EFFECT OF ETHIONINE ON THE CORTISONE-EVOKED STIMULATION OF TRYPTOPHAN PEROXIDASEOXIDASE ACTIVITY¹

The Action of Steroid Hormones at the Cellular Level

“…Tryptophan pyrrolase activity in liver is stimulated by the administration of hydrocortisone to rats but this increase is prevented by simultaneous administration of the methionine analogue ethionine (Horton and Franz, 1959); in perfused-liver preparations the increase occurs after the hydrocortisone has disappeared (Goldstein, Stella and Knox, 1962).…”

Effects of Cortisol on Amino Acids in Skeletal Muscle and Plasma

“…cocorticoids leads to increased protein content of the liver (1)(2)(3)(4)(5) and increased activity of several liver enzyme systems (6)(7)(8)(9). Thus, despite the over-all catabolic effects of glucocorticoids on protein metabolism of the organism (10)(11)(12), there is adequate evidence that these steroids promote anabolism of protein by the liver.…”

Tryptophan Pyrrolase Induction and the Influence of Adrenocorticoids1

“…Consequently, the induced formation of this enzyme system may be regarded as being under the influence of two agencies: the specific substrate and the adrenal secretory product. This relationship has been the object of extensive study and a number of reports (3,4,(6)(7)(8)(9)(10). Adrenalectomy has been consistently shown to result in a markedly diminished hepatic ability to form TP following injection of the amino acid; this observation has provided the opportunity to elucidate a part of the relationship stated above.…”