Effect of estradiol dipropionate and testosterone propionate on the glycogen, lipid, and water contents of liver, muscle, and gonad of male and female (vitellogenic and nonvitellogenic) Singi fish (Heteropneustes fossilis bloch)

Dasmahapatra, Asok K.; Medda, A

doi:10.1016/0016-6480(82)90183-6

Cited by 22 publications

(14 citation statements)

References 28 publications

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“…The latter was confirmed in the present study: the liver glycogen content of T-treated fish was increased by 46.5%. This finding was in accordance with the findings in red grouper (Ng et al 1984) and singi fish (Dasmahapatra and Medda 1982).…”

Section: Discussionsupporting

confidence: 82%

“…E2 caused an increase in serum concentrations of total protein, albumin, globulin and the yolk precursor protein, vitellogenin. It is well established that E2 induces vitellogenin production in many teleost species including the flounder (Emmersen and Petersen 1976;Petersen et al 1983), rainbow trout (Haux and Norberg 1985), brook trout (Whiting and Wiggs 1978), red grouper (Tam et al 1983), channel catfish (Bradley and Grizzle 1989) and singi fish (Medda et al 1980;Dasmahapatra and Medda 1982). The present work showed that E2 could also induce vitellogenin synthesis in immature red sea bream.…”

Section: Discussionsupporting

confidence: 56%

“…The present study showed that E2, at a dose of 3 ppm, had no effect on serum glucose concentration in the red sea bream. Furthermore, the usual depletion of hepatic glycogen after E2 treatment (Haux and Norberg 1985;Korsgaard and Petersen 1979;Dasmahapatra and Medda 1982;Petersen et al 1983;Whiting and Wiggs 1978) did not occur. Muscle glycogen content and the activities of some important enzymes in the pathways of carbohydrate metabolism, such as GP, G6Pase and FDPase were also unaffected by E2 treatment.…”

Section: Discussionmentioning

confidence: 92%

“…Most investigations on the effects of sex steroids in teleosts are usually confined to studying only one aspect of a vast array of related phenomena such as growth (Malison et al 1988;Ali and Rao 1989;Simone 1990), digestion and food utilization (Ince et al 1982), gut transport (Habibi et al 1983), hepatic enzyme activities (Peter and Oommen 1989), vitellogenesis (Bradley and Grizzle 1989), and shifts in body composition (Dasmahapatra and Medda 1982;Haux and Norberg 1985). To the best of the authors' knowledge, no study has yet attempted to study and correlate the effects of male and female sex steroids on growth, appetite, digestion, and associated metabolic changes in a single species.…”

Section: Introductionmentioning

confidence: 99%

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Influence of oral administration of estradiol-17? and testosterone on growth, digestion, food conversion and metabolism in the underyearling red sea bream, Chrysophrys major

Woo

Chung

1993

Fish Physiol Biochem

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Estradiol-17β (E2) administered in the diet to the red sea bream Chrysophrys major did not affect appetite, food conversion efficiency, protein efficiency ratio and specific growth rate. Serum concentrations of total protein, albumin, globulin, vitellogenin, α-amino acids, total lipid, free fatty acids, cholesterol and calcium were elevated. The hepatosomatic index was also increased. Activities of hepatic enzymes including lactate dehydrogenase, isocitrate dehydrogenase and glutamate-pyruvate transaminase were higher than found in untreated control fish. Intestinal activity of leucine aminopeptidase was augmented. However, there were no changes in muscle water, protein, lipid and glycogen content. In contrast, testosterone (T) given by the same route increased appetite, food conversion efficiency, protein efficiency ratio and specific growth rate. There were no alterations in serum protein and calcium concentrations but serum glucose, ammonia and triglyceride levels were elevated. Hepatic glycogen content was increased. The activities of hepatic fructose- 1,6-diphosphatase, glucose-6-phosphatase and glycogen synthetase and intestinal activities of alkaline phosphatase and τ-glutamyltransferase were higher than noted on control fish. The results reveal that estradiol-17β and testosterone exerted different metabolic effects in the red sea bream and they suggest that testosterone exerts its anabolic actions by increasing appetite, food conversion efficiency and activities of digestive enzymes.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionsupporting

confidence: 56%

Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

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Influence of oral administration of estradiol-17? and testosterone on growth, digestion, food conversion and metabolism in the underyearling red sea bream, Chrysophrys major

Woo

Chung

1993

Fish Physiol Biochem

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“…Previous studies have shown that exposure to estrogens produces a variety of changes in the biochemistry of the liver in fishes (Cakmak et al 2006;Dasmahapatra and Medda 1982;De Vlaming et al 1977a, b;Ekman et al 2008;Haux and Norberg 1985;Khanna and Singh 1983;Korsgaard 1990; Korsgaard and Petersen 1979;SangiaoAlvarellos et al 2005;Sehgal and Goswami 2001;Sharpe and MacLatchy 2007;Whiting and Wiggs 1978), which are thought to contribute to or reflect the adverse effects observed. These studies have primarily reported changes in carbohydrate and amino acid concentrations in addition to altered enzyme activities.…”

