Effect of Estrogen on the Activity and Growth of Human Osteoclasts In Vitro

Chen, Fangping; Wang, Kun-Chuang; Huang, Jing-Duan

doi:10.1016/s1028-4559(09)60323-5

Cited by 25 publications

(18 citation statements)

References 15 publications

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“…Postmenopausal ERT prevents bone loss and reduces fracture risk 29,30. Estrogen acts mainly by inhibiting osteoclast bone resorption and by preventing the overproduction of osteoclastogenesis-associated cytokines following the postmenopausal estrogen drop 31. …”

Section: Resultsmentioning

confidence: 99%

Piper sarmentosum enhances fracture healing in ovariectomized osteoporotic rats: a radiological study

Estai

Suhaimi

Das

et al. 2011

Clinics

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INTRODUCTION:Osteoporotic fractures are common during osteoporotic states. Piper sarmentosum extract is known to possess antioxidant and anti-inflammatory properties.OBJECTIVES:To observe the radiological changes in fracture calluses following administration of a Piper sarmentosum extract during an estrogen-deficient state.METHODS:A total of 24 female Sprague-Dawley rats (200-250 g) were randomly divided into 4 groups: (i) the sham-operated group; (ii) the ovariectomized-control group; (iii) the ovariectomized + estrogen-replacement therapy (ovariectomized-control + estrogen replacement therapy) group, which was supplemented with estrogen (100 µg/kg/day); and (iv) the ovariectomized + Piper sarmentosum (ovariectomized + Piper sarmentosum) group, which was supplemented with a water-based Piper sarmentosum extract (125 mg/kg). Six weeks after an ovariectomy, the right femora were fractured at the mid-diaphysis, and a K-wire was inserted. Each group of rats received their respective treatment for 6 weeks. Following sacrifice, the right femora were subjected to radiological assessment.RESULTS:The mean axial callus volume was significantly higher in the ovariectomized-control group (68.2±11.74 mm3) than in the sham-operated, estrogen-replacement-therapy and Piper sarmentosum groups (20.4±4.05, 22.4±4.14 and 17.5±3.68 mm3, respectively). The median callus scores for the sham-operated, estrogen-replacement-therapy and Piper sarmentosum groups had median (range, minimum - maximum value) as 1.0 (0 - 2), 1.0 (1 - 2) and 1.0 (1 - 2), respectively, which were significantly lower than the ovariectomized-control group score of 2.0 (2 - 3). The median fracture scores for the sham-operated, estrogen-replacement-therapy and Piper sarmentosum groups were 3.0 (3 - 4), 3.0 (2 - 3) and 3.0 (2 - 3), respectively, which were significantly higher than the ovariectomized-control group score of 2.0 (1 - 2) (p<0.05).CONCLUSION:The Piper sarmentosum extract improved fracture healing, as assessed by the reduced callus volumes and reduced callus scores. This extract is beneficial for fractures in osteoporotic states.

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Section: Resultsmentioning

confidence: 99%

Piper sarmentosum enhances fracture healing in ovariectomized osteoporotic rats: a radiological study

Estai

Suhaimi

Das

et al. 2011

Clinics

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“…Estrogen is a major regulator of bone growth, influencing the sexual dimorphism of the skeleton and the maintenance of bone mineral homeostasis, which in turn alters both the development of bone strength and the acquisition of peak bone mass (Berger et al, 2010). Estrogens act on bone by regulating bone tissue metabolism, primarily through associations with the promotion of osteoblastic activity and the suppression of osteoclastic resorption (Dempster, 2006, Almeida, 2010, Chen et al, 2009, Zallone, 2006, Tremollieres, 2013). In women, the effects of estrogen on the skeleton appear most notably during adolescence and after menopause.…”

Section: Introductionmentioning

confidence: 99%

The associations of exposure to combined hormonal contraceptive use on bone mineral content and areal bone mineral density accrual from adolescence to young adulthood: A longitudinal study

et al. 2016

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BackgroundThe association of long term combined hormone based contraceptives (CHC) use on bone mineral content (BMC) and areal bone mineral density (aBMD) development remains controversial, as it appears that the relationship may be age-dependent. The purpose of this study was to investigate the long-term associations of CHC exposure on the accrual of bone parameters from adolescence into young-adulthood.Methods110 women (67 exposed to CHC) were drawn from the Pediatric Bone Mineral Accrual Study (PBMAS). Serial measures of total body (TB), lumbar spine (LS) and femoral neck (FN) BMC and aBMD were assessed by DXA (a total of 950 scans) and aligned by biological age (BA, years from peak height velocity [PHV]). Multilevel random effects models were constructed to assess the time dependent associations between annual CHC exposure and the development of bone parameters.ResultsAfter BA, height, lean tissue mass, fat mass, calcium and vitamin D intake, and physical activity were controlled, it was observed that those individuals exposed to CHC 6-years post PHV developed significantly less (−0.00986 ± 0.00422 g/cm2) TB aBMD than their non CHC exposed peers. Additionally, there were significant BA by CHC exposure interactions, where CHC exposure 6-years or more post PHV resulted in developing less TB BMC (−4.94 ± 2.41 g), LS BMC (−0.29 ± 0.11 g) and LS aBMD (−0.00307 ± 0.00109 g/cm2). One year after the attainment of PHV, CHC users were predicted to have 1.2% more TB BMC, 3.8% more LS BMC and 1.7% more LS aBMD than non-users. At 9-years post PHV the predicted differences showed that CHC users had 0.9% less TB BMC and 2.7% less LS BMC and 1.6% less LS BMD than those not exposed to CHC.ConclusionsCHC may not hinder the development of BMC or aBMD during adolescence; however, exposure 6-years or more after PHV may be detrimental.

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“…The duration of contraceptive pill use was significantly shorter in the LMWH-group than in the control group, because combined oral contraceptives (COCs) are contraindicated after the first VTE. Estrogens have been found to be important factors in the regulation of bone metabolism by suppressing osteoclastogenesis and inhibiting bone resorption by osteoclasts [28]. A systematic review with 129 studies concerning hormonal contraception and bone metabolism [29] found, that COCs have no significant effects on BMD in adulthood.…”

Section: Discussionmentioning

confidence: 99%

Prolonged low-molecular-weight heparin use during pregnancy and subsequent bone mineral density

Galambosi

Hiilesmaa

Ulander

et al. 2016

Thrombosis Research

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Effect of Estrogen on the Activity and Growth of Human Osteoclasts In Vitro

Abstract: Estrogen not only suppresses osteoclastogenesis but also inhibits the activity of osteoclasts.

Cited by 25 publications

References 15 publications

Piper sarmentosum enhances fracture healing in ovariectomized osteoporotic rats: a radiological study

Piper sarmentosum enhances fracture healing in ovariectomized osteoporotic rats: a radiological study

The associations of exposure to combined hormonal contraceptive use on bone mineral content and areal bone mineral density accrual from adolescence to young adulthood: A longitudinal study

Prolonged low-molecular-weight heparin use during pregnancy and subsequent bone mineral density

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