Effect of ethanol in single dose on liver of ethanol-treated and nontreated mice

Mirone, Leonora

doi:10.1152/ajplegacy.1966.210.2.390

Cited by 7 publications

(3 citation statements)

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“…As noted above, alcohol administered acutely does not generally decrease whole-body glucose Ra but does markedly suppress gluconeogenesis. This metabolic scenario is consistent with alcohol acutely stimulating hepatic glycogenolysis under fed or short-term fasted conditions to defend against the development of hypoglycemia [ 9 , 11 , 45 , 46 , 47 ]. Many studies indicate that chronic alcohol intake decreases whole liver glycogen content [ 47 , 48 , 49 ] which occurs in both periportal and perivenous hepatocytes [ 50 ], and is consistent with the observed reduction in basal glycogen synthase activity.…”

Section: Alcohol and Basal Glucose Homeostasissupporting

confidence: 63%

“…This metabolic scenario is consistent with alcohol acutely stimulating hepatic glycogenolysis under fed or short-term fasted conditions to defend against the development of hypoglycemia [ 9 , 11 , 45 , 46 , 47 ]. Many studies indicate that chronic alcohol intake decreases whole liver glycogen content [ 47 , 48 , 49 ] which occurs in both periportal and perivenous hepatocytes [ 50 ], and is consistent with the observed reduction in basal glycogen synthase activity. The decrease in hepatic glycogen appears to result from the ability of alcohol to inhibit the repletion of glycogen reserves which is directly related to the concomitant inhibition of gluconeogenesis [ 9 , 46 , 49 ].…”

Section: Alcohol and Basal Glucose Homeostasissupporting

confidence: 63%

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Impact of Alcohol on Glycemic Control and Insulin Action

2015

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Alcohol has profound effects on tissue and whole-body fuel metabolism which contribute to the increased morbidity and mortality in individuals with alcohol use disorder. This review focuses on the glucose metabolic effects of alcohol, primarily in the muscle, liver and adipose tissue, under basal postabsorptive conditions and in response to insulin stimulation. While there is a relatively extensive literature in this area, results are often discordant and extrapolating between models and tissues is fraught with uncertainty. Comparisons between data generated in experimental cell and animals systems will be contrasted with that obtained from human subjects as often times results differ. Further, the nutritional status is also an important component of the sometimes divergent findings pertaining to the effects of alcohol on the regulation of insulin and glucose metabolism. This work is relevant as the contribution of alcohol intake to the development or exacerbation of type 2 diabetes remains ill-defined and a multi-systems approach is likely needed as both alcohol and diabetes affect multiple targets within the body.

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Section: Alcohol and Basal Glucose Homeostasissupporting

confidence: 63%

Section: Alcohol and Basal Glucose Homeostasissupporting

confidence: 63%

Impact of Alcohol on Glycemic Control and Insulin Action

2015

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“…The metabolic response to ethanol differs between fed and fasted subjects and is seen mainly in the change produced in circulating glucose. In the fed state ethanol may produce hyperglycemia (Ammon and Estler, 1967;Tennet, 1941) due to its enhancing effect on hepatic glycogenolysis (Mirone, 1966). In starvation, when liver glycogen stores are low, ethanol causes hypoglycemia (Bleicher et al, 1964;Freinkel et al, 1965a) due to liver gluconeogenesis inhibition secondary to changes in the intracellular redox state caused by ethanol oxidation (Freinkel et al, 1965b;Krebs et al, 1969;Madison et al, 1967).…”

Section: Introductionmentioning

confidence: 99%