Effect of essential oil of onion and garlic on experimental atherosclerosis in rabbits

Bordia, A; Verma, Surendra Kumar; Vyas, Apurva; Khabya, B.L.; Rathore, Anita; N, Bhu; Bedi, H.K.

doi:10.1016/0021-9150(77)90092-2

Cited by 148 publications

(83 citation statements)

References 14 publications

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“…This imbalance can cause the excessive concentration of free radicals in body, leading to the oxidative damage of cell membranes, lipids, nucleic acids and proteins, which results in the cell structure and function destruction and occurrence and development of diseases (Blokhina et al, 2003). Garlic has the antibacterial (Farbman et al, 1993), antiviral (Tsai et al, 1985), anti-inflammatory (Kim et al, 2013b), insecticidal (Yang et al, 2009), blood lipid regulating (Bordia et al, 1998), blood glucose decreasing (Bordia et al, 1998), detoxification (Sheen et al, 1996), atherosclerosis preventing (Bordia et al, 1977) and immunity improving (Qiu et al, 2014) functions. It is reported that, the pharmacological effects of garlic are closely related to its antioxidant properties (El-Din et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

In vitro and in vivo antioxidant activities of polyphenol extracted from black garlic

Wang

Sun

2017

Food Sci. Technol

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This study investigated the in vitro and in vivo antioxidant activities of polyphenol extracted from black garlic. Black garlic polyphenol (BGP) was extracted from black garlic. The in vitro antioxidant activities of BGP were determined using DPPH·, OH and O 2-radical scavenging assays. The in vivo antioxidant activities were determined by detecting the malondialdehyde (MDA) content and superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities in mice. Results showed that, the DPPH· radical inhibition rate of 200 and 250 μg/mL BGP was equivalent with Vc (P > 0.05). With concentration of 400 and 500 μg/mL, the OH radical inhibition rate of BGP was slightly lower than Vc (P > 0.05). The O 2-radical inhibition rates of 200, 400, 600, 800 and 1000 μg/mL BGP were significantly lower than Vc (P < 0.05). In the groups treated with BGP with suitable dose, the serum MDA content was significantly decreased compared with model group (P < 0.05), and the serum SOD and GSH-Px activities were significantly increased (P < 0.05). BGP has obvious DPPH· and ·OH radical scavenging activities, and can significantly decrease the serum MDA content in mice with oxidative damage, and increase the serum SOD and GSH-Px activities.

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Section: Discussionmentioning

confidence: 99%

In vitro and in vivo antioxidant activities of polyphenol extracted from black garlic

Wang

Sun

2017

Food Sci. Technol

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“…These lesions only begin to stabilize weeks after the removal of cholesterol from the diet and as the hypercholesterolemia resolves (1,11,26,29,48). Thus, if an intervention is imposed immediately after the withdrawal of cholesterol from the diet, as has been done in previous studies of regression (5,8,10,44,45), any effects observed will reflect an inhibition of plaque progression and not an effect on plaque regression.The objective of the present study was to 1) identify a suitable dietary regimen in rabbits that showed clear evidence of plaque growth stabilization, 2) determine the ability of dietary flaxseed to induce or accelerate atherosclerotic plaque regression, and 3) discern whether flaxseed supplementation can reverse any cholesterol-induced vascular contractile abnormalities. It was hypothesized that flaxseed would accelerate the regression of atherosclerotic plaques and improve vascular abnormalities caused by cholesterol supplementation.…”

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confidence: 94%

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confidence: 94%

“…Moreover, milled flaxseed has proven to be cardioprotective and antiatherogenic in animal models (7,22,23,44) as well as in clinical settings (50). However, although flaxseed can diminish the progression of atherosclerotic plaques, it is unclear if dietary supplementation with flaxseed can regress established atherosclerotic plaques.Although many studies have used nutritional interventions to induce plaque regression (5,8,10,45), these studies have all prematurely initiated their interventions before there was clear evidence of the cessation of plaque growth. If a rabbit is supplemented with dietary cholesterol followed by the withdrawal of cholesterol from the diet, atherosclerotic lesions actively continue to progress.…”

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confidence: 99%

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Effects of dietary flaxseed on atherosclerotic plaque regression

