Effect of exercise and high-fat diet on plasma adiponectin and nesfatin levels in mice

Abstract

Abstract. lifestyle-related diseases are associated with overeating and lack of exercise. the purpose of this study was to investigate the effect of exercise and high-fat diet on plasma adiponectin and nesfatin levels. mice were housed for 4 weeks in 4 groups, which included the non-exercise and normal diet (Sn), exercise and normal diet (En), non-exercise and high-fat diet (SF) and the exercise and high-fat diet (EF) group. the mice in the exercise groups were housed in cages with a running wheel and were subjected to voluntary exercise. the food intake (Kcal) of the mice in the exercise groups increased compared to that of the mice in the non-exercise groups (p<0.01). Body weight and visceral fat decreased in the mice in the EF group compared to the mice in the SF group (p<0.01 and p<0.05). the temperature of the mice in the EF group increased compared to that of the mice in the Sn group (p<0.05). Blood glucose, insulin (p<0.01), cholesterol (p<0.01) and triglyceride concentrations (p<0.01) increased in the SF group compared to the normal diet groups. Furthermore, plasma insulin and cholesterol concentrations increased in the SF group compared to the exercise groups (p<0.01). plasma adiponectin and nesfatin-1 levels in the SF group decreased compared to the Sn group (p<0.05). Exercise under a high-fat diet antagonized the significant decrease in the nesfatin-1 level. Exercise together with a high-fat diet affected the plasma levels of adiponectin and nesfatin. it is therefore suggested that exercise together with a high-fat diet can affect various diseases via adiponectin and nesfatin.

Moderate exercise training has anorexogenic effect associated with improved oxidative stress in obese women

“…This finding came along with the responses to appetite questionnaires which indicated less desire to eat, less perceived hunger, less craving for carbohydrates and lower scores on "how much food can you eat" questions. These findings are in agreement with the results of Chaolu et al (2011) who showed that four weeks of endurance training increased plasma nesfatin-1 level. Shimizu et al (2009) found that the intraperitoneal administration of nesfatin-1 inhibits food intake and thereby reduces body weight (Shimizu et al, 2009).…”

Effects of endurance training and herb supplementation on tissue nesfatin-1/nucleobindin-2 and ghrelin mRNA expression

“…Our data are consistent with those studies who's investigated the effects of different mode acute/ chronic exercise training on plasma nesfatin-1 in human and animal subjects [69][70][71][72]. In our study, we observed a lower ghrelin mRNA expression in both saline and Bane-trained liver, not in visceral fat tissue.…”

The effects of short-term high-intensity interval training vs. moderate-intensity continuous training on plasma levels of nesfatin-1 and inflammatory markers

“…However, to our knowledge, the capacity of different exercise training programs to alter nesfatin has yet to be fully investigated. Only few studies have investigated the effects of short-term ( < 20 min) acute exercises (including human study) [17] or exercise training and diet on nesfatin-1, which has been carried out in mice [18,19] . Physical exercise is an essential part of any weight management program and an effective method to reduce the risk of insulin resistance and chronic inflammation.…”