Effect of Etomidate on Pneumonia Development in Critically Ill, Nontrauma Patients

Abstract

Etomidate use was not associated with a difference in HAP development in critically ill, nontrauma patients.

Effect of Etomidate vs Propofol for Total Intravenous Anesthesia on Major Postoperative Complications in Older Patients

“…This finding is consistent with previous reports that single-dose etomidate is associated with a higher incidence of hospital-acquired pneumonia after cardiac surgery and that etomidate is an independent risk factor for hospital-acquired pneumonia in patients with trauma . However, another retrospective study in patients with critical illness reported no association between single-dose etomidate and pneumonia . Nonetheless, the collective evidence supports cautious use of etomidate infusion in patients at risk for pulmonary complications.…”

“…9 However, another retrospective study in patients with critical illness reported no association between single-dose etomidate and pneumonia. 8 Nonetheless, the collective evidence supports cautious use of etomidate infusion in patients at risk for pulmonary complications. Given the relevance of pulmonary complications for mortality in older patients after major surgery, this issue requires further study.…”

“…There were no significant between-group differences in the numbers of patients with PONV scores of 3 or higher or in pain scores at 6 hours, 1 day, or 3 days after surgery. On postoperative day 1, there was a significant difference between groups in median (IQR) patient comfort ratings (8 [7][8][9] vs 8 [7][8][9]; P = .008) but not in median (IQR) patient satisfaction with anesthesia ratings (Table 2; eTable 2 in Supplement 2).…”

“…In patients with trauma, 3 patients undergoing cardiac surgery, 4 and even patients with critical illness, 5,6 single-dose etomidate for induction of anesthesia showed no difference in mortality compared with other agents, whereas the influence of etomidate on morbidity, such as hospital-acquired pneumonia, remains controversial. 4,[7][8][9] Furthermore, because most studies have focused on bolus administration of etomidate for anesthesia induction, there is a lack of data on the effects of continuous infusion of etomidate for anesthesia maintenance on hemodynamics, adrenocortical suppression, and clinical outcomes.…”