Effect of excess dietary cystine on the biodynamics of cholesterol in the rat

Lipid Accumulation in the Liver of Rats Fed a Soy Protein Isolate Diet with Excess Cystine, and its Prevention by Methionine or Choline

“…Hypercholesterolemia was observed after feeding the test diets for 6 days even when a large amount of cystine (3.5%) was added (Tables IV and VI). Cholesterol was also accumulated in the liver according to the report of Rukaj and Serougne 4 ) as well as the data in this report (Table III). Liver cholesterol increased in rats fed a 3.5% cystine-excess diet when expressed as mg per liver per 100 g body weight (not shown in table).…”

Effects of Adding Some Dietary Fibers to a Cystine Diet on the Activities of Liver Antioxidant Enzymes and Serum Enzymes in Rats

“…[1][2][3] Furthermore, among 18 individual L-amino acids tested, cystine is one of the most severely toxic. 4) Excess dietary cystine has caused hypercholesterolemia in rats after feeding for 2-4 months [5][6][7][8] due to increased cholesterogenesis in the liver. [6][7][8] The elevation in serum cholesterol by this diet was observed within 7 d of starting feeding, [9][10][11][12][13] and the hypercholesterolemia could be prevented by the addition of some dietarŷ bers.…”

“…4) Excess dietary cystine has caused hypercholesterolemia in rats after feeding for 2-4 months [5][6][7][8] due to increased cholesterogenesis in the liver. [6][7][8] The elevation in serum cholesterol by this diet was observed within 7 d of starting feeding, [9][10][11][12][13] and the hypercholesterolemia could be prevented by the addition of some dietarŷ bers. 9,10) Although the activities of aspartate aminotransferase (EC 2.6.1.1) and alanine aminotransferase (EC 2.6.1.2) in the serum have been found to be a useful indicator of liver damage in the diagnosis and study of acute hepatic disease, 14,15) these enzymes are located not only in the liver, but also in the extrahepatic tissues.…”

“…[5][6][7][8][9][10][11][12][13] The elevation in the activity of either alanine aminotransferase or aspartate aminotransferase in the serum is often useful as an index of liver cell damage. Furthermore, serum alanine aminotransferase might be a more speciˆc index of liver cell damage than aspartate aminotransferase because of its selective concentration in the liver tissue.…”

Metabolism of cholesterol and triglycerides in young pigs fed beef-based, soy-based, or conventional diets

“…Each of these studies demonstrated that the cholesterolemic effect of the test protein was not altered by the supplementation of lysine or arginine. Other experiments have found effects of supplementation of methionine (reviewed by Terpstra et al, 1983b), cystine (reviewed by Terpstra et al, 1983b; see also Rukaj and Sérougne, 1983;Sérougne and Rukaj, 1983), tryptophan (Sérougne and Rukaj, 1983), glycine (Katan et al, 1982), and glutamic acid and histidine (also discussed by Terpstra et al, 1983b). In summary, the amino acid when rats and rabbits were fed soy protein rather than casein.…”