Effect of ethanol and fructose on plasma uridine and purine bases

Yamamoto, Tetsuya; Moriwaki, Yuji; Takahashi, Sumio; Yamakita, Jun-ichi; Tsutsumi, Zenta; Ohata, Hiroyuki; Hiroishi, Keisai; Nakano, Takashi; Higashino, Kazuya

doi:10.1016/s0026-0495(97)90192-x

Cited by 43 publications

(28 citation statements)

References 11 publications

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“…Oral challenge with 70 g of fructose caused the rise in serum uric acid levels in kidney transplant recipients [19]. Similarly, in healthy subjects, an intravenous load of fructose (1.0 g per kg of body weight) increased plasma concentration of uric acid [29]. In our study, the fructose load related to apple juice consumption was about 90 g, with the maximal rise in the concentration of uric acid observed at first hour after juice ingestion and was paralleled by peak of FRAP and serum DPPH radical-scavenging activity.…”

Section: Apple Juice and Plasma Antioxidant Activitymentioning

confidence: 93%

Uric Acid but Not Apple Polyphenols Is Responsible for the Rise of Plasma Antioxidant Activity after Apple Juice Consumption in Healthy Subjects

Godycki-Ćwirko¹,

Król²,

Król

et al. 2010

Journal of the American College of Nutrition

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We have demonstrated that rapid consumption of apple juice increased plasma antioxidant activity in healthy subjects; this was caused by the fructose-induced rise of serum uric acid levels, but was not due to the presence of antioxidant polyphenols in juice. Thus, short-term consumption of apple juice seems not to be the effective dietary intervention to augment plasma antioxidant activity due to the concomitant possibility for uric acid to be a risk factor for several diseases, as verified by other authors.

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Section: Apple Juice and Plasma Antioxidant Activitymentioning

confidence: 93%

Uric Acid but Not Apple Polyphenols Is Responsible for the Rise of Plasma Antioxidant Activity after Apple Juice Consumption in Healthy Subjects

Godycki-Ćwirko¹,

Król²,

Król

et al. 2010

Journal of the American College of Nutrition

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“…When ethanol or amino acids are loaded in normal subjects, both purine degradation and pyrimidine degradation are enhanced [18,19]. These two metabolic pathways are closely related.…”

Section: Nucleoside and Nucleotide Contents In Foods And Beveragesmentioning

confidence: 99%

“…IMP is an important compound in purine metabolism that is both a product of purine de novo synthesis and a product of the salvage pathway from hypoxanthine. Moreover, pyrimidine metabolism has recently been reported to be related to purine metabolism [18,19].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of nucleosides and nucleotides in dietary foods and beverages using ion-pairing liquid chromatography–electrospray ionization-mass spectrometry

Yamaoka

Kudo

Inazawa

et al. 2010

Journal of Chromatography B

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“…Yamamoto et al [26], in their study on the effect of ethanol and fructose on purine and pyrimidine metabolism, showed an increase in the concentration of purine bases and uridine in plasma. Both ethanol and fructose increased the plasma concentration of uridine together with an increase in the plasma concentration of oxypurines, whereas fructose also increased the plasma concentration of uric acid, while ethanol did not.…”

Section: Discussionmentioning

confidence: 99%

Blood uridine concentration may be an indicator of the degradation of pyrimidine nucleotides during physical exercise with increasing intensity

et al. 2010

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During prolonged maximal exercise, oxygen deficits occur in working muscles. Progressive hypoxia results in the impairment of the oxidative resynthesis of ATP and increased degradation of purine nucleotides. Moreover, ATP consumption decreases the conversion of UDP to UTP, to use ATP as a phosphate donor, resulting in an increased concentration of UDP, which enhances pyrimidine degradation. Because the metabolism of pyrimidine nucleotides is related to the metabolism of purines, in particular with the cellular concentration of ATP, we decided to investigate the impact of a standardized exercise with increasing intensity on the concentration of uridine, inosine, hypoxanthine, and uric acid. Twenty-two healthy male subjects volunteered to participate in this study. Blood concentrations of metabolites were determined at rest, immediately after exercise, and after 30 min of recovery using high-performance liquid chromatography. We also studied the relationship between the levels of uridine and indicators of myogenic purine degradation. The results showed that exercise with increasing intensity leads to increased concentrations of inosine, hypoxanthine, uric acid, and uridine. We found positive correlations between blood uridine levels and indicators of myogenic purine degradation (hypoxanthine), suggesting that the blood uridine level is related to purine metabolism in skeletal muscles.

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Effect of ethanol and fructose on plasma uridine and purine bases

Cited by 43 publications

References 11 publications

Uric Acid but Not Apple Polyphenols Is Responsible for the Rise of Plasma Antioxidant Activity after Apple Juice Consumption in Healthy Subjects

Uric Acid but Not Apple Polyphenols Is Responsible for the Rise of Plasma Antioxidant Activity after Apple Juice Consumption in Healthy Subjects

Simultaneous determination of nucleosides and nucleotides in dietary foods and beverages using ion-pairing liquid chromatography–electrospray ionization-mass spectrometry

Blood uridine concentration may be an indicator of the degradation of pyrimidine nucleotides during physical exercise with increasing intensity

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