Effect of ethanolic preparations of cinnamon (Cinnamomum zeylanicum) extract on hematologic and histometric parameters of selected organs in Alloxan® induced diabetic female albino rats

Qureshi, Anas Sarwar; Ghaffor, Junaid; Usman, Muhammad; Ehsan, Nazia; Umar, Zaima; Sarfraz, Adeel

doi:10.1007/s40200-019-00457-4

Cited by 12 publications

(9 citation statements)

References 21 publications

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“…In this study, tumorized mice treated with Cinn exhibited a marked improvement in the total leucocytic count, RBCs count, hemoglobin content, platelet count, relative lymphocytes and granulocytes when compared to EAC control group and Cis-treated group. These outcomes were in consistent with previous work which reported that cinnamon extract improved the WBCs count, RBCs count, hemoglobin content in Alloxan-induced diabetic female albino rats 70 . Additionally, the improved effect of cinnamon on the hematological parameters in vivo was previously reported 71 , 72 .…”

Section: Discussionsupporting

confidence: 93%

Anti-proliferative and immunomodulatory potencies of cinnamon oil on Ehrlich ascites carcinoma bearing mice

Morsi

El-Nabi

Elmaghraby

et al. 2022

Sci Rep

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Cinnamon is a well-known natural spice and flavoring substance used worldwide. The objective of the present work is to explore the possible antitumor and immunomodulatory potencies of cinnamon essential oil (Cinn) on Ehrlich ascites carcinoma (EAC). A total of fifty female Swiss albino mice were sub-grouped into five groups (n = 10), namely, normal (a non-tumorized and non-treated) group; EAC-tumorized and non-treated group; Cinn (non-tumorized mice received Cinn, 50 mg/kg per body weight daily) group; a group of EAC-tumorized mice treated with Cinn and the final positive control group of EAC-tumorized mice received cisplatin. Eight compounds were identified from Cinn using UPLC-MS-Qtof and NMR analysis. Compared to EAC untreated group, Cinn successfully (P < 0.05) inhibited tumor growth by reducing tumor cell count (45%), viability (53%) and, proliferation accompanied by the inhibition of tumor growth rate. Moreover, a significant (P < 0.05) arrest in the cell cycle at G0/G1 phase was noticed following Cinn treatments (~ 24.5%) compared to EAC group. Moreover, Cinn markedly evoked an antitumor immune response by elevating the percentage of splenic T helper (CD3+CD4+) and T cytotoxic (CD3+CD8+) cells. It is noteworthy that Cinn treatments significantly restored different hematological alterations as well as liver and kidney functions in EAC-tumorized mice. In conclusion, results suggest that Cinn has a good antitumor and immunostimulatory potencies against Ehrlich ascites carcinoma in vivo. The mechanism underlying its antitumor activity may be attributed to its immunostimulatory effects which increase its potential as a promising anticancer candidate.

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Section: Discussionsupporting

confidence: 93%

Anti-proliferative and immunomodulatory potencies of cinnamon oil on Ehrlich ascites carcinoma bearing mice

Morsi

El-Nabi

Elmaghraby

et al. 2022

Sci Rep

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“…In our study, CTE treatment showed significant anti-hyperglycemic activity by bringing down the blood glucose level to near normal on day 28 in diabetic rats. Our results of significant reduction of blood glucose levels in diabetic rats by administration of herbal extract was in accordance with earlier reported results of similar nature [27,28]. Few studies were reported on the effect of supplementation of cinnamon and other herbs in type 2 diabetic populations proved to be effective in glycemic control [9,10].…”

Section: Discussionsupporting

confidence: 93%

“…Likewise, the CTE treatment partially restored the tissue architecture of liver and kidney. The organ protective potential of CTE could be attributed to its higher phenolic content which acts as free-radical scavenger, which is considered as the major chemical induced tissue degeneration pathway [27,44]. Over all, CTE was found to be effective in partial restoration of tissue damage and this fact could be explored for the treatment of patients with type 1 diabetes also.…”

Section: Discussionmentioning

confidence: 99%

Phytotherapeutic potential of bi-herbal extract of cinnamon and turmeric: in vivo antidiabetic studies

