Effect of Exercise on Physical Function and Psychological Well-being in Older Patients With Colorectal Cancer Receiving Chemotherapy—A Systematic Review

Lund, Cecilia Margareta; Dolin, Troels G.; Mikkelsen, Marta Kramer; Juhl, Carsten Bogh; Vinther, Anders; Nielsen, Dorte

doi:10.1016/j.clcc.2020.05.012

Cited by 21 publications

(15 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Aerobic and/or resistance exercise led to small but statistically significant improvements in self-reported physical function among patients with a mix of cancer types (SMD 0.22; 95% CI, 0.13 to 0.32; 25 exercise arms) 50 ; breast cancer (SMD 0.14; 95% CI, 0.01 to 0.27; 10 studies, N = 1,016 patients) 32 ; and colorectal cancer (SMD 0.26; 95% CI, 0.04 to 0.48; five studies, N = 330 patients). 39 The results from a meta-analysis of patients with hematologic malignancies were of a similar magnitude but not statistically significant (SMD 0.15; 95% CI, –0.01 to 0.32; eight trials, N = 1,329 patients). 10 Exercise interventions led to mixed results across a range of physical function tests, including 6MWT and Sit to Stand tests, in men with prostate cancer treated with ADT.…”

Section: Recommendationsmentioning

confidence: 92%

“…In patients with breast cancer, metaanalyses suggest that exercise during cancer treatment may reduce both depression (SMD 0.67; 95% CI, 0.51 to 0.83; 10 studies, N 5 730 patients) and anxiety (SMD 0.75; 95% CI, 0.60 to 0.91; 10 studies, N 5 793 patients). 49 Fewer studies have addressed other cancer types, and the results were not significant in meta-analyses of patients with colorectal cancer, 39 hematologic malignancies, 10,17 or lung cancer. 48 Body composition.…”

Section: Recommendationsmentioning

confidence: 99%

“…Hilfiker et al 29 reported a similar or slightly greater magnitude of benefit in analyses across different types of exercise (aerobic: SMD –0.53; 95% CI, –0.80 to –0.26; resistance: SMD –0.53; 95% CI, –1.02 to –0.03; combined resistance and aerobic: SMD –0.67; 95% CI, –1.10 to –0.34), although findings for resistance exercise were no longer significant after excluding studies with fewer than 25 patients per arm (SMD –0.52; 95% CI, –1.21 to 0.17). Meta-analyses that focused on specific types of cancer reported benefits in breast cancer treated with adjuvant chemotherapy and/or radiotherapy, 26 colorectal cancer treated with chemotherapy, 39 lung cancer treated with chemotherapy, 48 prostate cancer treated with radiation therapy, 31 and hematologic malignancies. 10,17…”

Section: Recommendationsmentioning

confidence: 99%

“…Very little evidence was available to evaluate the effects of intentional weight loss or avoidance of weight gain during cancer treatment. 39 lung cancer treated with chemotherapy, 48 prostate cancer treated with radiation therapy, 31 and hematologic malignancies. 10,17 Cardiorespiratory fitness.…”

Section: Study Quality Assessmentmentioning

confidence: 99%

See 3 more Smart Citations

Exercise, Diet, and Weight Management During Cancer Treatment: ASCO Guideline

Ligibel

Bohlke

May

et al. 2022

JCO

282

142

View full text Add to dashboard Cite

PURPOSE To provide guidance on exercise, diet, and weight management during active cancer treatment in adults. METHODS A systematic review of the literature identified systematic reviews and randomized controlled trials evaluating the impact of aerobic and resistance exercise, specific diets and foods, and intentional weight loss and avoidance of weight gain in adults during cancer treatment, on quality of life, treatment toxicity, and cancer control. PubMed and the Cochrane Library were searched from January 2000 to May 2021. ASCO convened an Expert Panel to review the evidence and formulate recommendations. RESULTS The evidence base consisted of 52 systematic reviews (42 for exercise, nine for diet, and one for weight management), and an additional 23 randomized controlled trials. The most commonly studied types of cancer were breast, prostate, lung, and colorectal. Exercise during cancer treatment led to improvements in cardiorespiratory fitness, strength, fatigue, and other patient-reported outcomes. Preoperative exercise in patients with lung cancer led to a reduction in postoperative length of hospital stay and complications. Neutropenic diets did not decrease risk of infection during cancer treatment. RECOMMENDATIONS Oncology providers should recommend regular aerobic and resistance exercise during active treatment with curative intent and may recommend preoperative exercise for patients undergoing surgery for lung cancer. Neutropenic diets are not recommended to prevent infection in patients with cancer during active treatment. Evidence for other dietary and weight loss interventions during cancer treatment was very limited. The guideline discusses special considerations, such as exercise in individuals with advanced cancer, and highlights the critical need for more research in this area, particularly regarding diet and weight loss interventions during cancer treatment. Additional information is available at www.asco.org/supportive-care-guidelines .

