Effect of Ethanol Extract of &lt;i&gt;Indigofera tinctoria&lt;/i&gt; Linn (Fabaceae) on Lithium/Pilocarpine-Induced Status Epilepticus and Oxidative Stress in Wistar Rats

Asuntha, G.; Prasannaraju, Y.; Prasad, K. V. S. R. G.

doi:10.4314/tjpr.v9i2.53702

Cited by 24 publications

(17 citation statements)

References 19 publications

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“…In a previous survey carried out in Lagos and Ogun States by Sonibare et al (2008) (Asuntha et al, 2010;Almeida et al, 2013;Adzu et al, 2002). Chenopodium ambrosioides (Cavalli et al, 2005;Ibironke and Ajiboye, 2007), J. curcas (Uche et al, 2008), Anacardium occidentale (Olajide et al, 2013;Maia et al, 2000), A. africanus (Hassan et al, 2008), S. guineense (Ior et al, 2012) have documented analgesic and anti-inflammatory properties however there is no report of neuropharmacological activity.…”

Section: Comparison Of Ethno-medicinal Use Of These Plants With Othermentioning

confidence: 99%

Ethnobotanical survey of plants used in the management of mental illnesses in some selected local government areas of Plateau State, Nigeria

Ior¹,

Otimenyin²,

Okwori³

et al. 2017

J. Pharmacognosy Phytother.

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Mental illness refers to all diagnosable mental disorders which are characterised by abnormalities in thinking, feelings or behaviours. Ethnobotanical study surveyed the different types of medicinal plants used for the treatment of mental illness in Bassa, Pankshin, and Kanke Local Government Areas of Plateau State, Nigeria. Information was obtained from traditional medicine practitioners, herbalist and herb sellers, with the aid of semi structured questionnaire. Plant samples were collected and identified by taxonomists in the herbarium section of Federal College of Forestry Jos and Ahmadu Bello University Zaria, Nigeria. The information was obtained from a total of 35 respondents. Forty two plants were identified from the study, from 31 families. The source, uses, plant parts, and methods of preparation were some of the information derived. The family with the highest number of represented species was Lamiaceae accounting for 10% with a user value of 0.035. The dominant route of administration employed for drug delivery was oral accounting for up to 80% (56% as strictly oral). The plant parts mostly collected by the respondents for management of the conditions reported are leaves amounting to 51%. Some of the plants have recorded scientific values for neuropharmacological activities, whereas others are yet to be tested. It is important to validate these plants scientifically for possible neuropharmacological properties that may be harnessed for future use.

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Section: Comparison Of Ethno-medicinal Use Of These Plants With Othermentioning

confidence: 99%

Ethnobotanical survey of plants used in the management of mental illnesses in some selected local government areas of Plateau State, Nigeria

Ior¹,

Otimenyin²,

Okwori³

et al. 2017

J. Pharmacognosy Phytother.

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“…The decreases in MDA and increase in the glutathione level in EEDT+PTZ mice indicates that EEDT exerted good antioxidant effect. Several studies also indicates that on medicinal plants antioxidant activities are due to the presence of polyphenols and flavonoids (Asuntha et al, 2010). Phytochemical studies indicates the presence of phenolic compounds and flavonoids in D. triflorum.…”

Section: Evaluation Of Anticonvulsant Activity Of Ethanolic Leaves Exmentioning

confidence: 99%

Evaluation of anticonvulsant activity of ethanolic leaves extract of Desmodium triflorum in mice

Gowda¹,

Bhosle²,

Einstein³

et al. 2012

Rev. bras. farmacogn.

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The present investigation was aimed to study an anticonvulsant activity of ethanolic extract of Desmodium triflorum (L.) DC., Fabaceae, in mice. Animal models of epilepsy namely the pentylenetetrazole (PTZ), isoniazid or isonicotinic hydrazide (INH) and maximal electroshock induced convulsion (MES) were used to evaluate the anticonvulsant effects of the extracts. The biochemical estimation was done by measuring the lipid peroxidation and reduced glutathione (GSH). In the PTZ induced convulsion, ethanolic extract of D. triflorum (EEDT) 400 mg/kg significant delayed the onset of convulsion, reduced the duration of convulsion and reduced mortality. Similarly a dose of 800 mg/kg of EDDT significantly delayed the onset of convulsion, reduced the duration of convulsion and showed 33.33% protection in mice against INH induced convulsion. Further no mortality was found. Both the doses reduced hind limb tonic extension (HLTE) phase of MES induced convulsion in mice. The pretreated EEDT showed significant inhibition of lipid peroxidation and increases the reduced glutathione level in mice brain tissue. The results revealed that D. triflorum possesses a significant dose dependent anticonvulsant activity.

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“…The plant Indigofera tinctoria known as Neeli in Tamil and belongs to the family Fabaceae which popularly found throughout India. The plant roots, stems, and leaves of I. tinctoria are bitter and used as thermogenic, laxative, trichogenous, expectorant, anthelmintic, gastropathy, splenomegaly, cardiopathy, hepatoprotective, anticancer, epilepsy, neuropathy, chronic bronchitis, and diuretic and also useful for promoting the growth of hair [8,9]. The present investigation of the cardioprotective effect of ethanolic extract of Indica tinctoria (EEIT) against isoproterenol-induced AMI in rats as preventive model was conducted.…”

Section: Introductionmentioning

confidence: 99%

Cardioprotective Effect of Indigofera Tinctoria Linn. Against Myocardial Infarction-Induced Rats

Puligilla¹,

Priyanka²

2018

Asian J Pharm Clin Res

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Objective: The aim and objective of the present study are to study the protective effects of ethanolic extract of Indica tinctoria (EEIT) in isoproterenolinduced acute myocardial infarction (AMI) in rats. Methods:The effect of two doses of isoproterenol (5 mg/kg and 8.5 mg/kg body weight) changes in aspartate transaminase (AST), alanine transaminase (ALT), lactate dehydrogenase (LDH), creatine phosphokinase (CPK), and total protein (TP) and lipid hydroperoxides, superoxide dismutase (SOD), and glutathione (GSH) in blood serum and heart homogenate, for the two consecutive days (29 and 30), were administered subcutaneously in rats in pre-treatment with EEIT for the 28-day study.Results: There was increased the AST, ALT, LDH, CPK, and lipid peroxides levels and decreased the TP, SOD, GSH with Isoproterenol-induced group. Pre-treatment for 28 days with Indigofera tinctoria significantly (p<0.05) increased antioxidants (SOD , GSH) , TP levels and decreased the cardiotoxic agents significantly (p<0.05) such as LPO, AST, ALT, LDH, and CPK levels in treatment groups. Conclusion:I. tinctoria contains beneficial bioactive photochemicals that have been protective effective against isoproterenol-induced AMI in rats.

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Effect of Ethanol Extract of <i>Indigofera tinctoria</i> Linn (Fabaceae) on Lithium/Pilocarpine-Induced Status Epilepticus and Oxidative Stress in Wistar Rats

Cited by 24 publications

References 19 publications

Ethnobotanical survey of plants used in the management of mental illnesses in some selected local government areas of Plateau State, Nigeria

Ethnobotanical survey of plants used in the management of mental illnesses in some selected local government areas of Plateau State, Nigeria

Evaluation of anticonvulsant activity of ethanolic leaves extract of Desmodium triflorum in mice

Cardioprotective Effect of Indigofera Tinctoria Linn. Against Myocardial Infarction-Induced Rats

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