Effect of erythropoietin therapy on the progression of cisplatin induced renal injury in rats

Mohamed, H. E.; Elswefy, Sahar E; Mohamed, Rasha H.; Ghanim, Amal M H

doi:10.1016/j.etp.2011.08.006

Cited by 31 publications

(30 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This finding is consistent with earlier studies where GSH depletion was suggested to result from interaction between cisplatin and biomolecules containing sulphydryl groups (Khoshnoud et al, 2011;Mohamed et al, 2013). Likewise, the reduced kidney vitamin C content in the cisplatin administered rats may be related to depleted GSH storage because, GSH is necessary for the recycling of vitamin C (Murray et al, 2003).…”

Section: Groupsupporting

confidence: 82%

Dietary inclusion of sorghum (Sorghum bicolour) straw dye protects against cisplatin-induced nephrotoxicity and oxidative stress in rats

Ademiluyi

Oboh

Agbebi

et al. 2014

Pharmaceutical Biology

View full text Add to dashboard Cite

Context: Sorghum straw (dried leaves and stem fiber) extracts and infusion are employed in the management of several ailments in folklore, and it is also a natural dye source used in food preparation.Objective: This study sought to investigate the modulatory effect of dietary inclusion of Sorghum straw dye on cisplatin-induced nephrotoxicity and antioxidant status in rats. Materials and methods: Adult male rats were randomly divided into four groups of six animals each. Groups I (normal rats) and II (control rats) were fed with basal diet while Groups III and IV were fed with diets containing 0.5% and 1% sorghum straw dye, respectively. Nephrotoxicity was induced in Groups I-IV on the 20th day by the administration of a single dose of cisplatin solution (7 mg/kg body weight, i.p.) and the experiment was terminated 3 d after. Thereafter, the kidney and plasma of the rats were analyzed for kidney function (creatinine, urea, uric acid, and blood urea nitrogen) and antioxidant indices [superoxide dismutase (SOD), catalase, glutathione-S-transferase (GST), malondialdehyde (MDA), vitamin C, and reduced glutathione (GSH)]. Results: The average feed intake of the rats in all the groups ranged from 9.0 to 9.5 (g/rat/day). Furthermore, the result indicated that administration of cisplatin caused significant (p50.05) elevation in plasma creatinine (2.2 mg/dL), uric acid (39.3 mg/dL), urea (81.4 mg/dL), and blood urea nitrogen (38.0 mg/dL) as well as a concomitant decrease in kidney antioxidant indices in control rats as against the normal rats. However, diets supplemented with 0.5 and 1.0% sorghum straw dye significantly reversed the plasma creatinine and the kidney antioxidant indices to near normal levels. Discussion and conclusion: The study suggests that dietary inclusion of sorghum straw dye as colorants could protect against oxidative stress and cisplatin-induced nephrotoxicity.

show abstract

Section: Groupsupporting

confidence: 82%

Dietary inclusion of sorghum (Sorghum bicolour) straw dye protects against cisplatin-induced nephrotoxicity and oxidative stress in rats

Ademiluyi

Oboh

Agbebi

et al. 2014

Pharmaceutical Biology

View full text Add to dashboard Cite

show abstract

“…CDDP resulted in significant tubular damage[28] and oxidative stress involved in kidney damage after CDDP administration. [30] The nephrotoxic effect of CDDP is related to its uptake by proximal tubular cells.…”

Section: Discussionmentioning

confidence: 99%

Effects of fennel essential oil on cisplatin-induced nephrotoxicity in ovariectomized rats

