Effect of ethanolic seed extract of Croton penduliflorous Hutch. on loperamide-induced constipated male rats

Ashafa, Anofi Omotayo Tom; Yakubu, Musa Toyin; Ogbe, Abdulazeez A.; Abass, Aishat Abidemi

doi:10.3329/bjp.v7i1.10120

Cited by 1 publication

(2 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Loperamide is commonly employed in animal models to induce spastic constipation (Ashafa et al, 2012;Zhou et al, 2013) and is frequently used for the assessment of laxative potential of test materials. Loperamide is known to inhibit fecal mass production and delay its evacuation through inhibition of gastrointestinal secretions and motility (Hughes et al, 1984;Yamada and Onoda, 1993).…”

Section: Discussionmentioning

confidence: 99%

“…Herbal medicines are beneficial over the drugs as they modify the stool consistency to make defecation easier rather than to defect the neuromuscular function of bowel, which produces undesirable effects. Variety of medicinal herbs are popular for the treatment of constipation like Oligochaeta ramose (Hussain et al, 2014), Carissa carandas (Mehmood et al, 2014), Croton penduliflorus (Ashafa et al, 2012), Ficus carica (Lee et al, 2012), Chrozophora prostrate (Arshad et al, 2012), ispaghula and ginger (Ghayur and Gilani, 2005).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Pharmacological studies on the laxative effects of Fagonia indica on rodents

Ali

Mehmood

Saleem

et al. 2019

Bangladesh J Pharmacol

View full text Add to dashboard Cite

This study explores the pharmacological basis for the folk use of Fagonia indica in constipation using in vivo and in vitro assays. The crude extract of F. indica contained tannins, saponins, anthraquinones, alkaloids, flavonoids, glycosides and phenols. The administration of F. indica extract (100 and 300 mg/kg) to mice caused a partially atropine-sensitive 35 and 42.6% laxation, respectively, similar to ursolic acid which showed 22 and 36% laxation at 10 and 30 mg/kg, respectively. In loperamide-induced constipation mice, F. indica (27.3 and 34.6%) and ursolic acid (15 and 28%) also displayed laxative effects at the aforementioned doses. In mice and rats ileum, F. indica, its fractions (ethyl acetate, aqueous) and ursolic acid produced atropine-sensitive stimulatory effects, while in rats ileum, F. indica and aqueous fraction showed partially atropine-sensitive effects. F. indica and ursolic acid possess laxative and species-specific gut stimulant effects predominantly involving the activation of muscarinic receptor, thus eliciting its folk use in constipation. Video Clip of Methodology: 7 min 7 sec: Full Screen Alternate

show abstract