Effect of Estrogen on the Expression of Cytokines of the Temporomandibular Joint Cartilage Cells of the Mouse

Yun, Kyoung-In; Chae, Chang-Hoon; Lee, Cheol-Won

doi:10.1016/j.joms.2008.01.034

Cited by 21 publications

(14 citation statements)

References 42 publications

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“…The same proinflammatory cytokines found in allergic rhinitis secretion were observed in the condylar cartilage of the TMJ in mice, after being induced with estrogen (17β-estradiol) (8,19), which suggests that a specific immune response might be a common cause of these diseases. However, chronic disease might heighten anxiety or fear of signs of TMD, thereby increasing the likelihood of medical consultation and, thus, the risk of bias.…”

Section: Discussionsupporting

confidence: 52%

“…These include general joint hypermobility, orofacial trauma, and bacterial infection (7,10,11). Incidence appears to be higher in females (6), and studies in mice indicate that gonadal hormones are involved in the inflammatory processes of TMJ cartilage (8).…”

Section: Introductionmentioning

confidence: 99%

“…Numerous predictors of TMJD development have been proposed (4,(6)(7)(8)(9)(10). These include general joint hypermobility, orofacial trauma, and bacterial infection (7,10,11).…”

Section: Introductionmentioning

confidence: 99%

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Are there early signs that predict development of temporomandibular joint disease?

Fredricson

Khodabandehlou

Weiner

et al. 2018

Journal of Oral Science

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Temporomandibular joint disorders(TMJD) involve orofacial pain and functional limitations that may limit important daily activities such as chewing and speaking. This observational casecontrol study attempted to identify factors associated with TMJD development, particularly inflammation. The study participants were patients treated at Karolinska University Hospital, Stockholm, Sweden. The cases were patients who received a diagnosis of TMJD, chronic closed lock, or painful clicking and were treated surgically during the period from 2007 through 2011. The control group was randomly selected from among patients who had undergone tooth extraction and was matched by age and sex. A total of 146 cases and 151 controls were included in the analyses. The response rate was 55.3% for the case group and 21.8% for the control group. The male:female ratio for patients with TMJD was 1:4.4. TMJD was significantly associated with pneumonia (odds ratio [OR], 2

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Section: Discussionsupporting

confidence: 52%

Section: Introductionmentioning

confidence: 99%

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Are there early signs that predict development of temporomandibular joint disease?

Fredricson

Khodabandehlou

Weiner

et al. 2018

Journal of Oral Science

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“…In our study, we found that with increased 17β‐estradiol, IL‐8Rβ expression was upregulated and other have demonstrated that upregulation of IL‐8Rβ causes Ca 2+ ‐regulated opioid release from polymorphonuclear cells and thereby inhibits inflammatory pain (Rittner et al, 2006). In addition, studies have also shown other cytokines such as IL‐6 (Yun et al, 2008; Torres‐Chavez et al, 2010), IL‐1β and IL‐8 (Yun et al, 2008) are modulated in the TMJ tissues after estrogen administration. Our study did not observe any affect on these cytokines.…”

Section: Discussionmentioning

confidence: 99%

Estrogen in cycling rats alters gene expression in the temporomandibular joint, trigeminal ganglia and trigeminal subnucleus caudalis/upper cervical cord junction

2011

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Females report temporomandibular joint (TMJ) pain more than men and studies suggest estrogen modulates this pain response. Our goal in this study was to determine genes that are modulated by physiological levels of 17β-estradiol that could have a role in TMJ pain. To complete this goal, saline or complete Freund's adjuvant was injected in the TMJ when plasma 17β-estradiol was low or when it was at a high proestrus level. TMJ, trigeminal ganglion and trigeminal subnucleus caudalis/upper cervical cord junction (Vc/C 1-2 ) tissues were isolated from the treated rats and expression of 184 genes was quantitated in each tissue using real time PCR. Significant changes in the amount of specific transcripts were observed in the TMJ tissues, trigeminal ganglia and Vc/ C 1-2 region when comparing rats with high and low estrogen. GABA A receptor subunit α6 (Gabra6) and the glycine receptor α2 (Glra2) were two genes of interest because of their direct function in neuronal activity and a greater than 29 fold increase in the trigeminal ganglia was observed in proestrus rats with TMJ inflammation. Immunohistochemical studies showed that Gabrα6 and Glrα2 neuronal and not glial expression increased when comparing rats with high and low estrogen. Estrogen receptors α and β are present in neurons of the trigeminal ganglia, whereby 17β-estradiol can alter expression of Gabrα6 and Glrα2. Also, estrogen receptor α (ERα) but not ERβ was observed in satellite glial cells of the trigeminal ganglia. These results demonstrate that genes associated with neurogenic inflammation or neuronal excitability were altered by changes in the concentration of 17β-estradiol.

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“…Estrogen decreased cartilage thickness by inhibition of chondrocyte proliferation and increased chondrocyte maturation []. Estrogen has the potential to cause temporomandibular joint disease with induction of the proinflammatory cytokines, interleukin (IL)‐1 beta, IL‐6, and IL‐8 []. For this reason, no men were included in this study to avoid skewing the cephalometric measurements with sex‐related differences.…”

Section: Discussionmentioning

confidence: 99%

Factors related to the prevalence of anterior disc displacement without reduction and bony changes of the temporomandibular joint in patients with facial asymmetry

Ooi

Inoue

Minowa

et al. 2012

Oral Science International

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a b s t r a c tPurpose: The aim of the study was to determine the factors related to the prevalence of anterior disc displacement without reduction (ADDwoR) and bony changes of the mandibular condyle (bony changes) in temporomandibular joints (TMJs) of patients with dentofacial deformity exhibiting facial asymmetry. Patients and methods: A total of 75 female patients (150 joints) with facial asymmetry, who had undergone orthognathic surgery, were examined with magnetic resonance imaging (MRI) of the TMJ and cephalometric analysis. Logistic regression analysis was performed to determine whether there was a statistically significant association between age, cephalometric measurements, and prevalence of ADDwoR and bony changes. Results: Facial asymmetry, the prevalence of ADDwoR, and bony changes were more frequently found on the left side than that of the right side. Unilateral ADDwoR (n = 28) and unilateral bony changes (n = 14) were only found on the deviated side. The difference between the distance of upper incisal midpoints and lower incisal midpoints from the facial midline (U1-L1 distance) was significantly larger in 36 patients with ADDwoR and 52 patients with bony changes. According to logistic regression analysis, U1-L1 distance might be related to the prevalence of ADDwoR and bony changes in the TMJs with facial asymmetry. Conclusion: U1-L1 distance related to the prevalence of ADDwoR and bony changes in TMJs of patients with dentofacial deformity exhibiting facial asymmetry.

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Effect of Estrogen on the Expression of Cytokines of the Temporomandibular Joint Cartilage Cells of the Mouse

Cited by 21 publications

References 42 publications

Are there early signs that predict development of temporomandibular joint disease?

Are there early signs that predict development of temporomandibular joint disease?

Estrogen in cycling rats alters gene expression in the temporomandibular joint, trigeminal ganglia and trigeminal subnucleus caudalis/upper cervical cord junction

Factors related to the prevalence of anterior disc displacement without reduction and bony changes of the temporomandibular joint in patients with facial asymmetry

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