Effect of ethanol intake on the incorporation of labelled amino acids into liver protein

Mørland, Jörg; Sjetnan, Anne E.

doi:10.1016/0006-2952(76)90123-4

Cited by 22 publications

(3 citation statements)

References 23 publications

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“…Decreased protein degradation after 2 weeks could explain these results, since protein synthesis was unaffected. The observed change with time in protein metabolism could explain some of the conflicting results reported both with regard to hepatic protein synthesis (Noble & Tewari 1973;Msrland & Sjetnan 1976;Baraona et al 1977;Msrland et al 1979 198 1) may influence the outcome of the experiment. Inhibition of protein export from liver could also contribute to the protein accumulation (Baraona et al 1977).…”

Section: Discussionmentioning

confidence: 97%

“…From 2 to 8 weeks the inhibition of protein synthesis developed, and the hepatic protein level was normalized. The observed change with time in protein metabolism could explain some of the conflicting results reported both with regard to hepatic protein synthesis (Noble & Tewari 1973;Msrland & Sjetnan 1976;Baraona et al 1977;Msrland et al 1979) 198 1) may influence the outcome of the experiment. Also, it should be kept in mind that the rate of protein synthesis as measured in short term labelling experiments like the present, will mainly reflect the overall synthesis of proteins with rapid turnover and thus may not represent synthesis of all liver proteins to the same extent (Schworer et al 1981).…”

Section: Discussionmentioning

confidence: 97%

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A Study of Hepatic Protein Synthesis, Three Subcellular Enzymes, and Liver Morphology in Chronically Ethanol Fed Rats

Smith-Kielland

Blom

Svendsen

et al. 1983

Acta Pharmacologica et Toxicologica

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Male Wistar rats were given ethanol chronically (20-30% of the energy as ethanol) in a nutritionally sufficient regimen. Controls received lipid as isoenergetic substitute for ethanol. Treatment lasted for 2 or 8 weeks. Hepatic protein synthesis was measured in fasted rats during a 32 min. continuous infusion of 'H-valine.After 2 weeks of treatment accumulation of hepatic protein was observed in the ethanol group, but there was no change in hepatic protein synthesis or morphology. After 8 weeks the rate of hepatic protein synthesis was decreased by 35% in the ethanol group, but there was no accumulation of protein and a slight accumulation of intracellular lipid droplets. Neither the subcellular distribution of incorporated 'H-valine, nor the activities and distributions of alcohol dehydrogenase and NADPH cytochrome c reductase were changed. Mitochrondrial cytochrome c oxidase activity was decreased in the ethanol group, and cytosolic and microsomal fractions showed higher cytochrome c oxidase activity in this group. Chronic ethanol treatment for 8 weeks had an adverse effect on general protein synthesis as well as on a specific enzyme in the liver in the absence of serious morphologic abnormalities.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 97%

A Study of Hepatic Protein Synthesis, Three Subcellular Enzymes, and Liver Morphology in Chronically Ethanol Fed Rats

Smith-Kielland

Blom

Svendsen

et al. 1983

Acta Pharmacologica et Toxicologica

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“…The finding that the polysome profile was not significantly affected in this experiment is somewhat at variance with the results in mice in which the aggregational state of the ribosomes was slightly enhanced after 4-8 weeks' ethanol drinking (Hopf et al 1986b). The reason for this discrepan- (Banks et al 1970;Morland 1974;Rothschild et al 1975;Morland and Sjetnan 1976;Lieber 1980).…”

Section: Ethanol Treatmentmentioning

confidence: 99%

Investigation into the combined effects of ethanol and cadmium on rat liver and kidneys

Hopf¹,

Böcker²,

Bischoff³

et al. 1990

Arch Toxicol

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To examine the combined hepatotoxic and nephrotoxic effects of cadmium and ethanol, rats maintained on an ethanol containing liquid diet (5% w/w) were given cadmium either acutely (3 x 1 mg/kg IP) or subacutely (about 14 mg/kg/day PO for 6 weeks). Parameters tested were cadmium, zinc and copper contents of blood and various organs, metallothionein (MT) contents, polysome profile of liver and kidneys, serum SDH and GPT levels and creatinine clearance. Ethanol reduced the hepatic MT contents without altering the polysome profile and the zinc and copper contents. Cadmium on the other hand raised the MT contents in liver and kidneys. This effect of cadmium predominated in the combined treatment. Morphological examination and functional tests (SDH, GPT, creatinine clearance) indicate that cadmium does not enhance the toxic effects of ethanol, and vice versa.

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Effects of Ethanol on Amino Acid and Protein Metabolism

Adibi¹,

Baraona²,

Lieber³

1992

Medical and Nutritional Complications of Alcoholism

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Effect of ethanol intake on the incorporation of labelled amino acids into liver protein

Cited by 22 publications

References 23 publications

A Study of Hepatic Protein Synthesis, Three Subcellular Enzymes, and Liver Morphology in Chronically Ethanol Fed Rats

A Study of Hepatic Protein Synthesis, Three Subcellular Enzymes, and Liver Morphology in Chronically Ethanol Fed Rats

Investigation into the combined effects of ethanol and cadmium on rat liver and kidneys

Effects of Ethanol on Amino Acid and Protein Metabolism

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