Effect of Erythropoietin Therapy on the Lipid Profile in Patients with Chronic Kidney Disease – A Single Center Study

Al-Saedi, Ali J Hashim; Alwachi, Sabah N.; Karim, Abdul

doi:10.4172/2161-0959.1000140

J Nephrol Ther

2013

DOI: 10.4172/2161-0959.1000140

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Effect of Erythropoietin Therapy on the Lipid Profile in Patients with Chronic Kidney Disease – A Single Center Study

Ali J Hashim Al-Saedi¹,

Sabah N. Alwachi²,

Abdul Karim³

Abstract: Dyslipidemia is common in chronic kidney disease patients and alterations in serum lipid profile vary widely depending on the level of kidney function. We studied two hundred Iraqi patients who were diagnosed as having chronic kidney disease from June 2011 to January 2013. They were given erythropoietin for seven months. One hundred sixty patients (80%) showed response to treatment with an improvement in lipid profile, while the other 40 patients (20%) showed no significant response to treatment. In conclusion… Show more

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2021

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MiRNA and Erythropoietin profiles during the menstrual cycle in relation to hematological and lipid biomarkers

Bergström

Heiland

Björkhem‐Bergman

et al. 2021

Preprint

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BackgroundCirculatory micro RNAs (miRNA) have been discussed as complementary diagnostic markers in cardiovascular diseases, and in anti-doping testing. MiR-144 and miR-486 have been associated with cholesterol homeostasis and hematopoiesis, respectively. In addition, they have been suggested as putative biomarkers for autologous blood transfusion and erythropoietin (EPO) doping. The aim of the present study was to assess the variability of miR-144-3p/5p, miR-486-5p/3p and EPO during the menstrual cycle. Secondary aim was to study the correlations between miRNAs, EPO and hematological parameters and lipids.Methods13 healthy women with regular menses were followed with weekly blood sampling during two whole menstrual cycles. MiRNAs were analyzed using TaqMan and PCR followed by calculation of the relative expression for each miRNA using ddCT approach.ResultsThere was no menstrual cycle variability in miRNAs and EPO. MiRNA-144-3p was associated with HDL-C (rs=-0.34, p=0.036) and miRNA-486-5p with Hb (rs=0.32, p=0.046). EPO concentrations correlated to lymphocytes (rs=-0.062, p=0.0002)), Hb (rs= -0.42, p=0.0091), HDL-C (rs=0.36, p=0.030) and triglycerides (rs=-0.54, p=0.0006).ConclusionsThe results of this study may increase the understanding of how miR486-5p and miR144-3p as well as EPO correlate to hematopoietic and lipid biomarkers.

show abstract

MiRNA and Erythropoietin profiles during the menstrual cycle in relation to hematological and lipid biomarkers

Bergström

Heiland

Björkhem‐Bergman

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

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Effect of Erythropoietin Therapy on the Lipid Profile in Patients with Chronic Kidney Disease – A Single Center Study

Cited by 1 publication

References 20 publications

MiRNA and Erythropoietin profiles during the menstrual cycle in relation to hematological and lipid biomarkers

MiRNA and Erythropoietin profiles during the menstrual cycle in relation to hematological and lipid biomarkers

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