Effect of Estrogen on Serum and Tissue Levels of Copper and Zinc

Mehta, Sudha W.; Eikum, Renee’

doi:10.1007/978-1-4613-0537-8_13

Cited by 10 publications

(8 citation statements)

References 16 publications

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“…Although grazing performance was affected by implant, serum constituents were not. Held et al (1988) and Mehta and Eikum (1989) reported that estrogenic compounds increased serum copper, but the increase was at the expense of hepatic copper (Mehta and Eikum, 1989). Others have reported results similar to ours.…”

Section: Discussionsupporting

confidence: 83%

“…Others have reported results similar to ours. Mehta and Eikum (1989) reported similar serum zinc concentrations but lower liver zinc content in rats implanted with estradiol. Elsasser et al (1983) reported increased plasma prolactin as a result of estradiol and zeranol injection in ovariectomized ewes but no change in prolactin in wethers injected with either compound.…”

Section: Discussionmentioning

confidence: 83%

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Implant and copper oxide needles for steers grazing Acremonium coenophialum-infected tall fescue pastures: effects on grazing and subsequent feedlot performance and serum constituents

Coffey

Moyer²,

Lomas³

et al. 1992

Journal of Animal Science

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Moyer, Joseph L.; Lomas, Lyle W.; and Brazle, F.K. (1992) "Effect of supplemental grain sorghum and overseeding with ladino clover on grazing and subsequent feedlot performance of steers early-intensively grazed on acremonium coenophialum-infected tall fescue pastures," Kansas Agricultural Experiment Station Research Reports: Vol. 0: Iss. 1. https://doi.org/10.4148/ 2378-5977.2153 Effect of supplemental grain sorghum and overseeding with ladino clover on grazing and subsequent feedlot performance of steers early-intensively grazed on acremonium coenophialum-infected tall fescue pastures Abstract Eighty mixed breed steers (avg. wt. 560 lb.) were used to evaluate the effect on grazing gain and subsequent feedlot performance of different management options for steers early-intensively grazing Acremonium coenophialuminfected tall fescue pastures. Steers were allotted to pastures of infected fescue pastures or infected fescue overseeded with ladino clover and received no supplement or were offered grain sorghum at .25% of their body weight. Neither supplementation nor overseeding affected grazing or feedlot performance. However, grain supplementation on overseeded pastures reduced subsequent feedlot feed efficiency (P<.10). These management options did not substantially affect grazing or subsequent feedlot performance by steers early-intensively grazing infected fescue pastures. Summary Eighty mixed breed steers (avg. wt. 560 lb.) were used to evaluate the effect on grazing gain and subsequent feedlot performance of different management options for steers early-intensively grazing Acremonium coenophialum-infected tall fescue pastures. Steers were allotted to pastures of infected fescue pastures or infected fescue overseeded with ladino clover and received no supplement or were offered grain sorghum at .25% of their body weight. Neither supplementation nor overseeding affected grazing or feedlot performance. However, grain supplementation on overseeded pastures reduced subsequent feedlot feed efficiency (P<.10). These management options did not substantially affect grazing or subsequent feedlot performance by steers early-intensively grazing infected fescue pastures. (

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 83%

Implant and copper oxide needles for steers grazing Acremonium coenophialum-infected tall fescue pastures: effects on grazing and subsequent feedlot performance and serum constituents

Coffey

Moyer²,

Lomas³

et al. 1992

Journal of Animal Science

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“…Estrogens do increase ceruloplasmin levels in females, but in copper deficiency the incorporation of copper into ceruloplasmin is inhibited, and possibly the levels of estrogen in intact prepubertal females are too low to stimulate ceruloplasmin activity 45,89. Increases in the serum copper and ceruloplasmin levels of female rats and other animals with estrogen treatment are clear, and depend upon the duration of hormonal treatment56, 60,83,92,117,182,183,274,290 The increases occurred at the expense of hepatic copper and were not due to increased intestinal absorption, so prolonged estrogen treatment leads to an alteration in the distribution of copper. Copper is also known to affect the level of norepinephrine and dopamine in brain by synthesis and/or release of neurotransmitters 212.…”

