Effect of Esophageal Acid and Prophylactic Rabeprazole on Performance in Runners

Rodriguez–Stanley, Sheila; Bemben, Debra A.; Zubaidi, Sattar; Redinger, Nancy; Miner, Philip B.

doi:10.1249/01.mss.0000229103.31521.b3

Cited by 7 publications

(6 citation statements)

References 20 publications

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“…In the second study performed in runners with or without retrosternal burning, although provocative esophageal acid perfusion decreased exercise performance, this effect could not be attributed to changes in pulmonary function. None showed change in airway resistance during exercise 12 . These findings are compatible with the existing literature, which does not clearly demonstrate a specific pathophysiological disorder of pulmonary function as a consequence of GERD 8,15,16,22 …”

Section: Discussionsupporting

confidence: 87%

“…They found no statistically significant difference even in the subgroup of patients with abnormal spirometry and esophagitis, which was completely healed, although medical treatment was composed not of proton pump inhibitors but of ranitidine and sucralfate. Rodriguez‐Stanley et al 12 . also found no improvement in exercise performance in runners with retrosternal burning who were treated with rabeprazole 20 mg per day for 12 weeks.…”

Section: Discussionmentioning

confidence: 95%

“…Only few studies have used an exercise test to study the impact of acid gastroesophageal reflux, spontaneous or stimulated on pulmonary function 12–15 . There are no convincing data about the effect of gastroesophageal reflux on exercise performance and on cardiopulmonary function 12,13 . There was no study evaluating the respiratory function using CPET in patients with GERD and extraesophageal symptoms so far.…”

Section: Introductionmentioning

confidence: 99%

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Patients with gastroesophageal reflux disease and respiratory manifestations do not present lung function disorders during cardiopulmonary exercise test

Giannikoulis

Karkoulias

Thomopoulos³

et al. 2010

Diseases of the Esophagus

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Gastroesophageal reflux disease (GERD) has been associated with a variety of pulmonary manifestations, but it is unclear if gastroesophageal reflux causes any abnormality in pulmonary function. Cardiopulmonary exercise test (CPET) is a specialized method that is used to evaluate respiratory function during exercise. The aim of this study was to reveal any abnormality of pulmonary function in patients with GERD and respiratory symptoms. We evaluated 34 patients with GERD (24 men and 10 women, aged 21-63) and extraesophageal respiratory symptoms (wheezing and/or cough) before therapy and after a 12-week treatment with double dose of omeprazole. No patient presented abnormal spirometry. CPET was performed in all the patients at baseline and after completion of the 12-week treatment. CPET parameters including VO(2) rest, VO(2) max, VCO(2) rest, VCO(2) max, O(2)-puls rest, O(2)-puls max, HR (heart rate) rest, HRmax, PETCO(2) rest, PETCO(2) max, and VE/VCO(2) slope were recorded pretreatment and posttreatment. Twenty-four patients (70.6%) had esophagitis (grade A-D), 16 patients had hiatal hernia (47.1%), and 13 patients (38.2%) tested positive for Helicobacter pylori. All of the patients completed the CPET. No one presented shortness of breath or respiratory symptoms. CPET parameters were within normal limits in all of the patients. Twenty-eight patients were reevaluated. No improvement in any CPET parameter posttreatment was observed despite remission of esophageal and extraesophageal respiratory symptoms in all patients. No statistically significant difference was observed pretreatment and posttreatment between the patients older and younger than 40 years, smokers and nonsmokers, Hp(+) and Hp(-) patients, and those with and without hiatal hernia and esophagitis. The patients with GERD and respiratory manifestations and normal spirometry present no pulmonary dysfunction during CPET. No alterations in CPET values posttreatment or differences in CPET values according to age, smoking, Hp status, presence of esophagitis, or hiatal hernia were observed.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

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Patients with gastroesophageal reflux disease and respiratory manifestations do not present lung function disorders during cardiopulmonary exercise test

Giannikoulis

Karkoulias

Thomopoulos³

et al. 2010

Diseases of the Esophagus

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show abstract

“…A trial of antacids or H2-receptor antagonists for intermittent exercise or proton pump inhibitors (PPIs) for regular exercise-associated refl ux symptoms is reasonable. Th e eff ectiveness of PPIs to improve symptoms and performance during exercise, however, was not clearly demonstrated in prior studies ( 7,8 ). Application of the mechanistic details provided by Herregods et al suggests that commonsense lifestyle modifi cations have rationale.…”

mentioning

confidence: 96%

Editorial: Reflux While Running: Something to Belch About

Carlson

Hirano

2016

American Journal of Gastroenterology

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Running is the most popular form of exercise in the United States. Gastroesophageal reflux (GER) is common during exercise and may affect performance. Previous studies have focused on increased intra-abdominal pressure as a major determinant of acid reflux during physical exertion. In this issue, Herregods et al. examined the mechanisms of GER in healthy volunteers using simultaneous high-resolution manometry and pH impedance testing performed while running. Novel observations afforded by the utilization of state-of-the-art technology include the importance of transient lower esophageal sphincter relaxation ("belch reflex") and transient formation of hiatal hernia during exercise. The findings are provocative and lend credence to commonsense strategies to minimize the consequences of belching in runners.

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“…A recent study in human runners addressed the effect of GERD and treatment with antisecretory agents on poor performance (Rodriguez-Stanley et al 2006). In that study, runners with frequent GERD had a significantly decreased time to exhaustion compared to runners without reflux.…”

mentioning

confidence: 99%

Poor performance: Can heartburn slow a horse?

Andrews

2008

Equine Veterinary Education

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Effect of Esophageal Acid and Prophylactic Rabeprazole on Performance in Runners

Abstract: Esophageal acid perfusion decreased performance. In runners with heartburn, suppression of endogenous acid secretion did not improve exercise performance. Changes in cardiopulmonary function do not explain the decreased exercise performance during acid perfusion.

Cited by 7 publications

References 20 publications

Patients with gastroesophageal reflux disease and respiratory manifestations do not present lung function disorders during cardiopulmonary exercise test

Patients with gastroesophageal reflux disease and respiratory manifestations do not present lung function disorders during cardiopulmonary exercise test

Editorial: Reflux While Running: Something to Belch About

Poor performance: Can heartburn slow a horse?

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