“…Puoti et al. speculated that different hormonal factors, such as estrogens, could act as modulators of some mechanisms and may explain the differences between genders, 25 based on the decreased ALT levels in pregnant and estrogen‐treated females with chronic hepatitis C 31,32 . Indeed, in the present study, the aminotransferase levels in HCV positive females were independent of age; although these levels, especially ALT, were elevated in males aged less than 65 years.…”