Effect of esophagus distention on urinary bladder function in rats

Can. J. Physiol. Pharmacol.

2019

Self Cite

The coexistence of different visceral pathologies in patients suffering from irritable bowel syndrome, interstitial cystitis, and other pathologies, necessitates the study of these pathologies under complicated conditions. In the present study, cystometry recordings were used to investigate the effect of distal esophageal chemical irritation on the urinary bladder interaction with distal colon distention, distal esophageal distention, and electrical stimulation of abdominal branches of vagus nerve. Distal esophageal chemical irritation significantly decreased the intercontraction time via decreasing the voiding time. Also, distal esophageal chemical irritation significantly decreased the pressure amplitude by decreasing the maximum pressure. Following distal esophageal chemical irritation, distal esophageal distention was able to significantly decrease the intercontraction time by decreasing the storage time. However, 3 mL distal colon distention significantly increased the intercontraction time by increasing the storage time. On the other hand, following distal esophageal chemical irritation, electrical stimulation of abdominal branches of vagus nerve did not have any significant effect on intercontraction time. However, electrical stimulation of abdominal branches of vagus nerve significantly increased the pressure amplitude by increasing the maximum pressure. The results of this study demonstrate that urinary bladder function and interaction of bladder with other viscera can be affected by chemical irritation of distal esophagus.

Section: R a F Tsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 87%

Effect of distal esophageal irritation on the changes of cystometry parameters to esophagus and colon distentions in rats

Can. J. Physiol. Pharmacol.

2019

Self Cite

“…For example, urinary bladder function increased by esophageal distention and vagal nerve stimulation. These effects were proved to be through vagal afferents [13]. Interaction between bladder and esophagus is also due to convergence of visceral inputs into the central nervous system centers.…”

Section: Introductionmentioning

confidence: 98%

Cervical vagotomy increased the distal colon distention to urinary bladder inhibitory reflex in male rats

2015

Clin Auton Res

Self Cite

“…For example, colon inflammation in rats was shown to increase urinary bladder frequency ( 2 ). In addition, esophagus distention and electrical stimulation of vagus nerve, in rats, increased urinary bladder contraction frequency ( 3 ). In humans, patients with irritable bowel syndrome showed symptoms of urinary bladder dysfunction, such as, an increase in urination frequency, as well as an increase in residual volume ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

The influence of distal colon irritation on the changes of cystometry parameters to esophagus and colon distentions

2016

Int. braz j urol.

Self Cite

The co-occurrence of multiple pathologies in the pelvic viscera in the same patient, such as, irritable bowel syndrome and interstitial cystitis, indicates the complexity of viscero-visceral interactions and the necessity to study these interactions under multiple pathological conditions. In the present study, the effect of distal colon irritation (DCI) on the urinary bladder interaction with distal esophagus distention (DED), distal colon distention (DCD), and electrical stimulation of the abdominal branches of vagus nerve (abd-vagus) were investigated using cystometry parameters. The DCI significantly decreased the intercontraction time (ICT) by decreasing the storage time (ST); nonetheless, DED and Abd-vagus were still able to significantly decrease the ICT and ST following DCI. However, DCD had no effect on ICT following the DCI. The DCI, also, significantly decreased the Intravesical pressure amplitude (P-amplitude) by increasing the resting pressure (RP). Although DED has no effect on the P-amplitude, both in the intact and the irritated animals, the abd-vagus significantly increased the P-amplitude following DCI by increasing the maximum pressure (MP). In the contrary, 3mL DCD significantly increased the P-amplitude by increasing the MP and lost that effect following the DCI. Concerning the pressure threshold (PT), none of the stimuli had any significant changes in the intact animals. However, DCI significantly decreased the PT, also, the abd-vagus and 3mL DCD significantly decreased the PT. The results of this study indicate that chemical irritation of colon complicates the effects of mechanical irritation of esophagus and colon on urinary bladder function.