Effect of essential oil of Syringa pinnatifolia Hemsl. var. alashanensis on ischemia of myocardium, hypoxia and platelet aggregation

Yan, Yan; Wuliji, O; Zhao, Xiaojing; Ye, Xiaochuan; Zhang, Cong; Hao, Jianjun; He, Junbing; Zhu, Xu; Xu, Huibi; Yang, Xiangliang

doi:10.1016/j.jep.2010.06.027

Cited by 53 publications

(36 citation statements)

References 32 publications

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“…In this study, also, the ST segment of ECG showed significant changes (depression and elevation) after compared with before cold simulation. ST changes on ECG have been reported to indicate myocardial ischemia in rats as well as humans, 19) and the results of this study suggest that cold stimulation is likely to have induced myocardial ischemia in diabetic rats.…”

supporting

confidence: 62%

Cardiac Sympathetic Activity Assessed by Heart Rate Variability Indicates Myocardial Ischemia on Cold Exposure in Diabetes

et al. 2012

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IntroductIonThe world's diabetic population in 2010 was 285 million, and has recently been increasing. Diabetes is known to markedly raise morbidity and mortality rates from cardiovascular disease, 1) the risk factors of which include obesity, smoking, stress, old age, and cold stimulation. 2,3) The measurement of the coronary blood flow by cardiac catheterization and positron emission tomography (PET) has suggested that cold stimulation induces contraction of the cardiac microvasculature by sympathetic nerve activity, but the induction of coronary vasoconstriction by cold exposure has not been directly confirmed. 4,5) We experimentally measured heart rate variability (HRV) by plain electrocardiogram (ECG) as an index of the cardiac sympathetic nerve function, and evaluated whether or not it allows the prediction of the risk of myocardial ischemia on cold exposure, which may be exacerbated in diabetes. 6) Methods Preparation of diabetic rats and evaluation of agingDiabetes was induced in male Wistar rats (5 weeks old) by administering streptozotocin (STZ, 65 mg/kg once, i.p.). 7) The animals that showed a blood glucose level of 400 mg/dl or higher 20 weeks after STZ administration were regarded as a Diabetes Mellitus (DM) group 8) and compared with controls cared for over the same period without STZ administration (n = 6 for each group).This experiment was carried out with approval by the Institutional Review Board of the Laboratory Animal Resource Center, University of Tsukuba, Japan. Measurement of heart rate variability (HRV) is a non-invasive technique that can be used to investigate functioning of the autonomic nervous system, especially the balance between sympathetic and vagal activities. It is reported that dilatation of coronary microcirculation by augmentation of sympathetic nerve activity (SNA) caused by cold exposure was impaired in diabetes. The question of whether or not SNA in HRV could respond to coronary ischemia was evaluated by cold exposure in diabetic rats. It was found that diabetes with weight loss significantly increased SNA both in baseline and cold exposure, compared with control. A correspondence was also found with coronary ischemia. It can be concluded that measurement of HRV may provide useful information regarding the coronary risk of cold exposure in diabetes. (*English translation of J Jpn Coll Angiol 2012; 52: 295-301) Cardiac Sympathetic Activity Assessed by Heart Rate Variability Indicates Myocardial Ischemia on Cold Exposure in Diabetes

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supporting

confidence: 62%

Cardiac Sympathetic Activity Assessed by Heart Rate Variability Indicates Myocardial Ischemia on Cold Exposure in Diabetes

et al. 2012

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“…In the ischemic myocardium, the generation and accumulation of reactive oxygen species (ROS), such as superoxide anion, hydroxyl radicals ( • OH) and other reactive species induced by oxidative stress can overwhelm the intrinsic antioxidants and bring about a damage to cardiac cells, as a result of peroxidation of lipids, proteins, carbohydrates and DNA Foadoddini et al, 2011). This kind of ROS-induced cardiac cell injury plays an important role in the pathogenesis of myocardial ischemia injury and myocardial infarction (Yan et al, 2010). Accordingly, successful antioxidant interventions targeted to cleave ROS, which to date has attracted intensive interests from investigators offer insights into delaying or preventing onset of IHD (Zhu et al, 2004;Zhong et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Cardioprotective effects of saponins from Panax japonicus on acute myocardial ischemia against oxidative stress-triggered damage and cardiac cell death in rats

He¹,

Xu²,

Xu³

et al. 2012

Journal of Ethnopharmacology

101

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“…The global optimization was started with parameters of a population of 100 randomly positioned individuals. The maximum number of energy evaluations was increased to 2.5×10 7 and the maximum number of generations in the Lamarckian genetic algorithm was increased to 2.7×10 5 . The Solis and Wets local search was performed with a maximum number of 3,000.…”

Section: Molecular Dockingmentioning

confidence: 99%

“…Traditional medicines attract much interest due to their ability to inhibit inflammation, platelet aggregation, thrombosis, ischemia of myocardium, cancer, etc. [1][2][3][4][5][6] P-selectin (sP-selectin). The increase of sP-selectin levels in blood is one of the downstream events of in vivo platelet aggregation and thrombosis, and, consequently, the downregulation of sP-selectin is considered a possible target of both anti-inflammatory and antithrombotic agents.…”

Section: Introductionmentioning

confidence: 99%

Aqueous extract of Rabdosia rubescens leaves: forming nanoparticles, targeting P-selectin, and inhibiting thrombosis

Wang¹,

Tang²,

Zhu³

et al. 2015

IJN

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The hot water extract of Rabdosia rubescens was traditionally used as an antithrombotic medicine. To explore its antithrombotic utility and mechanism, we carried out a series of in vitro and in vivo assays in this study. In vitro platelet aggregation assay showed that the half maximal inhibitory concentration values of aqueous extract of R. rubescens leaves (AERL) inhibiting platelet aggregation induced by thrombin, arachidonic acid, adenosine diphosphate, and platelet-activating factor ranged from 0.12 mg/mL to 1.43 mg/mL. The minimal effective oral dose of AERL inhibiting the rats from forming thrombus was 25 mg/kg. Both in vitro and in vivo actions were correlated with AERL concentration-dependently inhibiting sP-selectin release. In water, AERL formed nanoparticles, and their size depended on the concentration. Docking the five nucleotides, 21 phenolic acids, and four diterpenoids identified by high-performance liquid chromatography–photodiode array detector/(−)electrospray ionization-tandem mass spectrometry analysis into the active site of P-selectin, rosmarinic acid was predicted to be the antithrombotic ingredient of AERL. In flow cytometry analysis, 1 μM of rosmarinic acid effectively inhibited sP-selectin release in arachidonic acid-activated platelets. In a rat model, 5 mg/kg of oral rosmarinic acid effectively inhibited thrombosis.

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Effect of essential oil of Syringa pinnatifolia Hemsl. var. alashanensis on ischemia of myocardium, hypoxia and platelet aggregation

Cited by 53 publications

References 32 publications

Cardiac Sympathetic Activity Assessed by Heart Rate Variability Indicates Myocardial Ischemia on Cold Exposure in Diabetes

Cardiac Sympathetic Activity Assessed by Heart Rate Variability Indicates Myocardial Ischemia on Cold Exposure in Diabetes

Cardioprotective effects of saponins from Panax japonicus on acute myocardial ischemia against oxidative stress-triggered damage and cardiac cell death in rats

Aqueous extract of Rabdosia rubescens leaves: forming nanoparticles, targeting P-selectin, and inhibiting thrombosis

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