Mazaheri¹,

Nematbakhsh²,

Bahadorani³

et al. 2013

Toxicol Int

View full text Add to dashboard Cite

Background:Cisplatin (cis-diamminedichloroplatinum II (CDDP)) is an effective drug in cancer therapy to treat solid tumors. However, the drug is accompanied by nephrotoxicity. Previous reports indicated that estrogen has no protective role against CDDP-induced nephrotoxicity, but the role of phytoestrogen as an estrogenic agent in plants is not determined yet. The major composition of fennel essential oil (FEO) is trans-anethole that has estrogenic activity; so, we used FEO as a phytoestrogen source against CDDP-induced nephrotoxicity.Materials and Methods:Fifty-four ovariectomized Wistar rats were divided into seven groups. Groups 1-3 received different doses of FEO (250, 500, and 1000 mg/kg/day, respectively) for 10 days. Group 4 received saline for 10 days plus single dose of CDDP (7 mg/kg, intraperitoneally (ip)) at day 3. Groups 5-7 received FEO similar to groups 1-3, respectively; plus a single dose of CDDP (7 mg/kg, ip) on day 3. On day 10, the animals were sacrificed for histopathological studies.Results:The serum levels of blood urea nitrogen (BUN) and creatinine (Cr), kidney tissue damage score (KTDS), and kidney weight (KW) and body weight changes in CDDP-treated groups increased significantly (P < 0.05). FEO did not reduce the levels of BUN and Cr, KTDS, and KW and body weight changes. Also, the serum and tissue levels of nitrite were not altered significantly by FEO.Conclusion:FEO, as a source of phytoestrogen, did not induce kidney damage. In addition, FEO similar to estrogen was not a nephroprotectant agent against CDDP-induced nephrotoxicity.

show abstract

“…The demonstrated presence of EPO receptor in nonhematopoietic tissues has led researchers to examine the potential beneficial effects of EPO, apart from its hematopoietic function, and the cytoprotective effects of EPO have been demonstrated extensively in various tissues. In these studies, rhEPO (recombinant human erythropoietin) has been found to be protective against both ischemic and toxic injuries, such as ischemic brain and myocardial injury [12,13] and CDDP-induced kidney and liver injury [14,15] . In addition, it has also been demonstrated that EPO and its receptors are widely expressed in several cell types within the cochlea, and EPO was found to be protective against gentamicin-induced hair cell damage in rat cochlea cell lines [16] .…”

Section: Introductionmentioning

confidence: 99%

The Protective Effect of Recombinant Human Erythropoietin against Cisplatin-Induced Ototoxicity

Doğan¹,

Olgun²,

Kırkım³

et al. 2015

Int Adv Otol

View full text Add to dashboard Cite

OBJECTIVE:To investigate the potential protective effect of recombinant human erythropoietin (rhEPO) against cisplatin-induced ototoxicity. MATERIALS and METHODS:Twenty-eight Wistar albino rats were divided randomly into four groups, and baseline distortion product otoacoustic emission (DPOAE) responses and auditory brainstem response (ABR) thresholds were obtained. Group I received intraperitoneal (i.p.) saline, Group II received a single dose of i.p. 2000 IU/kg rhEPO, and Group III and Group IV received a single dose of i.p. 16 mg/kg cisplatin injection. In Group IV, 2000 IU/kg rhEPO was also injected intraperitoneally two times: 24 hours before and 30 minutes after i.p. 16 mg/kg cisplatin injection. DPOAEs and ABR measurements were repeated 72 hours following cisplatin administration, and the animals were sacrificed. The cochleae of animals were evaluated histopathologically by light microscopy, and percentage of apoptotic cells in the spiral ganglion was then determined by immunofluorescence analysis. RESULTS:Post-treatment auditory assessment revealed significant ABR threshold elevations at click and 6 kHz and 8 kHz frequencies in Group III compared to Groups I and II (p<0.05). In Group III, 8 kHz DPOAEs were also significantly deteriorated compared to Groups I and II (p<0.05). In Group IV, the ABR thresholds and DPOAEs were protected at click and 6 kHz; there was no statistically significant difference between Group IV and Group I at those frequencies. Concomitant administration of rhEPO and cisplatin significantly reduced apoptosis and cell damage. The apoptotic cell percentage of spiral ganglions in Group IV was significantly less than in Group III (p=0.01). CONCLUSION:Our results showed that i.p. application of rhEPO inhibited apoptosis and prevented cisplatin-induced ototoxicity in rats.

show abstract

Effect of erythropoietin therapy on the progression of cisplatin induced renal injury in rats

Cited by 31 publications

References 35 publications

Dietary inclusion of sorghum (Sorghum bicolour) straw dye protects against cisplatin-induced nephrotoxicity and oxidative stress in rats

Dietary inclusion of sorghum (Sorghum bicolour) straw dye protects against cisplatin-induced nephrotoxicity and oxidative stress in rats

Effects of fennel essential oil on cisplatin-induced nephrotoxicity in ovariectomized rats

The Protective Effect of Recombinant Human Erythropoietin against Cisplatin-Induced Ototoxicity

Contact Info

Product

Resources

About