Effect of Estradiol and Testosterone on the Fatty Acids of Plasma Cholesteryl Esters and Phospholipids in the Castrated Rat

Lyman, R. Lee; Shannon, Angela; Ostwald, Rosemarie; Miljanich, P.

doi:10.1139/o64-044

Cited by 33 publications

(7 citation statements)

References 28 publications

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“…22:6) (21). In the Serum lipids and fotw m i d composition of serum lecithin 5 animal, in vivo and in vitro studies indicate that pathway I1 is more active in the female (17, 26) as well as during estrogen administration (18). Studies during the menstrual cycle in young women suggest that this influence by estrogens on pathway I1 is applicable also in man (10).…”

Section: Discussionmentioning

confidence: 99%

Serum Lipids and Fatty Acid Composition of Serum Lecithin in the Non‐Pregnant State in Patients with Previous Cholestasis of Pregnancy

Samsioe¹

1976

Acta Obstet Gynecol Scand

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Serum lipids and fatty acid composition of serum lecithin were studied 8-21 months after delivery in 20 non-pregnant women who during their latest pregnancy had presented signs of CP. These women were compared with normal non-pregnant women (n=18) and with patients with cholestasis of pregnancy (CP) (n=28). In the non-pregnant state women with previous cholestasis of pregnancy (CP) showed in serum lecithin a low relative content of palmitic (16:0) and linoleic (18:2) acids and a high portion of stearic acid (18:0). These findings indicate as a basic defect in CP, a reduction in liver lecithin synthesis via pathway I (Kennedy's pathway) in favour of an increased pathway II (Greenberg's pathway). These data further support the hypothesis of increased estrogen activity as an etiological factor in CP. The basic influence by pregnancy on serum lipids and serum lecithin fatty acid composition was the same in women with CP as in women with a normal pregnancy.

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Section: Discussionmentioning

confidence: 99%

Serum Lipids and Fatty Acid Composition of Serum Lecithin in the Non‐Pregnant State in Patients with Previous Cholestasis of Pregnancy

Samsioe¹

1976

Acta Obstet Gynecol Scand

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“…The relative decrease of sphingomyelin is in accordance with the findings in pregnancy, but an absolute increase of sphingomyelin was found by Jensen only in some of the cases. Lyman et al (40) found no effect on the phospholipid pattern in castrated rats which were treated with small physiological doses of estradiol; but the effect of large doses comparable to the amounts produced during pregnancy was not studied. In a recent paper (27) the effect of small doses of conjugated equine estrogens on the serum phospholipids in post-menopausal women was reported.…”

Section: Discussionmentioning

confidence: 99%

Plasma Lipid Fractions, Including Individual Phospholipids, at Various Stages of Pregnancy

Svanborg¹,

Vikrot²

1965

Journal of Internal Medicine

102

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“…Depending upon the sex of the animal, chronic ethanol ingestion affects the oxidation of certain mitochondrial substrates differently (1,2)o These differences have been related to the male sex hormone, testosterone (2). In studies not related to ethanol ingestion, estradiol and testosterone have been shown to affect the biosynthesis of phosphatidylcholine (PC) (3,4). Other researchers (5-7) have reported sex differences in total liver lipid composition as well as in liver lipid metabolism (4,(8)(9)(10)(11), and a fractionation of liver PC has shown sex differences in certain molecular species of PC (12).…”

Section: Introductionmentioning

confidence: 99%

Effects of ethanol ingestion and dietary fat levels on mitochondrial lipids in male and female rats

Thompson

Reitz

1978

Lipids

156

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The effects of sex, dietary fat levels, and ethanol ingestion on rat liver mitochondrial lipids have been studied. Two groups of male animals were fed either a low‐fat diet for about 76 days or a high‐fat diet for about 52 days, and two groups of female animals were fed the same low‐fat diet for about 50 days or the high‐fat diet for about 37 days. Ethanol was substituted isocalorically for carbohydrate and amounted to 36% of total calories. The total as well as individual concentrations of fatty acids, phospholipids, and neutral lipids were determined in all eight groups of animals. Variable changes were observed in the total fatty acid composition of mitochondria from each of the four groups of animals. After ethanol ingestion, there was a decrease in arachidonate/linoleate ratio in males, while no change was observed in females. Increasing the fat content of the diet decreased this ratio in both controls and experimentals, but it did not alter the effects of ethanol on either sex. Presumably, this was due to the fact that corn oil was the only source of lipid. After ethanol ingestion, the total fatty acid concentration increased in all groups of animals except the males fed the low‐fat diet. A decrease was observed in this group. The same pattern of change was reflected in changes in total phospholipid concentrations. In each case, the majority of the concentration change in total phospholipid could be accounted for by changes in phosphatidylcholine (PC). Measurement of choline oxidase (C.O.) showed that ethanol ingestion increased C.O. activity only in the low‐fat group of males. No change was observed in the other three groups. Chronic ethanol ingestion is known to increase the methylation of phosphatidylethanolamine (PE); therefore, in order to decrease PC, the increase in C.O. in the low‐fat males must have been of sufficient magnitude to offset the increase in PE methylation. Increasing the fat content of the diet offset the effect of ethanol on C.O. in males. Neither ethanol nor fat exerted much effect on C.O. in females. These results emphasize the importance of dietary levels of fat as well as sex in the study of liver mitochondria structure and function in relation to ethanol metabolism.

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Effect of Estradiol and Testosterone on the Fatty Acids of Plasma Cholesteryl Esters and Phospholipids in the Castrated Rat

Cited by 33 publications

References 28 publications

Serum Lipids and Fatty Acid Composition of Serum Lecithin in the Non‐Pregnant State in Patients with Previous Cholestasis of Pregnancy

Serum Lipids and Fatty Acid Composition of Serum Lecithin in the Non‐Pregnant State in Patients with Previous Cholestasis of Pregnancy

Plasma Lipid Fractions, Including Individual Phospholipids, at Various Stages of Pregnancy

Effects of ethanol ingestion and dietary fat levels on mitochondrial lipids in male and female rats

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