboratory cardiopulmonary resuscitation (CPR) research were used to identify the extracted variables by two independent investigators. Discrepancy was resolved by discussion with the third investigator. Results: We included 236 studies published from 1990 to 2024. The most commonly used method was electrical induction using a pacing wire cannulated through the external jugular vein into the right ventricle (n = 112), followed by transthoracic electrical induction (n = 28), asphyxiation (n = 20), electrical induction via two subcutaneous needles (n = 15), and balloon occlusion (n = 10). The mean and standard deviation (SD) of the untreated VF duration were 6.9 and 5.0 minutes, respectively. Female and male pigs were used exclusively in 52 and 45 studies, respectively; both sexes were used in 31 studies; 106 studies not reporting the sex. The mean weight of the pigs was 30.2 ± 12.4 kg in 209 studies, and the number of pigs used in the studies ranged from 2 to 271 with a median of 20 (interquartile range: 15–30) pigs in 223 studies. The four most commonly used drugs for anesthesia/preparation were ketamine (n = 145), propofol (n = 76), isoflurane (n = 68), and pentobarbital (n = 61), either alone or in combination. Higher current and voltage were used for less invasive methods. Conclusions: The two most common electric method to induce VF were invasive pacing at the right ventricle and non-invasive transthoracic electrical induction. Asphyxiation was the most common ischemic VF induction. The choice of the VF induction method depends on cost, expertise, feasibility, and the nature of the CPR intervention to be tested.

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Stress hormones kinetics in ventricular fibrillation cardiac arrest and resuscitation: Translational and therapeutic implications

Pantazopoulos

Boutsikos

Mavrovounis

et al. 2021

The American Journal of Emergency Medicine

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Effect of Erythropoietin on Postresuscitation Renal Function in a Swine Model of Ventricular Fibrillation

Cited by 3 publications

References 49 publications

Investigating the Association of rs1617640 Polymorphism in Patients with Diabetes Type II and Its Complications

Investigating the Association of rs1617640 Polymorphism in Patients with Diabetes Type II and Its Complications

Systematic review of swine models for ventricular fibrillation induction in evaluating cardiopulmonary resuscitation methods

Stress hormones kinetics in ventricular fibrillation cardiac arrest and resuscitation: Translational and therapeutic implications

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