Section: Copper Deficiency In Female Reproduction; Pregnancy and Infamentioning

confidence: 98%

Zinc, copper and selenium in reproduction

1994

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Of the nine biological trace elements, zinc, copper and selenium are important in reproduction in males and females. Zinc content is high in the adult testis, and the prostate has a higher concentration of zinc than any other organ of the body. Zinc deficiency first impairs angiotensin converting enzyme (ACE) activity, and this in turn leads to depletion of testosterone and inhibition of spermatogenesis. Defects in spermatozoa are frequently observed in the zinc-deficient rat. Zinc is thought to help to extend the functional life span of the ejaculated spermatozoa. Zinc deficiency in the female can lead to such problems as impaired synthesis/secretion of (FSH) and (LH), abnormal ovarian development, disruption of the estrous cycle, frequent abortion, a prolonged gestation period, teratogenicity, stillbirths, difficulty in parturition, pre-eclampsia, toxemia and low birth weights of infants. The level of testosterone in the male has been suggested to play a role in the severity of copper deficiency. Copper-deficient female rats are protected against mortality due to copper deficiency, and the protection has been suggested to be provided by estrogens, since estrogens alter the subcellular distribution of copper in the liver and increase plasma copper levels by inducing ceruloplasmin synthesis. The selenium content of male gonads increases during pubertal maturation. Selenium is localized in the mitochondrial capsule protein (MCP) of the midpiece. Maximal incorporation in MCP occurs at steps 7 and 12 of spermatogenesis and uptake decreases by step 15. Selenium deficiency in females results in infertility, abortions and retention of the placenta. The newborns from a selenium-deficient mother suffer from muscular weakness, but the concentration of selenium during pregnancy does not have any effect on the weight of the baby or length of pregnancy. The selenium requirements of a pregnant and lactating mother are increased as a result of selenium transport to the fetus via the placenta and to the infant via breast milk.

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“…Administration of 17-β-stradiol to Long-Evans-Hooded (LEC) rats induced increased serum copper and ceruloplasmin [18]. In postmenopausal women, treatment with 17-β-stradiol also induced an increase of serum ceruloplasmin [19].…”

Section: Discussionmentioning

confidence: 96%

Copper and Liver Function Indicators Vary Depending on the Female Hormonal Cycle and Serum Hormone Binding Globulin (SHBG) Concentration in Healthy Women

Ayala

Pizarro

Méndez

et al. 2007

Biol Trace Elem Res

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Previous studies showed that responses to chronic administration of copper were significantly associated with gender, raising the need to better characterize the relation between the effects observed and stradiols. The objective of this study was to measure copper and liver function indicators and the sex hormone binding globulin (SHBG) serum concentrations in healthy adults exposed to copper, grouped by sex and phase of the female hormonal cycle. Healthy females on day 7 (follicular phase, Group 1, n = 39), on day 21 (secretory phase, Group 2, n = 34) and males (comparison group, Group 3, n = 34) received 8 mg Cu/day (as copper sulfate), orally, for 6 months. On days 0, 30, 60, 120, and 180, the serum concentration of copper, ceruloplasmin, liver aminotransferases, and SHBG were measured. Analysis of results included analysis of variance (ANOVA; repeated measures) and the post hoc Bonferroni correction. Participants remained healthy throughout the study period, including aminotransferases below the cut off in all measures. GGT, AST, and ALT activities were significantly different by group and by time (ANOVA repeated measures P < 0.05). Six-month curves of serum copper and ceruloplasmin concentrations were different by group, by time and interaction group x time (all P < 0.001). SHBG curves were different by group and time (P < 0.01), and interaction group x time (P < 0.009). Serum copper, ceruloplasmin, and liver aminotranferases are influenced by estrogens/progesterone, something that should be considered when these indicators are used as outcomes of effects. Time of sampling was also significantly associated with the indicators and deserves further study.

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Effect of Estrogen on Serum and Tissue Levels of Copper and Zinc

Cited by 10 publications

References 16 publications

Implant and copper oxide needles for steers grazing Acremonium coenophialum-infected tall fescue pastures: effects on grazing and subsequent feedlot performance and serum constituents

Implant and copper oxide needles for steers grazing Acremonium coenophialum-infected tall fescue pastures: effects on grazing and subsequent feedlot performance and serum constituents

Zinc, copper and selenium in reproduction

Copper and Liver Function Indicators Vary Depending on the Female Hormonal Cycle and Serum Hormone Binding Globulin (SHBG) Concentration in Healthy Women

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