Effect of Evening Primrose Oil on Platelet Aggregation in Rabbits Fed an Atherogenic Diet

Cruz, J. P. De La; Martin-Romero, Mercedes; Carmona, José Antonio; Villalobos, M.A.; Cuesta, Felipe Sánchez de la

doi:10.1016/s0049-3848(97)00113-8

Cited by 22 publications

(15 citation statements)

References 14 publications

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“…# P < 0.05; ## P < 0.001, with respect to reoxygenated slices in the control group (n = 15 rats per group) this parameter. Researchers who have investigated the effect of different types of oil and their components on the glutathione system mostly concur that changes in this system are not dependent on the fatty acid composition of the oil, but rather on non-glyceride components, especially vitamin E and polyphenols [27,[35][36][37][38]. We found no reports of this effect in the model of brain ischemia-reperfusion we used.…”

Section: Discussionmentioning

confidence: 71%

Dietary Virgin Olive Oil Reduces Oxidative Stress and Cellular Damage in Rat Brain Slices Subjected to Hypoxia–Reoxygenation

Correa

Muñoz‐Marín

Arrebola³

et al. 2007

Lipids

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We investigated how virgin olive oil (VOO) affected platelet and hypoxic brain damage in rats. Rats were given VOO orally for 30 days at 0.25 or 0.5 mL kg(-1) per day (doses A and B, respectively). Platelet aggregation, thromboxane B2, 6-keto-PGF(1alpha), and nitrites + nitrates were measured, and hypoxic damage was evaluated in a hypoxia-reoxygenation assay with fresh brain slices. Oxidative stress, prostaglandin E2, nitric oxide pathway activity and lactate dehydrogenase (LDH) activity were also measured. Dose A inhibited platelet aggregation by 36% and thromboxane B2 by 19%; inhibition by dose B was 47 and 23%, respectively. Virgin olive oil inhibited the reoxygenation-induced increase in lipid peroxidation (57% in control rats vs. 2.5% (P < 0.05) in treated rats), and reduced the decrease in glutathione concentration from 67 to 24% (dose A) and 41% (dose B). Brain prostaglandin E2 after reoxygenation was 306% higher in control animals, but the increases in treated rats were only 53% (dose A) and 45% (dose B). The increases in nitric oxide production (213% in controls) and activity of the inducible isoform of nitric oxide synthase (175% in controls) were both smaller in animals given VOO (dose A 84%; dose B 12%). Lactate dehydrogenase activity was reduced by 17% (dose A) and 42% (dose B). In conclusion, VOO modified processes related to thrombogenesis and brain ischemia. It reduced oxidative stress and modulated the inducible isoform of nitric oxide synthase, diminishing platelet aggregation and protecting the brain from the effects of hypoxia-reoxygenation.

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Section: Discussionmentioning

confidence: 71%

Dietary Virgin Olive Oil Reduces Oxidative Stress and Cellular Damage in Rat Brain Slices Subjected to Hypoxia–Reoxygenation

Correa

Muñoz‐Marín

Arrebola³

et al. 2007

Lipids

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“…In addition, herbs preclinically evidenced to affect pharmacokinetics of warfarin (Andrographis [140–143], Horse chestnut [63, 82], Schisandra [144–146], Gegen [147–149], and Liquorice [150, 151]) and pharmacodynamics of warfarin ( Clove [40, 152, 153], Lapacho [32, 154]), or both ( Evening primrose [70, 155], Feverfew [60, 107, 156]); herbs containing vitamin K (Alfalfa [40, 157, 158], Asparagus [40, 159]) or coumarin ( Bogbean [18, 40], Celery [160, 161], and Horse chestnut [40]) and herbs with similar or opposite pharmacological actions to those of warfarin may also interact with warfarin. As no clinical evidence is now available to support an interaction, these herbs were defined as doubtful in the current review.…”

