Effect of ethanol on acid secretion by isolated gastric glands from rabbit

Ethanol Inhibits Gastric Acid Secretion in Rats Through Increased AMP-Kinase Activity

“…Chacin et al postulated that lowdose (2-20%) ethanol stimulates gastric acid secretion, whereas high concentrations (>20%) were shown to have an inhibitory effect [9]. A second group applying different concentrations (0,2-5% and >10%, respectively) came to the same conclusion [12]. In sharp contrast to these findings, other investigations concluded that acid secretion is reduced under low-dose conditions.…”

“…As a consequence, numerous attempts have been made in the past to study its effects on the ability of the stomach to produce acid [9][10][11][12]. However, the results of these studies were very ambiguous in that no consensus has been reached as to whether ethanol inhibits or stimulates gastric acid secretion [9][10][11][12].…”

“…However, the results of these studies were very ambiguous in that no consensus has been reached as to whether ethanol inhibits or stimulates gastric acid secretion [9][10][11][12]. Beside the observation that there might be a biphasic effect of ethanol distinguishing between acute and chronic exposure [31,32], the fact that many groups have employed remarkably high doses of ethanol (with up to 20% being classified as low-dose exposure) and different experimental approaches, ranging from studies in cultured cells to observations on the wholetissue level, may account for the heterogeneous past results [9][10][11][12]. In the present study we were able to demonstrate that ethanol at doses as low as 1% decreased acid secretion significantly both on the single-cell/gland and on the whole-stomach level.…”

“…As a consequence, numerous attempts have been made in the past to study its effects on the ability of the stomach to produce acid [9][10][11][12]. However, the results of these studies were very ambiguous in that no consensus has been reached as to whether ethanol inhibits or stimulates gastric acid secretion [9][10][11][12]. Beside the observation that there might be a biphasic effect of ethanol distinguishing between acute and chronic exposure [31,32], the fact that many groups have employed remarkably high doses of ethanol (with up to 20% being classified as low-dose exposure) and different experimental approaches, ranging from studies in cultured cells to observations on the wholetissue level, may account for the heterogeneous past results [9][10][11][12].…”

“…There has been a great deal of controversy as to the effects of ethanol on gastric acid secretion from being a mild stimulant to being a potent inhibitor [9][10][11][12]. However, the general consensus implicated that alcoholic beverages stimulate gastric acid secretion.…”