Section: Introductionmentioning

confidence: 96%

Profiling lipid metabolites yields unique information on sex- and time-dependent responses of fathead minnows (Pimephales promelas) exposed to 17α-ethynylestradiol

et al. 2008

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Alterations in hepatic lipid profiles of fathead minnows (FHM) exposed to the synthetic estrogen 17a-ethynylestradiol (EE2) were determined using 1 H-NMR spectroscopy-based metabolite profiling. The exposures were conducted using either 10 ng/l or 100 ng/l EE2 via a continuous flow water delivery system. Livers were collected at 1, 4, and 8 days of the exposure and 8 days after the chemical was removed from the water (i.e. an 8 day depuration). The exposure resulted in a number of sex-specific changes in lipid profiles that were also highly time dependent. Those metabolites most affected by exposure included phosphatidylcholine, diglycerides, triglycerides and cholesterol. In addition, changes in the length and degree of unsaturation of hepatic fatty acids were observed. Lipid profiles in plasma for fish collected on the 4th day of exposure were also analyzed in order to provide further insights into changes observed in hepatic metabolite changes. Using validated partial least-squares discriminant analysis (PLS-DA), the response trajectories of the male liver lipid profiles at both exposure concentrations were compared. This analysis indicated that the males exposed to the low concentration of EE2 (10 ng/l) were largely able to recover from the exposure once the chemical was removed from the water. Conversely, the males exposed to the high concentration (100 ng/l) did not appear to recover from the exposure despite the 8 day depuration.

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Bioaccumulation of organochlorine contaminants and ethoxyresorufin‐o‐deethylase activity in southern California round stingrays (Urobatis halleri) exposed to planar aromatic compounds

Lyons

Lavado

Schlenk

et al. 2014

Enviro Toxic and Chemistry

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While contaminant concentrations have been reported for elasmobranchs around the world, no studies have examined bioaccumulation patterns across male and female age classes. The round stingray (Urobatis halleri) is a local benthic species that forages near areas of high organochlorine contamination and represents a good elasmobranch model. Polychlorinated biphenyls (PCBs), DDT, and chlordanes were measured in juvenile and adult male and female stingrays from areas in southern California, USA (n = 208), and a nearby offshore island, Santa Catalina (n = 34). Both mainland juvenile male and female stingrays showed a significant dilution effect. After maturity, summed contaminant concentrations significantly increased with size for adult males (median 11.1 µg/g lipid wt) and females (5.2 µg/g lipid wt). However, the rate of bioaccumulation was substantially greater in male stingrays than in females, likely a result of the females' ability to offload contaminants to offspring during pregnancy. In addition, males and females showed significant differences in their contaminant profiles, suggesting differential habitat use. Male and female stingrays collected from Santa Catalina Island had significantly lower concentrations (0.51 µg/g and 0.66 µg/g lipid wt, respectively), approximately 5 times less than those of mainland animals. Potential toxicity effects mediated through activation of the aryl hydrocarbon receptor were explored through ethoxyresorufin-O-deethylase (EROD) activity assays. Mainland male stingrays exhibited significantly greater EROD activities than Catalina males (481 pmol/min/mg protein and 55 pmol/min/mg protein, respectively); however, activity levels in female stingrays from both locations were comparable (297 pmol/min/mg protein and 234 pmol/min/mg protein, respectively) and lower than those in mainland males. The results suggest that PCBs and/or other structurally related contaminants may be inducing a biological response in mainland males but not females, possibly the result of a dampening effect of estradiol; however, the exact physiological repercussions of exposure remain to be determined.

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Effect of estradiol dipropionate and testosterone propionate on the glycogen, lipid, and water contents of liver, muscle, and gonad of male and female (vitellogenic and nonvitellogenic) Singi fish (Heteropneustes fossilis bloch)

Cited by 22 publications

References 28 publications

Influence of oral administration of estradiol-17? and testosterone on growth, digestion, food conversion and metabolism in the underyearling red sea bream, Chrysophrys major

Influence of oral administration of estradiol-17? and testosterone on growth, digestion, food conversion and metabolism in the underyearling red sea bream, Chrysophrys major

Profiling lipid metabolites yields unique information on sex- and time-dependent responses of fathead minnows (Pimephales promelas) exposed to 17α-ethynylestradiol

Bioaccumulation of organochlorine contaminants and ethoxyresorufin‐o‐deethylase activity in southern California round stingrays (Urobatis halleri) exposed to planar aromatic compounds

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