show abstract

Section: Recommendationsmentioning

confidence: 92%

Section: Recommendationsmentioning

confidence: 99%

Section: Recommendationsmentioning

confidence: 99%

Section: Study Quality Assessmentmentioning

confidence: 99%

See 2 more Smart Citations

Exercise, Diet, and Weight Management During Cancer Treatment: ASCO Guideline

Ligibel

Bohlke

May

et al. 2022

JCO

282

142

View full text Add to dashboard Cite

show abstract

“…Physical function and frailty have emerged in recent clinical and epidemiological investigations as intervention targets to improve in hematological cancer survivorship [30][31][32]. To date, controlled exercise trials in cancer populations have primarily targeted survivors of solid malignancies such as breast [33][34][35], prostate [36][37][38], colorectal [39][40][41], and lung [42][43][44] cancer. There is a paucity of information on optimal rehabilitation strategies to improve physical function and frailty in patients with multiple myeloma at risk of developing frailty.…”

Section: Discussionmentioning

confidence: 99%

Telehealth exercise to Improve Physical function and frailty in patients with multiple myeloma treated with autologous hematopoietic Stem cell transplantation (TIPS): protocol of a randomized controlled trial

Lee

Nathwani

Shamunee

et al. 2022

Trials

View full text Add to dashboard Cite

Background Advances in autologous hematopoietic stem cell transplantation (HSCT) and supportive care have led to marked improvements in survival for patients with multiple myeloma. Despite these improvements, patients with multiple myeloma remain at high risk of physical dysfunction and frailty due to HSCT and its associated exposures. Although traditional supervised exercise programs can improve frailty in cancer patients and survivors, rehabilitation facilities are typically far from a patient’s residence, are offered on fixed days/hours, contain uniform activities for everyone, and carry a higher risk of contact cross-infection due to immunosuppression, which can be barriers to exercise participation. Innovative personalized interventions are needed to overcome the limitations of traditional exercise interventions. The purpose of this study is to determine the efficacy and sustainability of a telehealth exercise intervention on physical function and frailty in patients with multiple myeloma treated with HSCT. Methods This randomized controlled trial will assess the efficacy of an 8-week telehealth exercise intervention in 60 patients with multiple myeloma who underwent autologous HSCT (30–180 days post-transplant) and are pre-frail or frail. There will be 30 intervention participants and 30 delayed controls. We will administer remote baseline assessments (week 0), followed by an 8-week telehealth intervention (week 1–8), post assessment (week 9), and an additional follow-up assessment (week 17). Our primary endpoint will be improved physical function, as assessed by the Short Physical Performance Battery test. Our secondary endpoint will be a decrease in frailty characteristics such as gait speed, strength, and fatigue. We will also evaluate the sustainability of improved physical function and frailty at week 17. Participants randomized to the intervention group will perform at least 90 min of exercise per week throughout the 8 weeks. Discussion This study will help optimize the delivery of safe, low-cost, and scalable telehealth exercise interventions to improve health outcomes in patients with multiple myeloma, an understudied population at high risk for physical dysfunction and frailty. Our study may provide the foundation for sustainable telehealth exercise interventions to improve physical function and frailty for other hematologic cancer patients (e.g., acute leukemia, lymphoma) as well as any other cancer population of interest. Trial registration ClinicalTrials.govNCT05142371. This study was retrospectively registered on December 2nd, 2021, and is currently open to accrual.

show abstract

Physical function patient‐reported outcomes among adolescent and young adult cancer survivors: A systematic review

Tanner,

Engstrom,

Forbes

et al. 2024

Cancer Medicine

View full text Add to dashboard Cite

BackgroundThe physical challenges faced by adolescents and young adults (AYA) after a cancer diagnosis may be different from those experienced by paediatric and older adult cancer patients. Patient‐reported outcome measures (PROMs) are valuable tools that can be useful in exploring the experiences of AYAs and identifying important issues, recurrent themes and areas to potentially improve quality of life.ObjectiveWe compared patient‐reported physical function outcomes between AYAs diagnosed with cancer and non‐cancer controls.MethodThis paper builds on a scoping review published in early 2023 and focuses on PROMs related to physical function.ResultsThis systematic review includes 16 studies that measured and reported on physical function PROMs in AYA cancer survivors compared with their cancer‐free peers. Of these studies, 14 found that physical function in AYA survivors was significantly worse. This paper also includes a meta‐analysis conducted on 5 studies using the EORTC‐QLQ‐C30 to measure physical function, which found that physical function score was an average of 7.03 (95% CI: −10.21, −3.86) points lower in the AYA cancer group, compared to their cancer free‐peers, a difference that is clinically meaningful.ConclusionsThe results overwhelmingly demonstrate that AYAs post a cancer diagnosis have worse health‐related quality of life from a physical function perspective than their cancer‐free peers, providing a compelling argument for the need to address this issue. All but one of the studies were cross‐sectional, which highlights the need for further assessment of this group longitudinally throughout their cancer journey.

show abstract

Effect of Exercise on Physical Function and Psychological Well-being in Older Patients With Colorectal Cancer Receiving Chemotherapy—A Systematic Review

Cited by 21 publications

References 51 publications

Exercise, Diet, and Weight Management During Cancer Treatment: ASCO Guideline

Exercise, Diet, and Weight Management During Cancer Treatment: ASCO Guideline

Telehealth exercise to Improve Physical function and frailty in patients with multiple myeloma treated with autologous hematopoietic Stem cell transplantation (TIPS): protocol of a randomized controlled trial

Physical function patient‐reported outcomes among adolescent and young adult cancer survivors: A systematic review

Contact Info

Product

Resources

About