Effect of excess leucine in low protein diet on ketosis in 3-week-old male broiler chicks fed different levels of isoleucine and valine

Farran, M. T.; Barbour, E. K.; Ashkarian, V. M.

doi:10.1016/s0377-8401(02)00289-4

Cited by 17 publications

(14 citation statements)

References 15 publications

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“…The values proposed by BNN for isoleucine are closer to previously recommended values of 12 and 13.6 g kg (1 of diet (NRC 1994;Farran et al 2003).…”

Section: Resultssupporting

confidence: 78%

“…To address the objectives of this study, 270 lines of broiler chick dose responses (ADG and FE) to protein and BCAA were extracted from the literature, comprising experiments conducted during 1990Á2013 Thomas 1990, 1992;Barbour and Latshaw 1992;Burnham et al 1992;Waldroup et al 2002;Farran et al 2003;Yamazaki et al 2006;Tavernari et al 2013). The dietary levels of protein, isoleucine, leucine, and valine (g kg (1 of diet) were considered as input variables, while ADG and FE were the variables of interest for model output.…”

Section: Materials and Methods Data Sourcementioning

confidence: 99%

“…One problem with the data cleaving is that model performance of a NN model can heavily depend on the partitioning of the available data, especially when the available data set is small (Maier and Dandy 2000). To circumvent this Thomas (1990, 1992), Barbour and Latshaw (1992), Burnham et al (1992), Waldroup et al (2002), Farran et al (2003), Yamazaki et al (2006), and Tavernari et al (2013).…”

Section: Bootstrapped Neural Network Model Developmentmentioning

confidence: 99%

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Bootstrapped neural network models for analyzing the responses of broiler chicks to dietary protein and branched chain amino acids

et al. 2014

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, J. 2014. Bootstrapped neural network models for analyzing the responses of broiler chicks to dietary protein and branched chain amino acids. Can. J. Anim. Sci. 94: 79Á85. Reliable prediction of avian responses to dietary nutrients is essential for planning, management, and optimization activities in poultry nutrition. In this study, two bootstrapped neural network (BNN) models, each containing 100 separated neural networks (SNN), were developed for predicting average daily gain (ADG) and feed efficiency (FE) of broiler chicks in response to intake of protein and branched chain amino acids (BCAA) in the starter period. Using a re-sampling method, 100 different batches of data were generated for both the ADG and FE sets. Starting with 270 data lines extracted from eight studies in the literature, SNN models were trained, tested, and validated with 136, 67, and 67 data lines, respectively. All 200 SNN models developed, along with their respective BNN ones, were subjected to optimization (to find the optimum dietary protein and BCAA levels that maximize ADG and FE). Statistical analysis indicated that based on R 2 , the BNN models were more accurate in 76 and 56 cases (out of 100) compared with the SNN models developed for ADG and FE, respectively. Optimization of the BNN models showed protein, isoleucine, leucine, and valine requirements for maximum ADG were 231.80, 9.05, 14.03 and 10.90 g kg(1 of diet, respectively. Also, maximum FE was obtained when the diet contained 232.30, 9.07, 14.50, and 11.04 g kg(1 of protein, isoleucine, leucine, and valine, respectively. The results of this study suggest that in meta-analytic modelling, bootstrap re-sampling algorithms should be used to better analyze available data and thereby take full advantage of them. This issue is of importance in the animal sciences as producing reliable data is both expensive and time-consuming.Key words: Branched chain amino acids, broiler responses, neural networks, bootstrapping Faridi, A., Golian, A., Heravi Mousavi, A. et France, J. 2014. Mode`les de re´seaux neuronaux a`ve´rifications de type « bootstrap » pour l'analyse des re´ponses aux prote´ines alimentaires et aux acides amine´s a`chaıˆnes ramifie´es chez les jeunes poulets a`griller. Can. J. Anim. Sci. 94: 79Á85. La pre´diction fiable des re´ponses aviaires aux e´le´ments nutritifs est essentielle pour la planification, la gestion et l'optimisation des activite´s nutritionnelles de la volaille. Dans cette e´tude, deux mode`les de re´seaux neuronaux a`ve´rifications de type « bootstrap » (BNN Á « bootstrapped neural network »), chacun contenant 100 re´seaux neuronaux se´pare´s (SNN Á « separated neural networks »), ont e´te´de´veloppe´s pour la pre´diction des gains moyens quotidiens (ADG Á « average daily gain ») et de l'efficience alimentaire (FE Á « feed efficiency ») chez les jeunes poulets a`griller en re´ponse a`l'ingestion de prote´ines et d'acides amine´s à chaıˆnes ramifie´es (BCAA Á « branched chain amino acids ») dans la pe´riode de de´but. En utilisant une me´thode de re´...

