Effect of exercise on cognitive function in chronic disease patients: a meta-analysis and systematic review of randomized controlled trials

Cai, Hong; Li, Guichen; Hua, Shanshan; Liu, Yuanyuan; Chen, Li

doi:10.2147/cia.s135700

Cited by 54 publications

(41 citation statements)

References 62 publications

(243 reference statements)

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“…This was probably due to lack of physical activity, which is consistent with previous studies showing that physical activity positively influences cognitive functioning. 28,29) Concomitant use of anxiolytics and hypnotics was significantly associated with less improvement in subjective cognitive symptoms according to the PDQ-K total and attention/concentration scores. Previous studies have found that extensive and prolonged use of benzodiazepines produce cognitive impairment.…”

Section: Discussionmentioning

confidence: 98%

Predictors of Cognitive Improvement during 12 Weeks of Antidepressant Treatment in Patients with Major Depressive Disorder

Lee

Kim

Kang

et al. 2018

Clin Psychopharmacol Neurosci

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Objective: Cognitive disturbance is one of the major symptoms of depression and may be improved by treatment with antidepressants. This study aimed to investigate the predictors of cognitive improvement in patients with major depressive disorder (MDD) who were taking antidepressants. Methods: This study included 86 patients with MDD who completed 12 weeks of antidepressant monotherapy. Cognitive symptoms were assessed using the Perceived Deficits Questionnaire-Korean version (PDQ-K), which addresses four domains of cognitive functioning (attention/concentration, retrospective memory, prospective memory, and organization/ planning) and was administered at study entry and at the 12-week end point. A variety of demographic, clinical, and treatment-related variables were evaluated as predictors of changes in total and domain scores. Results: All PDQ-K domains showed significant improvement after 12 weeks of antidepressant treatment. More severe initial depressive symptoms, fewer sick-leave days at study entry, and reduced use of concomitant anxiolytics/hypnotics during treatment were significantly associated with greater cognitive improvement. Conclusion: Cognitive symptoms are more responsive to antidepressant treatment in patients with severe MDD. Reduced use of anxiolytics and hypnotics could improve the cognitive functioning of patients with MDD taking antidepressants.

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Section: Discussionmentioning

confidence: 98%

Predictors of Cognitive Improvement during 12 Weeks of Antidepressant Treatment in Patients with Major Depressive Disorder

Lee

Kim

Kang

et al. 2018

Clin Psychopharmacol Neurosci

View full text Add to dashboard Cite

show abstract

“…This was probably due to lack of physical activity, which is consistent with previous studies showing that physical activity positively influences cognitive functioning. 28 , 29) …”

Section: Discussionmentioning

confidence: 99%

Predictors of Cognitive Improvement during 12 Weeks of Antidepressant Treatment in Patients with Major Depressive Disorder

Lee

Kim

Kang

et al. 2018

Clin Psychopharmacol Neurosci

View full text Add to dashboard Cite

ObjectiveCognitive disturbance is one of the major symptoms of depression and may be improved by treatment with antidepressants. This study aimed to investigate the predictors of cognitive improvement in patients with major depressive disorder (MDD) who were taking antidepressants.MethodsThis study included 86 patients with MDD who completed 12 weeks of antidepressant monotherapy. Cognitive symptoms were assessed using the Perceived Deficits Questionnaire-Korean version (PDQ-K), which addresses four domains of cognitive functioning (attention/concentration, retrospective memory, prospective memory, and organization/planning) and was administered at study entry and at the 12-week end point. A variety of demographic, clinical, and treatment-related variables were evaluated as predictors of changes in total and domain scores.ResultsAll PDQ-K domains showed significant improvement after 12 weeks of antidepressant treatment. More severe initial depressive symptoms, fewer sick-leave days at study entry, and reduced use of concomitant anxiolytics/hypnotics during treatment were significantly associated with greater cognitive improvement.ConclusionCognitive symptoms are more responsive to antidepressant treatment in patients with severe MDD. Reduced use of anxiolytics and hypnotics could improve the cognitive functioning of patients with MDD taking antidepressants.

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“…Importantly, a recent meta-analysis of randomized controlled exercise studies indicates that essentially all forms of exercise improve cognitive function in the elderly ( Cai, Li, Hua, Liu, & Chen, 2017 ), though again, initiation and adherence remain major issues ( Vidoni et al, 2017 ). An alternative strategy, therefore, may be to utilize a passive exercise regimen.…”

Section: Introductionmentioning

confidence: 99%

Postural Hypotension and Cognitive Function in Older Adults

McLeod

Jain

2017

Gerontology and Geriatric Medicine

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Background: Cognitive decline in the elderly is associated with chronic cerebral hypoperfusion. While many forms of exercise can slow or reverse cognitive decline, compliance in unsupervised exercise programs is poor. Objective: We address whether passive exercise, that is, muscle stimulation, is capable of reversing postural hypotension in an older adult population sufficiently to significantly improve cognitive function as measured by executive function tests. Subjects and Methods: In this study, 50- to 80-year-old women underwent cognitive testing, long-duration cardiac hemodynamic recordings during quiet sitting, and 60 min of soleus muscle stimulation with continued hemodynamic recording. Results: Two thirds of our subjects were hypotensive (diastolic blood pressure [DBP] < 70 mmHg) after 30 min of quiet sitting. Cognitive performance was significantly better in individuals with higher DBPs (0.79 s per 1-mmHg increase in DBP). Soleus muscle stimulation resulted in an average increase in DBP of 6.1 mmHg, which could translate into a 30% or greater improvement in cognitive performance. Conclusions: Incongruent Stroop testing provides high statistical power for distinguishing differential cognitive responses to resting DBP levels. These results set the stage to investigate whether regular use of calf muscle pump stimulation could effectively reverse age-related cognitive impairment.

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Effect of exercise on cognitive function in chronic disease patients: a meta-analysis and systematic review of randomized controlled trials

Cited by 54 publications

References 62 publications

Predictors of Cognitive Improvement during 12 Weeks of Antidepressant Treatment in Patients with Major Depressive Disorder

Predictors of Cognitive Improvement during 12 Weeks of Antidepressant Treatment in Patients with Major Depressive Disorder

Predictors of Cognitive Improvement during 12 Weeks of Antidepressant Treatment in Patients with Major Depressive Disorder

Postural Hypotension and Cognitive Function in Older Adults

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