Effect of Exercise on Blood-Lipids in Juvenile Diabetes

Larsson, Yngve; Persson, Bengt; Sterky, G; Thorén, Claes

doi:10.1016/s0140-6736(64)92098-7

Cited by 21 publications

(14 citation statements)

References 28 publications

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“…In type I diabetics, a tendency toward a reduction in total cholesterol has been reported after physical training. 40 Our data in fact demonstrated a significant fall in the total plasma cholesterol level, accompanied by an increase in the relative component of HDL cholesterol. The fall in the total level is presumably an effect of the physical training per se, since we could not demonstrate any improvement in glucose control, which in other studies has been shown to affect plasma cholesterol levels.…”

Section: Discussionsupporting

confidence: 48%

Increased Peripheral Insulin Sensitivity and Muscle Mitochondrial Enzymes but Unchanged Blood Glucose Control in Type I Diabetics After Physical Training

et al. 1982

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Nine male, insulin-dependent diabetic patients participated in a 16-wk training program consisting of 1 h of jogging, running, ball games, and gymnastics, performed 2-3 times/wk. The training resulted in an 8% increase of maximal oxygen uptake (P less than 0.01). Insulin sensitivity as determined by the insulin clamp technique increased 20% (P less than 0.05). Glycosylated hemoglobin showed no change (10.4 +/- 0.7% versus 11.3 +/- 0.5%), 24-h urinary glucose excretion was not reduced, and home-monitored urine tests were unchanged. The frequency of hypoglycemic attacks did not change during the training period and body weight remained constant. There was a 14% fall in plasma cholesterol (P less than 0.01) and a rise in the proportion of HDL-cholesterol from 24 +/- 2% to 30 +/- 3% (P less than 0.01). Thigh muscle oxidative capacity increased, as indicated by a 24% increase in succinate dehydrogenase activity (P less than 0.05). The number of capillaries/muscle fiber increased 15% (P less than 0.01). However, as the mean muscle fiber cross-sectional area increased to a similar extent (11%, P less than 0.05), capillary density (cap x mm-2) was unchanged. In conclusion, this study demonstrates that physical training in insulin-dependent diabetics results in increased peripheral insulin sensitivity, a rise in muscle mitochondrial enzyme activities, decreased total plasma cholesterol levels, and unchanged blood glucose control. The findings suggest that in the absence of efforts to alter dietary regulation and insulin administration, physical training consisting of 2-3 weekly bouts of moderate exercise may not of itself improve blood glucose control in type I diabetes.

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Section: Discussionsupporting

confidence: 48%

Increased Peripheral Insulin Sensitivity and Muscle Mitochondrial Enzymes but Unchanged Blood Glucose Control in Type I Diabetics After Physical Training

et al. 1982

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“…Interventions were aerobic or a combination of aerobic and strengthening activity . Single aerobic exercises included running and walking , swimming and dance .…”

Section: Resultsmentioning

confidence: 99%

“…The studies by Larsson et al . were rated as having a high risk of selection bias because of unrepresentative intervention and control group samples (i.e. boys with an interest in sport and their friends who became the control group; Table S4).…”

Section: Resultsmentioning

confidence: 99%

Physical activity interventions in children and young people with Type 1 diabetes mellitus: a systematic review with meta‐analysis

et al. 2014

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AimsTo synthesize evidence from randomized and non-randomized studies of physical activity interventions in children and young people with Type 1 diabetes so as to explore clinically relevant health outcomes and inform the promotion of physical activity.MethodWe conducted a search of CINAHL Plus, the Cochrane Library, EMBASE, MEDLINE, PsycINFO, SCOPUS, SportDiscus and Web of Science between October and December 2012. Eligible articles included subjects aged ≤18 years with Type 1 diabetes and a physical activity intervention that was more than a one-off activity session. Physiological, psychological, behavioural or social outcomes were those of interest.ResultsA total of 26 articles (10 randomized and 16 non-randomized studies), published in the period 1964–2012, were reviewed. Although there was heterogeneity in study design, methods and reporting, 23 articles reported at least one significant beneficial health outcome at follow-up. Meta-analyses of these studies showed potential benefits of physical activity on HbA1c (11 studies, 345 participants, standardized mean difference -0.52, 95% CI -0.97 to -0.07; P = 0.02), BMI (four studies, 195 participants, standardized mean difference -0.41, 95% CI -0.70 to -0.12; P = 0.006) and triglycerides (five studies, 206 participants, standardized mean difference -0.70, 95% CI -1.25 to -0.14; P = 0.01).The largest effect size was for total cholesterol (five studies, 206 participants, standardized mean difference -0.91, 95% CI -1.66 to -0.17; P = 0.02).ConclusionsPhysical activity is important for diabetes management and has the potential to delay cardiovascular disease, but there is a lack of studies that are underpinned by psychological behaviour change theory, promoting sustained physical activity and exploring psychological outcomes. There remains a lack of knowledge of how to promote physical activity in people with Type 1 diabetes.

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“…Training programmes revealed a tendency to decrease the serum cholesterol levels, but dietary data -especially type and quantity of fat consumed -are not always given in detail (Rochelle [16]; Naugliton and Balke [15]; Lars son, Persson, Sterky and Thoren [12]. Kohn [11] found no effect on the serum cholesterol level of increasing physical acti vity.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Increasing the Daily Physical Activity on the Serum Cholesterol Levels

Dalderup¹,

Voogd²,

Meyknecht³

et al. 1967

Ann Nutr Metab

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Effect of Exercise on Blood-Lipids in Juvenile Diabetes

Cited by 21 publications

References 28 publications

Increased Peripheral Insulin Sensitivity and Muscle Mitochondrial Enzymes but Unchanged Blood Glucose Control in Type I Diabetics After Physical Training

Increased Peripheral Insulin Sensitivity and Muscle Mitochondrial Enzymes but Unchanged Blood Glucose Control in Type I Diabetics After Physical Training

Physical activity interventions in children and young people with Type 1 diabetes mellitus: a systematic review with meta‐analysis

The Effects of Increasing the Daily Physical Activity on the Serum Cholesterol Levels

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