2021

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Background The spices, cinnamon and turmeric have both culinary and pharmaceutical applications. Earlier studies proved their effect on reducing the symptoms associated with type 2 diabetes, a major lifestyle disease affecting millions world over. In our work, we prepared a bi-herbal extract of cinnamon and turmeric and studied its effect to alleviate the symptoms of type 2 diabetes in rat model. Method The phenolic rich bi-herbal extract was given to diabetes induced male wistar rats for 28 days at two different concentrations (50 and 150 mg/Kg bwt.). The changes in blood glucose level were monitored at weekly interval. At the end of the experiment, blood serum was collected and used for the estimation of lipid profile, Glucose, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), Total Protein (TP), Albumin, Urea and Creatinine levels. Result The serum analysis revealed that administration of the bi-herbal extract at 150 mg/Kg bwt. significantly reduced the blood glucose level (152.60 ± 40.2 mg/dL; p < 0.05) of diabetic animals as compared to diabetic control (335.40 ± 67.3 mg/dL; p < 0.05) at the end of 4 weeks. The treatment also resulted in the reduction of total cholesterol and LDL-cholestrol levels as compared to diabetic control animals. The histopathological examination of tissues showed the improvement in pancreatic architecture and restoration of tissue integrity in liver and kidney. Conclusion The study concludes that methanol extract of combination of cinnamon and turmeric has good hypoglycemic, hypolipidemic and organ protective potential in diabetic rats which could be developed into functional food supplementation for the prevention of type 2 diabetes.

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“…The blood sample was collected from the animals' eyes using nonheparinized capillary tubes, and hematological parameters were performed as per the reported procedure [ 32 ]. The determined parameters include platelet count, total leukocyte count, hemoglobin, WBCs, and RBCs.…”

Section: Methodsmentioning

confidence: 99%

Ficus carica and Sizigium cumini Regulate Glucose and Lipid Parameters in High-Fat Diet and Streptozocin-Induced Rats

Arafa

Hassan

Murtaza

et al. 2020

Journal of Diabetes Research

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Obesity linked diabetes, popularly known as diabesity, has been viewed as a direct product of the modern lifestyle in both developed and developing countries, and its increased prevalence is seen as a major threat to public health globally. Ficus carica (FC) and Syzigium cumini (SC) are part of indigenous flora with traditional medicinal properties. Fresh seeds of SC fruit and fruit of FC were collected and macerated to obtain the final extract. Wistar rats were divided into seven groups fed either on a normal diet or high-fat diet (HFD) along with streptozocin (STZ) to induce diabesity. The crude extract of FC (FC.Cr.) and SC (SC.Cr.) were administered at 250 mg/kg/day and 500 mg/kg/day in induced diabesity state. Body weights, blood glucose level, complete blood count (CBC), cholesterol, triglycerides (TG), low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL), and high-density lipoprotein (HDL) were recorded to analyze their effects on glucose and lipid metabolism. Further, superoxide dismutase (SOD) and malondialdehyde (MDA) were measured to examine their effects on lipid peroxidation and ant oxidative enzyme. Results showed that both FC.Cr. and SC.Cr. have the potential to control obesity-linked type 2 diabetes mellitus (T2DM) by lowering the body weights, serum glucose, cholesterol, TG, LDL, and VLDL, while increasing the protective effects of HDL dose-dependently. The crude extract of both plants showed significant activity to raise SOD and curb MDA under diabetic states. It was concluded that both FC.Cr. and SC.Cr. exhibited remarkable therapeutics potential in HFD-STZ-induced diabetic rats. However, we found that the effects of SC.Cr. are relatively more pronounced as compared to FC.Cr. in almost all parameters.

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Effect of ethanolic preparations of cinnamon (Cinnamomum zeylanicum) extract on hematologic and histometric parameters of selected organs in Alloxan® induced diabetic female albino rats

Cited by 12 publications

References 21 publications

Anti-proliferative and immunomodulatory potencies of cinnamon oil on Ehrlich ascites carcinoma bearing mice

Anti-proliferative and immunomodulatory potencies of cinnamon oil on Ehrlich ascites carcinoma bearing mice

Phytotherapeutic potential of bi-herbal extract of cinnamon and turmeric: in vivo antidiabetic studies

Ficus carica and Sizigium cumini Regulate Glucose and Lipid Parameters in High-Fat Diet and Streptozocin-Induced Rats

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