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“…The values proposed by BNN for isoleucine are closer to previously recommended values of 12 and 13.6 g kg (1 of diet (NRC 1994;Farran et al 2003).…”

Section: Resultssupporting

confidence: 78%

Section: Materials and Methods Data Sourcementioning

confidence: 99%

Section: Bootstrapped Neural Network Model Developmentmentioning

confidence: 99%

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Bootstrapped neural network models for analyzing the responses of broiler chicks to dietary protein and branched chain amino acids

et al. 2014

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“…However, studies evaluating the additions of L-leucine to low CP diets failed to show the same growth performance as those fed the recommended CP levels in broiler grower chickens. Other studies also reported that supplementation of non-essential amino acids to low CP diets have been unable to show equal growth performance of broiler fed control diets [1,4,[10][11][12]19,24,25] . There were no significant difference on abdominal fat, gizzard, liver and heart due to level of protein.…”

Section: Discussionmentioning

confidence: 99%

Effect of L-Leucine Supplementation on Growth Performance and Carcass Characteristics of Grower-Broiler Chickens Fed Low Protein Diets

Erwan¹,

Alimon²,

Sazili³

et al. 2009

American J. of Animal and Veterinary Sciences

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Problem statement: Supplementation of broiler diets with cristalline amino acids (i.e. lysine, ethionine and threonine) may support equal broiler growth and improve overall amino acids balance and enable a reduction in CP level of diets. Approach: A trial was conducted to evaluate the effect of supplemental L-leucine in diets containing recommended levels and low crude protein (20 and 18%, respectively) with constant metabolizable energy (3200 kcal kg −1 ) for broilers from 21-42 day of age. Six experimental diets were formulated with three levels of supplemental L-leucine, 0, 0.5 and 0.67% and two levels of crude protein. A total of 180 1 day-old Cobb broiler chickens were randomly divided into 36 experimental pens, 5 chickens in each pen, with each diet replicated 6 times. The dietary treatments were offered from 21-42 days of age. Feed intake, body weight gain and Feed Conversion Ratio (FCR) were measured on a weekly basis. At the end of the feeding trial the birds were slaughtered and carcass analyses conducted. Results: Feed intake, weight gain and FCR were not affected by increasing levels of L-leucine supplementation. Weight gain was significantly reduced (p<0.05), whereas feed intake and FCR were not significantly affected with decreasing dietary crude protein. A positive response in breast meat yield was achieved by the addition of L-leucine to levels up to 0.5% in the diet but a significant decrease was noted when the level reached 0.67% in diet. Supplementation of L-leucine significantly (p<0.05) decreased the relative weights of the liver and gizzard. However, the addition of L-leucine significantly reduced carcass weights when L-leucine was added at 0.67%. Lowering the dietary protein level also significantly reduced breast yield and carcass weight (p<0.05). However, abdominal fat, gizzard, liver and heart were not affected by protein level. Conclusion/Recommendations: It can be concluded that supplementation of L-leucine at levels up to 0.67% of the diet did not affect performance but deleteratious the carcass weight.

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“…Leucine appears to antagonize other BCAA, since the excess reduces the concentrations of valine, isoleucine and its keto acids in plasma and tissues (TANNOUS et al, 1966;. Different researches developed with rats (TORRES et al, 1995), poultry (CALVERT et al, 1982;FARRAN et al, 2002) and pigs WILTAFSKY et al, 2010) reported negative responses in average daily gain (ADG) and a reduced feed intake in response an excess of dietary leucine.…”

Section: Introductionmentioning

confidence: 99%

Leucine levels in low protein diets for pigs in the initial phase

Huepa

Fachinello

Esteves

et al. 2017

SCA

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The objective of this study was to evaluate the standardized ileal digestible (SID) leucine levels in low crude protein diets on Performance, backfat thickness, longissimus dorsi depth and biochemical blood parameters of starting pigs. A total of 50 pigs, with initial weight of 11.14±0.24 kg; were distributed in a randomized blocks design with five treatments (1.10; 1.25; 1.40; 1.55 and 1.70% SID leucine), five replicates and two animals per experimental unit, comprised for a barrow and a gilt. The feed conversion ratio (FCR) reduced (P=0.018) due to the increasing SID leucine levels, without affecting other growth performance parameters (final weight, average daily feed intake, average daily gain, backfat thickness, longissimus dorsi depth and lean meat percentage). There was a quadratic effect for plasma triglyceride (P=0.049) and plasma urea (P=0.001). The optimal SID leucine levels obtained for triglycerides and urea were 1.16% and 1.24%, respectively, by associating the quadratic model with the Linear Response Plateu. Low crude protein diets with SID leucine levels up to 1.70% improved the feed conversion with desired urea and triglycerides concentration in blood plasma achieved at 1.16% and 1.24%, respectively.

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Effect of excess leucine in low protein diet on ketosis in 3-week-old male broiler chicks fed different levels of isoleucine and valine

Cited by 17 publications

References 15 publications

Bootstrapped neural network models for analyzing the responses of broiler chicks to dietary protein and branched chain amino acids

Bootstrapped neural network models for analyzing the responses of broiler chicks to dietary protein and branched chain amino acids

Effect of L-Leucine Supplementation on Growth Performance and Carcass Characteristics of Grower-Broiler Chickens Fed Low Protein Diets

Leucine levels in low protein diets for pigs in the initial phase

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