Effect of Exercise on Cardiovascular Fitness and Quality of Life Outcomes in Advanced Breast Cancer Patients

Oliveira, Eugénio; Soares, José Maria; Seabra, André; Magalhaes, Sofia; Oliveira, Sara de Souza; Carvalho, Diana M.; Cardoso, Maria João

doi:10.1016/s0960-9776(17)30754-3

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“…Evidence suggests beneficial effects of the following methods, which can, therefore, be used: (i) physical exercise/sport (equivalent to 3-5 hours of moderate walking per week) improves cardiorespiratory fitness, physical performance and fatigue, and it may also improve DFS and OS in breast cancer patients; additionally, a supervised and individualised exercise results in an improvement in functional ability and QoL functions in women with ABC [72] [IV/B]; (ii) mindfulness-based stress reduction (MBSR) programmes, hypnosis and yoga may improve QoL and fatigue, improve sleep and help reduce anxiety, distress and some side effects of anticancer therapies; and (iii) acupuncture may help against ChT-induced nausea and vomiting, fatigue and hot flashes [70,73].…”

Section: Expert Opinion/ C 100%mentioning

confidence: 99%

4th ESO–ESMO International Consensus Guidelines for Advanced Breast Cancer (ABC 4)

et al. 2018

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Breast Cancer (ABC) comprises both locally advanced breast cancer (LABC) and metastatic breast cancer (MBC) [1]. Although treatable, MBC remains virtually an incurable disease with a median overall survival (OS) of $3 years and a 5-year survival of only $25% [2, 3]. The MBC Decade Report [2] shows that progress has been slow in terms of improved outcomes, quality of life (QoL), awareness and information regarding ABC. More recently, some studies seem to indicate an improvement in OS, mostly due to advances in human epidermal growth factor receptor 2 (HER2)-positive ABC [4][5][6]. The better survival is seen in an environment with access to the best available care and particularly in de novo ABC, while recurrent ABC seems to become harder to manage [7,8].The last decade has seen an improvement in the levels of evidence (LoEs) used for many of the ABC recommendations, however, still far from the LoEs existing for the majority of early

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Section: Expert Opinion/ C 100%mentioning

confidence: 99%