Effect of Estrogen onin Vivoandin VitroCollagen Biosynthesis and Maturation in Old and Young Female Guinea Pigs1

Henneman, Dorothy H.

doi:10.1210/endo-83-4-678

Cited by 65 publications

(34 citation statements)

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“…In rat skin, E2 has effects on mitosis and on differentiation of epidermis and sebaceous glands (5). E2 also stimulates the synthesis, maturation, and turnover of collagen in rat (220) and guinea pig skin (221). Furthermore, estrogens have been shown to increase mitotic activity in the epidermis of mice and induce epidermal thickening (222,223).…”

Section: A Effects Of Estrogens On the Skinmentioning

confidence: 99%

The Hair Follicle as an Estrogen Target and Source

et al. 2006

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For many decades, androgens have dominated endocrine research in hair growth control. Androgen metabolism and the androgen receptor currently are the key targets for systemic, pharmacological hair growth control in clinical medicine. However, it has long been known that estrogens also profoundly alter hair follicle growth and cycling by binding to locally expressed high-affinity estrogen receptors (ERs). Besides altering the transcription of genes with estrogen-responsive elements, 17␤-estradiol (E2) also modifies androgen metabolism within distinct subunits of the pilosebaceous unit (i.e., hair follicle and sebaceous gland). The latter displays prominent aromatase activity, the key enzyme for androgen conversion to E2, and is both an estrogen source and target.Here, we chart the recent renaissance of estrogen research in hair research; explain why the hair follicle offers an ideal, clinically relevant test system for studying the role of sex steroids, their receptors, and interactions in neuroectodermal-mesodermal interaction systems in general; and illustrate how it can be exploited to identify novel functions and signaling cross talks of ER-mediated signaling. Emphasizing the long-underestimated complexity and species-, gender-, and site-dependence of E2-induced biological effects on the hair follicle, we explore targets for pharmacological intervention in clinically relevant hair cycle manipulation, ranging from androgenetic alopecia and hirsutism via telogen effluvium to chemotherapy-induced alopecia. While defining major open questions, unsolved clinical challenges, and particularly promising research avenues in this area, we argue that the time has come to pay estrogen-mediated signaling the full attention it deserves in future endocrinological therapy of common hair growth disorders. (Endocrine Reviews 27: 677-706, 2006)

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Section: A Effects Of Estrogens On the Skinmentioning

confidence: 99%

The Hair Follicle as an Estrogen Target and Source

et al. 2006

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“…Further details of extraction and reference to original methodology have been published elsewhere [Henneman, 1968[Henneman, , 1970[Henneman, , 1971. DNA content was measured according to the method of Schneider [1957] in a weak alkali extract of bone as described by Flannagan and Nichols [1962], Two young adult female baboons were biopsied and aliquots of skin and cancellous bone from the iliac crest were obtained.…”

Section: Methodsmentioning

confidence: 99%

“…The results were compared to those obtained from a study of comparable samples obtained from 27 young adult normal human males and females and 15 male rats (CNF-Wistar). The procedures used have been described elsewhere with references to the original techniques [Henneman, 1968[Henneman, & 1970. Table I shows the amount of neutral-salt soluble and acid plus EDTA-soluble collagen in metaphyseal cancellous bone from the tibia.…”

Section: Methodsmentioning

confidence: 99%

Comparative Solubility of Bone and Skin Collagen in Primates Including Man

Henneman¹

1972

J Med Primatol

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Man and the chimpanzee were shown to have less soluble bone collagen than the baboon and rhesus monkey in the tibia, iliac crest, and vertebral body. The DNA content of these three bones was significantly less in man than in the other primates and the rat; the monkey and the baboon had lower values than did the rat. In man, the cell content was approximately the same in the tibia, iliac crest and vertebral body while it was 3-4 times greater in the vertebral body in the monkey and baboon. Soluble collagen in human skin was less than in all other species; all primates had relatively less acid-soluble collagen than the rat. Collagen biosynthesis in vitro in baboon skin and bone was greater than that in man and less than that in the rat. The data suggest significant differences between the primate species in the biosynthesis and turnover of collagen although structural differences cannot be ruled out.

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“…Estrogens have been shown to infl uence skin thickness by stimulating collagen synthesis, maturation and turnover in rats (Smith and Allison 1966) and female guinea pigs (Henneman 1968). In mice, estrogen administration increased hyaluronic acid synthesis by 70% in two weeks (Sobel 1965), leading to increased dermal water content.…”

Section: The Dermismentioning

confidence: 99%

Effect of estrogens on skin aging and the potential role of SERMs

Stevenson

Thornton

2007

CIA

127

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Abstract:In humans, structural and functional changes attributable to aging are more visibly evident in the skin than in any other organ. Estrogens have signifi cant effects on skin physiology and modulate epidermal keratinocytes, dermal fi broblasts and melanocytes, in addition to skin appendages including the hair follicle and the sebaceous gland. Importantly, skin aging can be signifi cantly delayed by the administration of estrogen. This paper reviews the effects of estrogens on skin and the mechanisms by which estrogens can alleviate the changes due to aging that occur in human skin. The relevance of estrogen replacement therapy (HRT) in postmenopausal women and the potential value of selective estrogen receptor modulators (SERMs) as a therapy for diminishing skin aging are also highlighted.

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Effect of Estrogen onin Vivoandin VitroCollagen Biosynthesis and Maturation in Old and Young Female Guinea Pigs¹

Cited by 65 publications

References 0 publications

The Hair Follicle as an Estrogen Target and Source

The Hair Follicle as an Estrogen Target and Source

Comparative Solubility of Bone and Skin Collagen in Primates Including Man

Effect of estrogens on skin aging and the potential role of SERMs

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