Section: Resultsmentioning

confidence: 99%

Updates on the Clinical Evidenced Herb‐Warfarin Interactions

Zhang

Zuo

2014

Evidence-Based Complementary and Alternative Medicine

103

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Increasing and inadvertent use of herbs makes herb-drug interactions a focus of research. Concomitant use of warfarin, a highly efficacious oral anticoagulant, and herbs causes major safety concerns due to the narrow therapeutic window of warfarin. This paper presents an update overview of clinical findings regarding herb-warfarin interaction, highlighting clinical outcomes, severity of documented interactions, and quality of clinical evidence. Among thirty-eight herbs, Cannabis, Chamomile, Cranberry, Garlic, Ginkgo, Grapefruit, Lycium, Red clover, and St. John's wort were evaluated to have major severity interaction with warfarin. Herbs were also classified on account of the likelihood of their supporting evidences for interaction. Four herbs were considered as highly probable to interact with warfarin (level I), three were estimated as probable (level II), and ten and twenty-one were possible (level III) and doubtful (level IV), respectively. The general mechanism of herb-warfarin interaction almost remains unknown, yet several pharmacokinetic and pharmacodynamic factors were estimated to influence the effectiveness of warfarin. Based on limited literature and information reported, we identified corresponding mechanisms of interactions for a small amount of “interacting herbs.” In summary, herb-warfarin interaction, especially the clinical effects of herbs on warfarin therapy should be further investigated through multicenter studies with larger sample sizes.

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“…Similarly, Syzygium aromaticum essential oil significantly improved dyslipidemia by reducing plasma TC, TG, and LDL-C levels and by increasing plasma HDL-C levels in rats with metabolic syndrome induced by a high fructose diet [4]. Supplementation of a hyperlipemic diet with Oenothera biennis essential oil reduced plasma TG and TC levels and increased plasma HDL-C levels [43,44], and intake of Linum usitatissimum L. essential oil reduced blood TC, TG, and LDL-C levels, in patients diagnosed with metabolic syndrome [34].…”

Section: Dyslipidemiamentioning

confidence: 99%

“…For example, Citrus bergamia Risso essential oil reduced MDA production in carotid arteries injured by balloon angioplasty [23] and Nigella sativa essential oil reduced plasma MDA formation in hyperlipidemic rats [39]. In rabbits, an atherogenic diet supplemented with Oenothera biennis essential oil inhibited platelet MDA production [44]. Oral administration of Syzygium aromaticum essential oil to rats with metabolic syndrome reduced plasma MDA concentrations [4].…”

Section: Oxidative Stressmentioning

confidence: 99%

Essential Oils and Factors Related to Cardiovascular Diseases

Seol¹,

Shin²

2018

Potential of Essential Oils

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Cardiovascular diseases (CVDs) are the leading cause of mortality and a major economic burden worldwide. Various drugs, including antihypertensive, antihyperlipidemic, and antiplatelet agents, are prescribed to treat CVDs, but these agents have side effects, including serious side effects such as bleeding. Therefore, efforts are being made to develop new drugs made of natural substances with relatively weak side effects. Essential oils are natural substances extracted from aromatic plants with biological effects, such as antioxidant and antiinflammatory activities. These oils have therefore long been used in traditional medicines. This chapter reviews the effects of essential oils on CVD-related factors. Essential oils have various effects, including improvements in lipid balance, liver function, and endothelial function; reductions in blood pressure, oxidative stress, thrombosis, and inflammation; promotion of vascular relaxation; and inhibition of diabetes development and angiogenesis. Therefore, essential oils and their active components may be promising therapeutic agents for CVDs. Further studies are needed to clarify their clinical effects and to elucidate their specific mechanisms of activity.

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Effect of Evening Primrose Oil on Platelet Aggregation in Rabbits Fed an Atherogenic Diet

Cited by 22 publications

References 14 publications

Dietary Virgin Olive Oil Reduces Oxidative Stress and Cellular Damage in Rat Brain Slices Subjected to Hypoxia–Reoxygenation

Dietary Virgin Olive Oil Reduces Oxidative Stress and Cellular Damage in Rat Brain Slices Subjected to Hypoxia–Reoxygenation

Updates on the Clinical Evidenced Herb‐Warfarin Interactions

Essential Oils and Factors Related to Cardiovascular Diseases

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