Francis

Deniset

Austria

et al. 2013

American Journal of Physiology-Heart and Circulatory Physiology

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Francis AA, Deniset JF, Austria JA, LaValleé RK, Maddaford GG, Hedley TE, Dibrov E, Pierce GN. Effects of dietary flaxseed on atherosclerotic plaque regression. Am J Physiol Heart Circ Physiol 304: H1743-H1751, 2013. First published April 12, 2013 doi:10.1152/ajpheart.00606.2012.-Dietary flaxseed can retard the progression of atherosclerotic plaques. However, it remains unclear whether these antiatherogenic effects extend to plaque regression. In the present study, the therapeutic potential of dietary flaxseed on atherosclerotic plaque regression and vascular contractile function was evaluated using a novel rabbit model. Rabbits were randomly assigned to receive either a regular diet for 12 wk (group I) or a 1% cholesterol-supplemented diet for 4 wk followed by a regular diet for 8 wk (group II). The remaining experimental animals were treated as in group II but were fed for an additional 14 wk with either a regular diet (group III) or a 10% flaxseed-supplemented diet (group IV). Animals in group II showed clear evidence of plaque growth stabilization. Their vessels also exhibited significantly lower norepinephrine-induced contraction and an impaired relaxation response to acetylcholine compared with animals in group I. Dietary flaxseed supplementation resulted in a significant Ϸ40% reduction in plaque formation (P ϭ 0.033). Animals in both groups II and III displayed improved contraction and endothelium-dependent vessel relaxation. Dietary flaxseed is a valuable strategy to accelerate the regression of atherosclerotic plaques; however, flaxseed intervention did not demonstrate a clear beneficial effect on the vessel contractile response and endothelium-dependent vasorelaxation. atherosclerosis; flaxseed; heart disease; regression; vascular contractile function CARDIOVASCULAR DISEASE (CVD) is currently the leading cause of mortality worldwide. Its prevalence continues to increase despite improved treatments for atherosclerosis and will reach epidemic proportions within a decade due to the escalating predominance of sedentary, unhealthy lifestyles (32, 51, 52). Atherosclerosis is orchestrated by a complex array of molecular and cellular events commencing after endothelial injury. The resultant plaques may continue to progress, ultimately causing acute events such as myocardial infarction and stroke (23,32). Recently, it has been shown that atherosclerotic plaques are highly dynamic and that their progression can be slowed, stopped, and even reversed by drug intervention (6,18,43). For example, aggressive risk modification with statin drug therapy can remove lipids and necrotic material, restore endothelial function and viability, and prevent vascular smooth muscle cell proliferation and phenotype reversal, three processes involved in atherosclerotic plaque formation (18, 43).Akin to pharmaceuticals, functional foods can also be used to prevent and treat CVD. A functional food has a similar appearance to or may be a conventional food and may be consumed as part of a normal diet to have physiological benefits and/...

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“…On the other hand, glucagons, catecholamine and other hormones enhance lipolysis. The marked hyperlipidemia that characterizes the diabetic state may, therefore, be regarded because of the unregulated actions of lipolytic hormones on the fat depots 35 . A. sativum and glibenclamide both caused a significant decrease in the plasma levels of TC, TG, PL and FFA in alloxan-induced hyperglycemia.…”

Section: Discussionmentioning

confidence: 99%

Untitled

2016

IJPSR

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ABSTRACT:Allium sativum (A. sativum), commonly known as garlic, is a species in the onion genus, Allium. The hypolipidemic activity of A. Sativum (Family: Amaryllidaceae) extract have been studied in alloxan-induced diabetic rats. In this model oral administration of extract (500mg/kg bw., p.o.) for 15 days in diabeticdyslipidemic rats exerted significant lipid lowering effect as assessed by the reversal of serum levels of total cholesterol, phospholipids, triglyceride, free fatty acids, protein and lipid peroxide. The decrease of lipids and apoprotein levels of Very Low Density Lipoprotein and Low Density Lipoprotein were followed by stimulation of plasma post-heparin lipolytic activity as well as lecithin cholesterol acyltransferase, hepatic superoxide dismutase, catalase, triglyceride lipase and lipoprotein lipase activities with increase in reduced glutathione. Lipid and apoprotein level of High Density Lipoprotein were also recovered partially on treatment with A. sativum extract. The results of the present study demonstrated antidyslipidemic and antioxidant activities in A. sativum extract which could be used in prevention of diabetic dyslipidemia and related complications. The hypolipidemic activity of A. sativum was compared with a standard drug glibenclamide (600 µg/kg b.w./day, p.o.).

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Effect of essential oil of onion and garlic on experimental atherosclerosis in rabbits

Cited by 148 publications

References 14 publications

In vitro and in vivo antioxidant activities of polyphenol extracted from black garlic

In vitro and in vivo antioxidant activities of polyphenol extracted from black garlic

Effects of dietary flaxseed on atherosclerotic plaque regression

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