Effect of Eurycoma Longifolia Jack Extract on Lipolysis in Collegiate Athletes: Pilot study

Lim, Pei Jean; Gan, Chye-Sheng; Khong, T. K.; Hamzah, Sareena Hanim; Yusof, Ashril

doi:10.1007/978-981-10-3737-5_20

Cited by 4 publications

(8 citation statements)

References 10 publications

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“…The study found that a standardized quassinoid-enriched fraction of E. longifolia reduced body weight gain, adipose tissue hypertrophy, and serum glycerol levels in mice with HFD induced obesity [16]. Furthermore, clinical testing illustrated that consumption of the E. longifolia extract together with exercise enhanced lipolysis [14]. Thus, in addition to being identified as a promising candidate in this study, E. longifolia has been proven effective for the treatment of obesity by several researchers.…”

Section: Discussionmentioning

confidence: 62%

“…Moreover, E. longifolia roots displayed low pancreatic lipase-inhibitory activity but strong potential to enhance lipolysis and reduce lipid accumulation in 3T3-L1 adipocytes. E. longifolia is a well-known medicinal plant in the Asian region, and several studies have described the potential of its roots to treat obesity [14][15][16]. For instance, our research group previously explored the bioactive compounds of E. longifolia roots and their lipolysis-enhancing activities in a cell-based assay [15].…”

Section: Discussionmentioning

confidence: 99%

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Selection of Thai Medicinal Plants with Anti-Obesogenic Potential via In Vitro Methods

Ruangaram

Kato

2020

Pharmaceuticals

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The prevalence of obesity is increasing globally. Despite the availability of a variety of anti-obesogenic drugs, including therapies under clinical development, these treatments are often indicated for patients with severe obesity, making them unsuitable for patients with mild obesity or for preventative use. In Thailand, traditional remedies employing medicinal plants are widely used to maintain health and treat disease. These treatments are generally inexpensive and readily available at markets, making them good treatment options for preventing obesity. To evaluate the anti-obesogenic potential of Thai medicinal plants, we employed three in vitro methods: pancreatic lipase inhibition, lipolysis enhancement, and lipid accumulation reduction assays. Among 70 Thai medicinal plants, Eurycoma longifolia Jack, Tiliacora triandra Diels, and Acacia concinna (Willd.) DC. were selected as the most favorable candidates because they exhibited anti-obesogenic activity in all three assays. These medicinal plants are expected to have efficient anti-obesogenic effects, making them promising candidates for further study.

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Section: Discussionmentioning

confidence: 62%

Section: Discussionmentioning

confidence: 99%

Selection of Thai Medicinal Plants with Anti-Obesogenic Potential via In Vitro Methods

Ruangaram

Kato

2020

Pharmaceuticals

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“…In healthy male recreational athletes, E. longifolia at the dose of 150 mg daily for 7 days showed no beneficial effects on endurance running performance [132] . In male athletes, E. longifolia ingested at the dose of 1.7 mg/kg body weight per day showed ergogenic benefits: induction of lipolysis, improvement in exercise performance, and enhancement of energy production [133] . E. longifolia has been proven to decrease cortisol levels and increase testosterone concentration in saliva of volunteers [134] …”

Section: Ingredients Permitted (Or Not Specified) By Wadamentioning

confidence: 99%

Risk Associated with the Use of Selected Ingredients in Food Supplements

Jędrejko

Lazur

Muszyńska

2021

Chemistry & Biodiversity

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This review focuses on four new product categories of food supplements: pre‐workout, fat burner/thermogenic, brain/cognitive booster, and hormone/testosterone booster. Many food supplements have been shown to be contaminated with unauthorized substances. In some cases, the ingredients in the new categories of dietary supplements were medicinal products or new synthetic compounds added without performing clinical trials. Some of the new ingredients in dietary supplements are plant materials that are registered in the pharmacopoeia as herbal medicines. In other cases, dietary supplements may contain plant materials that have no history of human use and are often used as materials to ‘camouflage’ stimulants. In the European Union, new ingredients of dietary supplements, according to European Food Safety Authority or unauthorized novel food. Furthermore, selected ingredients in dietary supplements may be prohibited in sports and are recognized as doping agents by World Anti‐Doping Agency.

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“…Characteristics of the included studies (n = 9) are reported in Table 1. There were three studies that investigated a male population affected by hypogonadism [26][27][28], while six studies included a population of healthy men with normal testosterone levels [29][30][31][32][33][34]. E. longifolia was investigated primarily as a commercial water-extracted product (Physta ® , Biotropics, Berhad, Kuala Lumpur, Malaysia) in seven of the nine studies included [26,27,[29][30][31][32][33], with variable dosages from 100 to 600 mg/daily for a minimum of 3 days to a maximum of 6 months (Table 1).…”

Section: Systematic Reviewmentioning

confidence: 99%

“…Most of the studies (n = 7) reported a significant improvement in total testosterone levels after E. longifolia treatment [26][27][28][29][30]33,34]. However, two studies failed to observe any improvement in testosterone levels when the treatment was stopped after 3 weeks [30] or prolonged to 8 weeks [34].…”

Section: Systematic Reviewmentioning

confidence: 99%

Eurycoma longifolia (Jack) Improves Serum Total Testosterone in Men: A Systematic Review and Meta-Analysis of Clinical Trials

Leisegang¹,

Finelli

Sikka

et al. 2022

Medicina

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Background and Objectives: Male hypogonadism is a clinical disorder characterized by reduced serum testosterone in men. Although treatment using herbal medicines, including Eurycoma longifolia, has been investigated, the benefits remain unclear. This study aims to investigate the efficacy of E. longifolia as a sole intervention to increase testosterone levels in males. Materials and Methods: We conducted a systematic review and meta-analysis of randomized clinical trials (RCTs) according to the PRISMA guidelines. Relevant articles were retrieved from the databases PubMed, Scopus, Web of Science, Cochrane, Ovid/Embase, and Google Scholar. Results: After literature screening, a total of nine studies was included in the systematic review. Five RCTs were included in the meta-analysis. A significant improvement in total testosterone levels after E. longifolia treatment was mostly reported in both healthy volunteers and hypogonadal men. The random model effect revealed a significant increase (SMD = 1.352, 95% CI 0.565 to 2.138, p = 0.001) in the total testosterone levels in men receiving E. longifolia supplementation, which was confirmed in the hypogonadism subgroup. Conclusions: This systematic review and meta-analysis of the literature supports the possible use of E. longifolia supplementation for enhancing testosterone production. Although more research is required before its use in clinical practice, this may represent a safe and promising therapeutic option, particularly in hypogonadal men.

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Effect of Eurycoma Longifolia Jack Extract on Lipolysis in Collegiate Athletes: Pilot study

Cited by 4 publications

References 10 publications

Selection of Thai Medicinal Plants with Anti-Obesogenic Potential via In Vitro Methods

Selection of Thai Medicinal Plants with Anti-Obesogenic Potential via In Vitro Methods

Risk Associated with the Use of Selected Ingredients in Food Supplements

Eurycoma longifolia (Jack) Improves Serum Total Testosterone in Men: A Systematic Review and Meta-Analysis of Clinical Trials

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